Serum Total p -Cresol and Indoxyl Sulfate Correlated With Stage of Chronic Kidney Disease in Renal Transplant Recipients
Abstract Background Uremic toxins are considered cardiovascular and mortality risk factors in chronic kidney disease (CKD) patients. Both p -cresol and indoxyl sulfate have been shown to induce oxidative stress in vitro and subsequent endothelial dysfunction in uremic patients. Our study evaluated t...
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| Veröffentlicht in: | Transplantation proceedings 2012-04, Vol.44 (3), p.621-624 |
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| description | Abstract Background Uremic toxins are considered cardiovascular and mortality risk factors in chronic kidney disease (CKD) patients. Both p -cresol and indoxyl sulfate have been shown to induce oxidative stress in vitro and subsequent endothelial dysfunction in uremic patients. Our study evaluated the levels of p -cresol and indoxyl sulfate, and whether they contribute to the progression of CKD in transplant recipients. Methods We retrospectively evaluated 95 patients who had received a transplant from February 1987 to June 2010 in our center; the recipients had a mean transplant duration of 5.3 ± 4.9 years and a mean age of 47.8 ± 14.1 years. Among them, 56.8% (54/95) were male. Patients with glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m2 were selected for group 1 (n = 35), and those with GFR < 60 mL/min/1.73 m2 were selected for group 2 (n = 60). Demographic and clinical data were compared between groups. Serum and urine levels of p -cresol and indoxyl sulfate were also obtained. Results Baseline serum p -cresol and indoxyl sulfate levels were significantly higher in advanced CKD stages ( P = .001 and |
| doi_str_mv | 10.1016/j.transproceed.2011.11.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_993103725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0041134511016204</els_id><sourcerecordid>993103725</sourcerecordid><originalsourceid>FETCH-LOGICAL-c464t-a0dabffa360a4d499a2534f85fe719d696f8f1b63ba27e7270699d686ae611ad3</originalsourceid><addsrcrecordid>eNqNkl2LEzEUhoMobq3-BQmCeDU1X810vBBk1o_FBcFWvAxpcuKmppOaZGT7783YLopXwoEkJ-95c3hOEHpGyYISKl_uFiXpIR9SNAB2wQilixqE8XtoRlctb5hk_D6aESJoQ7lYXqBHOe9IPTPBH6ILxsSqpvkM3a4hjXu8iUUHfMBNnyDHgPVg8dVg4-0x4PUYnC6A-5gShLqz-KsvN3hd9DfA0eH-JsXBG_zR2wGO-NJn0BmwH_BnGKrt5ne3QQ-lJow_eBhKfoweOB0yPDmvc_Tl3dtN_6G5_vT-qn9z3RghRWk0sXrrnOaSaGFF12m25MKtlg5a2lnZSbdydCv5VrMWWtYS2dX0SmqQlGrL5-jFybfi-jFCLmrvs4FQ24E4ZtV1nBLeVtc5enVSmhRzTuDUIfm9TkdFiZrAq536G7yawKsaFXwtfnp-Ztzu691d6R3pKnh-FuhsdHDVyPj8RydJy9vl1MXlSQcVyk8PSWVTgRmwPoEpykb_f_28_sfGBF-HpMN3OELexTHV0WRFVWaKqPX0VaafQidjRgT_BVpJvbs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>993103725</pqid></control><display><type>article</type><title>Serum Total p -Cresol and Indoxyl Sulfate Correlated With Stage of Chronic Kidney Disease in Renal Transplant Recipients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Collection</source><creator>Huang, S.-T ; Shu, K.-H ; Cheng, C.-H ; Wu, M.-J ; Yu, T.-M ; Chuang, Y.-W ; Chen, C.-H</creator><creatorcontrib>Huang, S.-T ; Shu, K.-H ; Cheng, C.-H ; Wu, M.-J ; Yu, T.-M ; Chuang, Y.-W ; Chen, C.-H</creatorcontrib><description>Abstract Background Uremic toxins are considered cardiovascular and mortality risk factors in chronic kidney disease (CKD) patients. Both p -cresol and indoxyl sulfate have been shown to induce oxidative stress in vitro and subsequent endothelial dysfunction in uremic patients. Our study evaluated the levels of p -cresol and indoxyl sulfate, and whether they contribute to the progression of CKD in transplant recipients. Methods We retrospectively evaluated 95 patients who had received a transplant from February 1987 to June 2010 in our center; the recipients had a mean transplant duration of 5.3 ± 4.9 years and a mean age of 47.8 ± 14.1 years. Among them, 56.8% (54/95) were male. Patients with glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m2 were selected for group 1 (n = 35), and those with GFR < 60 mL/min/1.73 m2 were selected for group 2 (n = 60). Demographic and clinical data were compared between groups. Serum and urine levels of p -cresol and indoxyl sulfate were also obtained. Results Baseline serum p -cresol and indoxyl sulfate levels were significantly higher in advanced CKD stages ( P = .001 and <.0001, respectively). Patients at advanced CKD stages (group 2) had lower serum levels of hemoglobin and albumin ( P < .0001), but higher levels of total cholesterol, triglyceride, and uric acid levels ( P = .04, .04 and .001, respectively). Body mass index, C-reactive protein, and serum calcium and phosphate levels showed no significant differences between groups. The cut-off value for serum p -cresol between groups was 1.28 umol/L ( P = .01), and that for the indoxyl sulfate level was 0.98 umol/L ( P = .0001). Conclusion The serum p -cresol and indoxyl sulfate levels were significantly higher in advanced CKD stages in transplant recipients. To evaluate the use of serum p -cresol and indoxyl sulfate levels as a predictive tool for survival, larger clinical studies are needed.