[18F]FLT-PET Imaging Does Not Always Light Up Proliferating Tumor Cells

[(18)F]FLT (3'-Fluoro-3' deoxythymidine)-PET imaging was proposed as a tool for measuring in vivo tumor cell proliferation. The aim of this article was to validate the use of [(18)F]FLT-PET imaging for measuring xenograft proliferation and subsequent monitoring of targeted therapy. In expo...

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Veröffentlicht in:	Clinical cancer research 2012-03, Vol.18 (5), p.1303-1312
Hauptverfasser:	ZHANG, Cathy C, ZHENGMING YAN, FAHEY, Neeta R, CULLINANE, Carleen, SPILKER, Mary, ZASADNY, Kenneth, O'BRIEN, Peter, BUCKMAN, Dana, WONG, Anthony, CHRISTENSEN, James G, WENLIN LI, KUSZPIT, Kyle, PAINTER, Cory L, QIN ZHANG, LAPPIN, Patrick B, NICHOLS, Tim, LIRA, Maruja E, AFFOLTER, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Biological and medical sciences Bromodeoxyuridine - metabolism Cell Cycle Checkpoints - drug effects Cell Proliferation - drug effects Cyclin-Dependent Kinases - antagonists & inhibitors Dideoxynucleosides - pharmacokinetics Disease Models, Animal Humans Medical sciences Mice Mice, Nude Mice, SCID Neoplasms - diagnostic imaging Neoplasms - drug therapy Neoplasms - metabolism Pharmacology. Drug treatments Piperazines - administration & dosage Piperazines - pharmacology Positron-Emission Tomography Pyridines - administration & dosage Pyridines - pharmacology Thymidine - metabolism Xenograft Model Antitumor Assays
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