L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice

The activity of IDO that catalyzes the degradation of tryptophan (Trp) into kynurenine (Kyn) increases after diseases caused by different infectious agents. Previously, we demonstrated that IDO has an important immunomodulatory function in immune-related diseases. However, the pathophysiological rol...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-04, Vol.188 (8), p.3980-3987
Hauptverfasser:	Hoshi, Masato, Matsumoto, Keishi, Ito, Hiroyasu, Ohtaki, Hirofumi, Arioka, Yuko, Osawa, Yosuke, Yamamoto, Yasuko, Matsunami, Hidetoshi, Hara, Akira, Seishima, Mitsuru, Saito, Kuniaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Cardiovirus Infections - immunology Cardiovirus Infections - mortality Cardiovirus Infections - virology Encephalomyocarditis virus Indoleamine-Pyrrole 2,3,-Dioxygenase - deficiency Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology Interferon Type I - biosynthesis Interferon Type I - immunology Kynurenine - blood Kynurenine - immunology Male Mice Mice, Knockout Myocarditis - immunology Myocarditis - mortality Myocarditis - virology Myocardium - immunology Myocardium - metabolism Signal Transduction - immunology Spleen - immunology Spleen - metabolism Spleen - virology Survival Rate Tryptophan - analogs & derivatives Tryptophan - blood Tryptophan - immunology Tryptophan - pharmacology Viral Load - drug effects Virus Replication
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