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2011.11.023</identifier><identifier>PMID: 22483453</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Cresols - blood ; Disease Progression ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Indican - blood ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - pathology ; Kidney Failure, Chronic - surgery ; Kidney Transplantation ; Kidneys ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>Transplantation proceedings, 2012-04, Vol.44 (3), p.621-624</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-a0dabffa360a4d499a2534f85fe719d696f8f1b63ba27e7270699d686ae611ad3</citedby><cites>FETCH-LOGICAL-c464t-a0dabffa360a4d499a2534f85fe719d696f8f1b63ba27e7270699d686ae611ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134511016204$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26073755$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22483453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, S.-T</creatorcontrib><creatorcontrib>Shu, K.-H</creatorcontrib><creatorcontrib>Cheng, C.-H</creatorcontrib><creatorcontrib>Wu, M.-J</creatorcontrib><creatorcontrib>Yu, T.-M</creatorcontrib><creatorcontrib>Chuang, Y.-W</creatorcontrib><creatorcontrib>Chen, C.-H</creatorcontrib><title>Serum Total p -Cresol and Indoxyl Sulfate Correlated With Stage of Chronic Kidney Disease in Renal Transplant Recipients</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Background Uremic toxins are considered cardiovascular and mortality risk factors in chronic kidney disease (CKD) patients. Both p -cresol and indoxyl sulfate have been shown to induce oxidative stress in vitro and subsequent endothelial dysfunction in uremic patients. Our study evaluated the levels of p -cresol and indoxyl sulfate, and whether they contribute to the progression of CKD in transplant recipients. Methods We retrospectively evaluated 95 patients who had received a transplant from February 1987 to June 2010 in our center; the recipients had a mean transplant duration of 5.3 ± 4.9 years and a mean age of 47.8 ± 14.1 years. Among them, 56.8% (54/95) were male. Patients with glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m2 were selected for group 1 (n = 35), and those with GFR < 60 mL/min/1.73 m2 were selected for group 2 (n = 60). Demographic and clinical data were compared between groups. Serum and urine levels of p -cresol and indoxyl sulfate were also obtained. Results Baseline serum p -cresol and indoxyl sulfate levels were significantly higher in advanced CKD stages ( P = .001 and <.0001, respectively). Patients at advanced CKD stages (group 2) had lower serum levels of hemoglobin and albumin ( P < .0001), but higher levels of total cholesterol, triglyceride, and uric acid levels ( P = .04, .04 and .001, respectively). Body mass index, C-reactive protein, and serum calcium and phosphate levels showed no significant differences between groups. The cut-off value for serum p -cresol between groups was 1.28 umol/L ( P = .01), and that for the indoxyl sulfate level was 0.98 umol/L ( P = .0001). Conclusion The serum p -cresol and indoxyl sulfate levels were significantly higher in advanced CKD stages in transplant recipients. To evaluate the use of serum p -cresol and indoxyl sulfate levels as a predictive tool for survival, larger clinical studies are needed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cresols - blood</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Indican - blood</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - pathology</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Transplantation</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl2LEzEUhoMobq3-BQmCeDU1X810vBBk1o_FBcFWvAxpcuKmppOaZGT7783YLopXwoEkJ-95c3hOEHpGyYISKl_uFiXpIR9SNAB2wQilixqE8XtoRlctb5hk_D6aESJoQ7lYXqBHOe9IPTPBH6ILxsSqpvkM3a4hjXu8iUUHfMBNnyDHgPVg8dVg4-0x4PUYnC6A-5gShLqz-KsvN3hd9DfA0eH-JsXBG_zR2wGO-NJn0BmwH_BnGKrt5ne3QQ-lJow_eBhKfoweOB0yPDmvc_Tl3dtN_6G5_vT-qn9z3RghRWk0sXrrnOaSaGFF12m25MKtlg5a2lnZSbdydCv5VrMWWtYS2dX0SmqQlGrL5-jFybfi-jFCLmrvs4FQ24E4ZtV1nBLeVtc5enVSmhRzTuDUIfm9TkdFiZrAq536G7yawKsaFXwtfnp-Ztzu691d6R3pKnh-FuhsdHDVyPj8RydJy9vl1MXlSQcVyk8PSWVTgRmwPoEpykb_f_28_sfGBF-HpMN3OELexTHV0WRFVWaKqPX0VaafQidjRgT_BVpJvbs</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Huang, S.