Structural Insight into the Bacterial Mucinase StcE Essential to Adhesion and Immune Evasion during Enterohemorrhagic E. coli Infection

Mucin glycoproteins with large numbers of O-linked glycosylations comprise the mucosal barrier lining the mammalian gastrointestinal tract from mouth to gut. A critical biological function of mucins is to protect the underlying epithelium from infection. Enterohemorrhagic Escherichia coli (EHEC), th...

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Veröffentlicht in:	Structure (London) 2012-04, Vol.20 (4), p.707-717
Hauptverfasser:	Yu, Angel C.Y., Worrall, Liam J., Strynadka, Natalie C.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Adhesion - genetics Bacterial Adhesion - immunology Carbohydrate Conformation Catalytic Domain Crystallography, X-Ray Enterohemorrhagic Escherichia coli - chemistry Enterohemorrhagic Escherichia coli - immunology Enterohemorrhagic Escherichia coli - metabolism Escherichia coli Escherichia coli Infections - immunology Escherichia coli Infections - microbiology Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Humans Immune Evasion Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Metalloendopeptidases - chemistry Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Models, Molecular Mucins - chemistry Mucins - metabolism Protein Binding Protein Structure, Secondary Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Static Electricity Stereoisomerism Substrate Specificity
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