Effects of column inner diameter and packed bed heterogeneities on chromatographic performance

Reduced flow rates are also advantageous when attempting to improve the limits of detection (LOD) of methods that couple high performance liquid chromatography (HPLC) to electrospray ionization mass spectrometry (ESI-MS) (5). In capillaries, the correlation of column packing parameters and chromatog...

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Veröffentlicht in:LC GC North America 2016-06, Vol.34 (6), p.388
Hauptverfasser: Franklin, Edward G, Kahler, Ty.W, Bell, David S
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description Reduced flow rates are also advantageous when attempting to improve the limits of detection (LOD) of methods that couple high performance liquid chromatography (HPLC) to electrospray ionization mass spectrometry (ESI-MS) (5). In capillaries, the correlation of column packing parameters and chromatographic performance to the morphological structures of packed beds suggests possible means to improve the intrinsic efficiencies of columns by improving radial homogeneity and reducing transcolumn eddy dispersion (6).
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source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Business Source Complete; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry
subjects Atoms & subatomic particles
Chromatography
Efficiency
Flow velocity
Morphology
Particle size
Velocity
title Effects of column inner diameter and packed bed heterogeneities on chromatographic performance
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