-T</creator><creator>Shu, K.-H</creator><creator>Cheng, C.-H</creator><creator>Wu, M.-J</creator><creator>Yu, T.-M</creator><creator>Chuang, Y.-W</creator><creator>Chen, C.-H</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>Serum Total p -Cresol and Indoxyl Sulfate Correlated With Stage of Chronic Kidney Disease in Renal Transplant Recipients</title><author>Huang, S.-T ; Shu, K.-H ; Cheng, C.-H ; Wu, M.-J ; Yu, T.-M ; Chuang, Y.-W ; Chen, C.-H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-a0dabffa360a4d499a2534f85fe719d696f8f1b63ba27e7270699d686ae611ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cresols - blood</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Indican - blood</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - pathology</topic><topic>Kidney Failure, Chronic - surgery</topic><topic>Kidney Transplantation</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, S.-T</creatorcontrib><creatorcontrib>Shu, K.-H</creatorcontrib><creatorcontrib>Cheng, C.-H</creatorcontrib><creatorcontrib>Wu, M.-J</creatorcontrib><creatorcontrib>Yu, T.-M</creatorcontrib><creatorcontrib>Chuang, Y.-W</creatorcontrib><creatorcontrib>Chen, C.-H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, S.-T</au><au>Shu, K.-H</au><au>Cheng, C.-H</au><au>Wu, M.-J</au><au>Yu, T.-M</au><au>Chuang, Y.-W</au><au>Chen, C.-H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Total p -Cresol and Indoxyl Sulfate Correlated With Stage of Chronic Kidney Disease in Renal Transplant Recipients</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>44</volume><issue>3</issue><spage>621</spage><epage>624</epage><pages>621-624</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Background Uremic toxins are considered cardiovascular and mortality risk factors in chronic kidney disease (CKD) patients. Both p -cresol and indoxyl sulfate have been shown to induce oxidative stress in vitro and subsequent endothelial dysfunction in uremic patients. Our study evaluated the levels of p -cresol and indoxyl sulfate, and whether they contribute to the progression of CKD in transplant recipients. Methods We retrospectively evaluated 95 patients who had received a transplant from February 1987 to June 2010 in our center; the recipients had a mean transplant duration of 5.3 ± 4.9 years and a mean age of 47.8 ± 14.1 years. Among them, 56.8% (54/95) were male. Patients with glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m2 were selected for group 1 (n = 35), and those with GFR < 60 mL/min/1.73 m2 were selected for group 2 (n = 60). Demographic and clinical data were compared between groups. Serum and urine levels of p -cresol and indoxyl sulfate were also obtained. Results Baseline serum p -cresol and indoxyl sulfate levels were significantly higher in advanced CKD stages ( P = .001 and <.0001, respectively). Patients at advanced CKD stages (group 2) had lower serum levels of hemoglobin and albumin ( P < .0001), but higher levels of total cholesterol, triglyceride, and uric acid levels ( P = .04, .04 and .001, respectively). Body mass index, C-reactive protein, and serum calcium and phosphate levels showed no significant differences between groups. The cut-off value for serum p -cresol between groups was 1.28 umol/L ( P = .01), and that for the indoxyl sulfate level was 0.98 umol/L ( P = .0001). Conclusion The serum p -cresol and indoxyl sulfate levels were significantly higher in advanced CKD stages in transplant recipients. To evaluate the use of serum p -cresol and indoxyl sulfate levels as a predictive tool for survival, larger clinical studies are needed.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22483453</pmid><doi>10.1016/j.transproceed.2011.11.023</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Cresols - blood Disease Progression Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Indican - blood Kidney Failure, Chronic - blood Kidney Failure, Chronic - pathology Kidney Failure, Chronic - surgery Kidney Transplantation Kidneys Male Medical sciences Nephrology. Urinary tract diseases Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Urinary system involvement in other diseases. Miscellaneous |
| title | Serum Total p -Cresol and Indoxyl Sulfate Correlated With Stage of Chronic Kidney Disease in Renal Transplant Recipients |
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