Dynamics of transcription of closely spaced promoters in Escherichia coli, one event at a time

Many pairs of genes in Escherichia coli are driven by closely spaced promoters. We study the dynamics of expression of such pairs of genes driven by a model at the molecule and nucleotide level with delayed stochastic dynamics as a function of the binding affinity of the RNA polymerase to the promot...

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Veröffentlicht in:	Journal of theoretical biology 2012-05, Vol.301, p.83-94
Hauptverfasser:	Martins, Leonardo, Mäkelä, Jarno, Häkkinen, Antti, Kandhavelu, Meenakshisundaram, Yli-Harja, Olli, Fonseca, José M., Ribeiro, Andre S.
Format:	Artikel
Sprache:	eng
Schlagworte:	bacteria behavior change binding capacity Closely spaced promoters DNA-directed RNA polymerase DNA-Directed RNA Polymerases - metabolism Escherichia coli Escherichia coli - genetics Gene Expression Regulation, Bacterial - genetics genes Genes, Bacterial genetic engineering Models, Genetic Open complex formation promoter regions Promoter Regions, Genetic - genetics RNA RNA, Bacterial - biosynthesis Stochastic dynamics Stochastic Processes Transcription Initiation Site Transcription start sites Transcription, Genetic
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