Update on Vaccine-Derived Poliovirus Outbreaks - Democratic Republic of the Congo and Horn of Africa, 2017–2018

Update on Vaccine-Derived Poliovirus Outbreaks - Democratic Republic of the Congo and Horn of Africa, 2017–2018

Widespread use of live attenuated (Sabin) oral poliovirus vaccine (OPV) has resulted in marked progress toward global poliomyelitis eradication. However, in underimmunized populations, extensive person-to-person transmission of Sabin poliovirus can result in genetic reversion to neurovirulence and p...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:MMWR. Morbidity and Mortality Weekly Report 2019, Vol.68 (9), p.225-230
Hauptverfasser: Mbaeyi, Chukwuma, Alleman, Mary M, Ehrhardt, Derek, Wiesen, Eric, Burns, Cara C, Liu, Hongmei, Ewetola, Raimi, Seakamela, Lerato, Mdodo, Rennatus, Ndoutabe, Modjirom, Wenye, Pierre Kandolo, Riziki, Yogolelo, Borus, Peter, Kamugisha, Christopher, Wassilak, Steven G F
Format: Report
Sprache:eng
Schlagworte:
Ebola virus
Epidemics
Neurovirulence
Outbreaks
Paralysis
Poliomyelitis
Provinces
Public health
Reversion
Surveillance
Vaccines
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Widespread use of live attenuated (Sabin) oral poliovirus vaccine (OPV) has resulted in marked progress toward global poliomyelitis eradication. However, in underimmunized populations, extensive person-to-person transmission of Sabin poliovirus can result in genetic reversion to neurovirulence and paralytic vaccine-derived poliovirus (VDPV) disease. This report updates (as of Feb 26, 2019) previous reports on circulating VDPV type 2 (cVDPV2) outbreaks during 2017-2018 in the Democratic Republic of the Congo (DRC) and in Somalia, which experienced a concurrent cVDPV type 3 (cVDPV3) outbreak. In DRC, 42 cases have been reported in four cVDPV2 outbreaks; paralysis onset in the most recent case was Oct 7, 2018.
ISSN:0149-2195
1545-861X