Intracellular pH regulation by Na+/H+ exchanger-1 (NHE1) is required for growth factor-induced mammary branching morphogenesis

Regulation of intracellular pH (pHi) and protection against cytosolic acidification is primarily a function of the ubiquitous plasma membrane Na+/H+exchanger-1 (NHE1), which uses a highly conserved process to transfer cytosolic hydrogen ions (H+) across plasma membranes in exchange for extracellular...

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Veröffentlicht in:	Developmental biology 2012-05, Vol.365 (1), p.71-81
Hauptverfasser:	Jenkins, Edmund C., Debnath, Shawon, Gundry, Stephen, Gundry, Sajini, Uyar, Umit, Fata, Jimmie E.
Format:	Artikel
Sprache:	eng
Schlagworte:	acidification Amiloride - analogs & derivatives Amiloride - pharmacology Animals Branching morphogenesis Cation Transport Proteins - physiology Female hydrogen ions Hydrogen-Ion Concentration Intracellular pH ions Keratin-6 Mammary development Mammary Glands, Animal - embryology Mammary Glands, Animal - physiology Mice mitogen-activated protein kinase morphogenesis Morphogenesis - drug effects Morphogenesis - physiology NHE1 Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology plasma membrane protons Signal Transduction sodium Sodium hydrogen exchanger Sodium-Hydrogen Exchanger 1 Sodium-Hydrogen Exchangers - physiology Transforming Growth Factor alpha - physiology Transforming growth factor-alpha
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