Structure of 2-Methylisoborneol Synthase from Streptomyces coelicolor and Implications for the Cyclization of a Noncanonical C-Methylated Monoterpenoid Substrate

The crystal structure of 2-methylisoborneol synthase (MIBS) from Streptomyces coelicolor A3(2) has been determined in complex with substrate analogues geranyl-S-thiolodiphosphate and 2-fluorogeranyl diphosphate at 1.80 and 1.95 Å resolution, respectively. This terpenoid cyclase catalyzes the cycliza...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 2012-04, Vol.51 (14), p.3011-3020
Hauptverfasser:	Köksal, Mustafa, Chou, Wayne K. W, Cane, David E, Christianson, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	2-methylisoborneol alcohols Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding Sites Bornanes - chemistry Bornanes - metabolism crystal structure Crystallography, X-Ray Cyclization Models, Molecular Monoterpenes - chemistry Monoterpenes - metabolism odors Protein Conformation stereochemistry Streptomyces coelicolor Streptomyces coelicolor - enzymology Streptomyces coelicolor - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!