Fat Content in Liver and Skeletal Muscle Changes in a Reciprocal Manner in Patients with Acromegaly during Combination Therapy with a Somatostatin Analog and a GH Receptor Antagonist: A Randomized Clinical Trial

Context: Pegvisomant is a GH antagonist, which is used for the treatment of acromegalic patients. It effectively blocks the hepatic and peripheral effects of GH, but transient elevations in circulating liver enzymes of unknown pathogenesis may occur, which seems to be more prevalent when the treatme...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2012-04, Vol.97 (4), p.1227-1235
Hauptverfasser:	Madsen, Michael, Krusenstjerna-Hafstrøm, Thomas, Møller, Louise, Christensen, Britt, Vendelbo, Mikkel Holm, Pedersen, Steen B, Frystyk, Jan, Jessen, Niels, Hansen, Troels Krarup, Stødkilde-Jørgensen, Hans, Flyvbjerg, Allan, Jørgensen, Jens Otto L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly - drug therapy Acromegaly - metabolism Acromegaly - pathology Acromegaly - physiopathology Biological and medical sciences Biopsy, Needle Dose-Response Relationship, Drug Drug Therapy, Combination - adverse effects Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Hepatic Insufficiency - chemically induced Human Growth Hormone - administration & dosage Human Growth Hormone - adverse effects Human Growth Hormone - analogs & derivatives Human Growth Hormone - therapeutic use Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Lipectomy Lipid Metabolism - drug effects Liver - drug effects Liver - metabolism Liver - physiopathology Magnetic Resonance Spectroscopy Male Medical sciences Middle Aged Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Non tumoral diseases. Target tissue resistance. Benign neoplasms Receptors, Somatotropin - antagonists & inhibitors Somatostatin - administration & dosage Somatostatin - adverse effects Somatostatin - analogs & derivatives Somatostatin - therapeutic use Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology
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