Excellent outcome of matched unrelated donor transplantation in paediatric aplastic anaemia following failure with immunosuppressive therapy: a United Kingdom multicentre retrospective experience

Summary We retrospectively analysed the outcome of consecutive children with idiopathic severe aplastic anaemia in the United Kingdom who received immunosuppressive therapy (IST) or matched unrelated donor (MUD) haematopoietic stem cell transplantation (HSCT). The 6‐month cumulative response rate fo...

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Veröffentlicht in:	British journal of haematology 2012-05, Vol.157 (3), p.339-346
Hauptverfasser:	Samarasinghe, Sujith, Steward, Colin, Hiwarkar, Prashant, Saif, Muhammad Ameer, Hough, Rachael, Webb, David, Norton, Alice, Lawson, Sarah, Qureshi, Amrana, Connor, Philip, Carey, Peter, Skinner, Rod, Vora, Ajay, Pelidis, Maria, Gibson, Brenda, Stewart, Graham, Keogh, Steve, Goulden, Nick, Bonney, Denise, Stubbs, Mathew, Amrolia, Persis, Rao, Kanchan, Meyer, Stefan, Wynn, Rob, Veys, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anemia Anemia, Aplastic - therapy Antilymphocyte serum Antilymphocyte Serum - therapeutic use Aplastic Anaemia Biological and medical sciences Child Child, Preschool Children Chimerism Cyclophosphamide Cyclosporine - therapeutic use Data processing Donors Female fludarabine Graft vs Host Disease - etiology Grafts Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - methods Histocompatibility antigen HLA Humans Immunosuppressive agents Immunosuppressive Agents - therapeutic use immunosuppressive therapy Infant Kaplan-Meier Estimate Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Monoclonal antibodies Opportunistic Infections - etiology Other diseases. Hematologic involvement in other diseases paediatric aplastic anaemia Pediatrics Rabbit ATG Radiation Radiotherapy Recurrence Rejection Retrospective Studies stem cell transplantation Transplantation Transplantation Chimera Transplantation Conditioning - methods Treatment Failure Treatment Outcome Unrelated Donors
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