Optimization techniques for the design and development of novel drug delivery systems, Part II
Optimization techniques are being explored extensively in pharmaceutical research as a tool to achieve the optimum composition of a delivery system. The design and development of novel drug delivery systems involve careful selection and optimization of several formulation- and process-related variab...
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| Veröffentlicht in: | Pharmaceutical Technology 2003-03, Vol.27 (3), p.102 |
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| creator | Kannan, Vinayagam Kandarapu, Raghupathi Garg, Sanjay |
| description | Optimization techniques are being explored extensively in pharmaceutical research as a tool to achieve the optimum composition of a delivery system. The design and development of novel drug delivery systems involve careful selection and optimization of several formulation- and process-related variables. Drug delivery from modified-release systems is usually affected by inherent gastrointestinal tract variables such as pH, gastric motility, and contents. Floating drug delivery systems have been pursued extensively as a promising approach to increase the gastric residence time of peroral controlled-release systems. These systems consist of buoyant polymers that are retained in the stomach for an extended period of time to provide continuous release of an incorporated drug. Designing a peroral drug delivery system that is capable of delivering drugs in a pulsatile or timed-release fashion requires delivery methods such as multilayered tablets and coated pellets. Colonic drug delivery is gaining interest as one of the important targeted drug delivery systems. |
| format | Magazinearticle |
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The design and development of novel drug delivery systems involve careful selection and optimization of several formulation- and process-related variables. Drug delivery from modified-release systems is usually affected by inherent gastrointestinal tract variables such as pH, gastric motility, and contents. Floating drug delivery systems have been pursued extensively as a promising approach to increase the gastric residence time of peroral controlled-release systems. These systems consist of buoyant polymers that are retained in the stomach for an extended period of time to provide continuous release of an incorporated drug. Designing a peroral drug delivery system that is capable of delivering drugs in a pulsatile or timed-release fashion requires delivery methods such as multilayered tablets and coated pellets. 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| source | Business Source Complete |
| subjects | Colon Drug delivery devices Drug delivery systems Drug dosages Investigations Motility Optimization Optimization techniques Pharmaceuticals Polymers Process planning R&D Research & development Stomach Systems design Variables |
| title | Optimization techniques for the design and development of novel drug delivery systems, Part II |
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