Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1–Ddr2–Mmp-13 degradative pathway: a new model of osteoarthritis

Summary Objective To test the hypothesis that the spondyloepiphyseal dysplasia congenita ( sedc ) heterozygous ( sedc /+) mouse, a COL2A1 mutant, is a model for the study of osteoarthritis (OA) in the absence of dwarfism and to investigate the presence of HtrA1, Ddr2, and Mmp-13 and their possible i...

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Veröffentlicht in:	Osteoarthritis and cartilage 2012-05, Vol.20 (5), p.430-439
Hauptverfasser:	Holt, D.W, Henderson, M.L, Stockdale, C.E, Farrell, J.T, Kooyman, D.L, Bridgewater, L.C, Seegmiller, R.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - genetics Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Cartilage degradation Cartilage, Articular - metabolism Collagen Type II - genetics Collagen Type VI - metabolism Ddr2 Discoidin Domain Receptors Disease Progression Femur - pathology Genetic Predisposition to Disease High-Temperature Requirement A Serine Peptidase 1 HtrA1 Male Matrix Metalloproteinase 13 - metabolism Mice Mice, Mutant Strains Mmp-13 Mutation Osteoarthritis Osteoarthritis - genetics Osteoarthritis - metabolism Osteoarthritis - pathology Osteochondrodysplasias - congenital Osteochondrodysplasias - genetics Osteochondrodysplasias - metabolism Osteochondrodysplasias - pathology Receptor Protein-Tyrosine Kinases - metabolism Receptors, Mitogen - metabolism Rheumatology Serine Endopeptidases - metabolism Signal Transduction - physiology Spondyloepiphyseal dysplasia congenita Tibia - pathology Type II collagen mutation Up-Regulation
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