Neonatal lupus erythematosus
Neonatal lupus erythematosus (NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, in particular anti-Ro(SS-A), anti-La(SS-B), or both. The majority of infants with NLE exhibit isolated congenital heart block, cutaneous lesions analogous...
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| Veröffentlicht in: | Cutis (New York, N.Y.) N.Y.), 2000-06, Vol.65 (6), p.379-381 |
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| container_title | Cutis (New York, N.Y.) |
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| creator | CORONA, R ANGELO, C CACCIAGUERRA, M. G CONTI, G DE PITA, O COLETTI, V EL HACHEM, M PARADISI, M |
| description | Neonatal lupus erythematosus (NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, in particular anti-Ro(SS-A), anti-La(SS-B), or both. The majority of infants with NLE exhibit isolated congenital heart block, cutaneous lesions analogous to those of adult subacute cutaneous lupus erythematosus, or both. We report a case of NLE in a 3-month-old male infant, born to a clinically asymptomatic mother, presenting small, annular, erythematous plaques with sharp, hyperkeratotic borders and central clearing localized at the eyebrow region. Both the infant and the mother were positive for anti-Ro(SS-A). |
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G ; CONTI, G ; DE PITA, O ; COLETTI, V ; EL HACHEM, M ; PARADISI, M</creator><creatorcontrib>CORONA, R ; ANGELO, C ; CACCIAGUERRA, M. G ; CONTI, G ; DE PITA, O ; COLETTI, V ; EL HACHEM, M ; PARADISI, M</creatorcontrib><description>Neonatal lupus erythematosus (NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, in particular anti-Ro(SS-A), anti-La(SS-B), or both. The majority of infants with NLE exhibit isolated congenital heart block, cutaneous lesions analogous to those of adult subacute cutaneous lupus erythematosus, or both. We report a case of NLE in a 3-month-old male infant, born to a clinically asymptomatic mother, presenting small, annular, erythematous plaques with sharp, hyperkeratotic borders and central clearing localized at the eyebrow region. Both the infant and the mother were positive for anti-Ro(SS-A).</description><identifier>ISSN: 0011-4162</identifier><identifier>EISSN: 2326-6929</identifier><identifier>PMID: 10879307</identifier><identifier>CODEN: CUTIBC</identifier><language>eng</language><publisher>Chatham, NJ: Quadrant HealthCom</publisher><subject>Adult ; Autoantibodies - blood ; Biological and medical sciences ; Diagnosis, Differential ; Facial Dermatoses - diagnosis ; Facial Dermatoses - pathology ; Female ; Humans ; Infant ; Infectious Disease Transmission, Vertical ; Lupus Erythematosus, Cutaneous - diagnosis ; Lupus Erythematosus, Cutaneous - genetics ; Lupus Erythematosus, Cutaneous - pathology ; Male ; Medical sciences ; Pregnancy ; Pregnancy Complications - diagnosis ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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Both the infant and the mother were positive for anti-Ro(SS-A).</description><subject>Adult</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Diagnosis, Differential</subject><subject>Facial Dermatoses - diagnosis</subject><subject>Facial Dermatoses - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Lupus Erythematosus, Cutaneous - diagnosis</subject><subject>Lupus Erythematosus, Cutaneous - genetics</subject><subject>Lupus Erythematosus, Cutaneous - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - diagnosis</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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G</au><au>CONTI, G</au><au>DE PITA, O</au><au>COLETTI, V</au><au>EL HACHEM, M</au><au>PARADISI, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal lupus erythematosus</atitle><jtitle>Cutis (New York, N.Y.)</jtitle><addtitle>Cutis</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>65</volume><issue>6</issue><spage>379</spage><epage>381</epage><pages>379-381</pages><issn>0011-4162</issn><eissn>2326-6929</eissn><coden>CUTIBC</coden><abstract>Neonatal lupus erythematosus (NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, in particular anti-Ro(SS-A), anti-La(SS-B), or both. The majority of infants with NLE exhibit isolated congenital heart block, cutaneous lesions analogous to those of adult subacute cutaneous lupus erythematosus, or both. We report a case of NLE in a 3-month-old male infant, born to a clinically asymptomatic mother, presenting small, annular, erythematous plaques with sharp, hyperkeratotic borders and central clearing localized at the eyebrow region. Both the infant and the mother were positive for anti-Ro(SS-A).</abstract><cop>Chatham, NJ</cop><pub>Quadrant HealthCom</pub><pmid>10879307</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Cutis (New York, N.Y.), 2000-06, Vol.65 (6), p.379-381 |
| issn | 0011-4162 2326-6929 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Autoantibodies - blood Biological and medical sciences Diagnosis, Differential Facial Dermatoses - diagnosis Facial Dermatoses - pathology Female Humans Infant Infectious Disease Transmission, Vertical Lupus Erythematosus, Cutaneous - diagnosis Lupus Erythematosus, Cutaneous - genetics Lupus Erythematosus, Cutaneous - pathology Male Medical sciences Pregnancy Pregnancy Complications - diagnosis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis |
| title | Neonatal lupus erythematosus |
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