Efficacy of homologous inositol hexaphosphate-loaded red blood cells in sickle transgenic mice

Summary Patients with sickle cell disease (SCD) can present several severe symptoms during their lifetime, including painful events due to vascular occlusion (VOC). Even though multiple factors are involved in VOC, hypoxia is the most important triggering factor. Inositol hexaphosphate (IHP) reduces...

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Veröffentlicht in:	British journal of haematology 2012-05, Vol.157 (3), p.357-369
Hauptverfasser:	Bourgeaux, Vanessa, Aufradet, Emeline, Campion, Yannick, De Souza, Geneviève, Horand, Françoise, Bessaad, Amine, Chevrier, Anne-Marie, Canet-Soulas, Emmanuelle, Godfrin, Yann, Martin, Cyril
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Sickle Cell - complications Anemia, Sickle Cell - physiopathology Anemia, Sickle Cell - therapy Anemias. Hemoglobinopathies Animals Arterial Occlusive Diseases - etiology Arterial Occlusive Diseases - prevention & control Biological and medical sciences blood transfusion Brain - growth & development Brain - pathology cellular therapies Disease Models, Animal Diseases of red blood cells Erythrocyte Transfusion - adverse effects Erythrocyte Transfusion - methods erythrocytes Female Hematologic and hematopoietic diseases Hypoxia - etiology Hypoxia - prevention & control Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Organ Size oxygen affinity Phytic Acid - therapeutic use Risk Factors sickle cell disease Spleen - growth & development Spleen - pathology Survival Analysis transgenic mice model Treatment Outcome
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