Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration

J. Neurochem. (2012) 121, 217–227. The extension of microglial processes toward injured sites in the brain is triggered by the stimulation of the purinergic receptor P2Y12 by extracellular ATP. We recently showed that P2Y12 stimulation by ATP induces microglial process extension in collagen gels. In...

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Veröffentlicht in:	Journal of neurochemistry 2012-04, Vol.121 (2), p.217-227
Hauptverfasser:	Ohsawa, Keiko, Sanagi, Tomomi, Nakamura, Yasuko, Suzuki, Eri, Inoue, Kazuhide, Kohsaka, Shinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - pharmacology Adenosine A3 Receptor Agonists - pharmacology Adenosine A3 receptors Adenosine deaminase Adenosine Deaminase Inhibitors - pharmacology Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - pharmacology Adult and adolescent clinical studies Animals Animals, Newborn ATP Biological and medical sciences Brain Cell adhesion & migration Cell migration Cell Movement - drug effects Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects chemotaxis Chemotaxis - drug effects Collagen Enzymes Flow Cytometry Gels Indicators and Reagents Injuries of the nervous system and the skull. Diseases due to physical agents JNK Mitogen-Activated Protein Kinases - physiology Medical sciences Microglia Microglia - drug effects motility Neurochemistry Neurons Organic mental disorders. Neuropsychology P2Y12 Polymerase chain reaction Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Purine receptors purinergic Purinergic P2Y Receptor Agonists - pharmacology Rats Rats, Wistar Real-Time Polymerase Chain Reaction Receptor, Adenosine A1 - biosynthesis Receptor, Adenosine A3 - drug effects Receptor, Adenosine A3 - physiology Receptors, Purinergic P2Y12 - drug effects Thionucleotides - pharmacology Traumas. Diseases due to physical agents
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