A selective metabolite array for the detection of phosphometabolites
[Display omitted] ► Metal affinity based selective array for the screening of phosphometabolites. ► A simple one-step plasma polymer coating and direct metal immobilisation. ► ToF-SIMS detection of phosphometabolite array. ► Ga and Zr suitable metals. Immobilised metal ion affinity (IMA) has been tr...
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| Veröffentlicht in: | Analytica chimica acta 2012-04, Vol.724, p.119-126 |
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| container_title | Analytica chimica acta |
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| creator | Salim, Malinda Fowler, Gregory J.S. Wright, Phillip C. Vaidyanathan, Seetharaman |
| description | [Display omitted]
► Metal affinity based selective array for the screening of phosphometabolites. ► A simple one-step plasma polymer coating and direct metal immobilisation. ► ToF-SIMS detection of phosphometabolite array. ► Ga and Zr suitable metals.
Immobilised metal ion affinity (IMA) has been traditionally used specifically for the separation of phosphorylated proteins and nucleic acids, in proteomics and genomics, respectively. This report describes the novel application of IMA in metabolomics for the development of metabolite arrays to detect phosphometabolites using a plasma polymer-modified surface. Immobilisation of gallium, zirconium, cobalt, copper, zinc, nickel, iron, and chromium to acrylic acid plasma polymer followed by subsequent exposure to metabolites (phospho- and non-phosphometabolites) was investigated. Results analysed using ToF-SIMS suggests that gallium and zirconium exhibit higher phosphometabolite affinity and specificity compared to other metals, and can be used to develop metabolite arrays for the detection of phosphometabolites. |
| doi_str_mv | 10.1016/j.aca.2012.02.024 |
| format | Article |
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► Metal affinity based selective array for the screening of phosphometabolites. ► A simple one-step plasma polymer coating and direct metal immobilisation. ► ToF-SIMS detection of phosphometabolite array. ► Ga and Zr suitable metals.
Immobilised metal ion affinity (IMA) has been traditionally used specifically for the separation of phosphorylated proteins and nucleic acids, in proteomics and genomics, respectively. This report describes the novel application of IMA in metabolomics for the development of metabolite arrays to detect phosphometabolites using a plasma polymer-modified surface. Immobilisation of gallium, zirconium, cobalt, copper, zinc, nickel, iron, and chromium to acrylic acid plasma polymer followed by subsequent exposure to metabolites (phospho- and non-phosphometabolites) was investigated. Results analysed using ToF-SIMS suggests that gallium and zirconium exhibit higher phosphometabolite affinity and specificity compared to other metals, and can be used to develop metabolite arrays for the detection of phosphometabolites.</description><identifier>ISSN: 0003-2670</identifier><identifier>EISSN: 1873-4324</identifier><identifier>DOI: 10.1016/j.aca.2012.02.024</identifier><identifier>PMID: 22483219</identifier><identifier>CODEN: ACACAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acrylic acid ; Acrylic Resins - chemistry ; Adsorption ; Affinity ; Analytical chemistry ; Arrays ; Biological and medical sciences ; Biomimetic Materials - analysis ; Chemistry ; Diverse techniques ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; Gallium - chemistry ; Iron ; Mathematical analysis ; Metabolite profiling ; Metabolites ; Metabolome ; Metabolomics ; Metabolomics - methods ; Metal affinity ; Molecular and cellular biology ; Organophosphates - analysis ; Phosphate ; Plasma Gases ; Principal Component Analysis ; Secondary ion mass spectrometry ; Solutions ; Spectrometric and optical methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Zinc ; Zirconium ; Zirconium - chemistry</subject><ispartof>Analytica chimica acta, 2012-04, Vol.724, p.119-126</ispartof><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-30b9dee2fa681e579235e685ed1432d4883a7ae12f23f9b567baf0a78fa925d63</citedby><cites>FETCH-LOGICAL-c415t-30b9dee2fa681e579235e685ed1432d4883a7ae12f23f9b567baf0a78fa925d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.aca.2012.02.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25777275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22483219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salim, Malinda</creatorcontrib><creatorcontrib>Fowler, Gregory J.S.</creatorcontrib><creatorcontrib>Wright, Phillip C.</creatorcontrib><creatorcontrib>Vaidyanathan, Seetharaman</creatorcontrib><title>A selective metabolite array for the detection of phosphometabolites</title><title>Analytica chimica acta</title><addtitle>Anal Chim Acta</addtitle><description>[Display omitted]
► Metal affinity based selective array for the screening of phosphometabolites. ► A simple one-step plasma polymer coating and direct metal immobilisation. ► ToF-SIMS detection of phosphometabolite array. ► Ga and Zr suitable metals.
Immobilised metal ion affinity (IMA) has been traditionally used specifically for the separation of phosphorylated proteins and nucleic acids, in proteomics and genomics, respectively. This report describes the novel application of IMA in metabolomics for the development of metabolite arrays to detect phosphometabolites using a plasma polymer-modified surface. Immobilisation of gallium, zirconium, cobalt, copper, zinc, nickel, iron, and chromium to acrylic acid plasma polymer followed by subsequent exposure to metabolites (phospho- and non-phosphometabolites) was investigated. Results analysed using ToF-SIMS suggests that gallium and zirconium exhibit higher phosphometabolite affinity and specificity compared to other metals, and can be used to develop metabolite arrays for the detection of phosphometabolites.</description><subject>Acrylic acid</subject><subject>Acrylic Resins - chemistry</subject><subject>Adsorption</subject><subject>Affinity</subject><subject>Analytical chemistry</subject><subject>Arrays</subject><subject>Biological and medical sciences</subject><subject>Biomimetic Materials - analysis</subject><subject>Chemistry</subject><subject>Diverse techniques</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gallium - chemistry</subject><subject>Iron</subject><subject>Mathematical analysis</subject><subject>Metabolite profiling</subject><subject>Metabolites</subject><subject>Metabolome</subject><subject>Metabolomics</subject><subject>Metabolomics - methods</subject><subject>Metal affinity</subject><subject>Molecular and cellular biology</subject><subject>Organophosphates - analysis</subject><subject>Phosphate</subject><subject>Plasma Gases</subject><subject>Principal Component Analysis</subject><subject>Secondary ion mass spectrometry</subject><subject>Solutions</subject><subject>Spectrometric and optical methods</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Zinc</subject><subject>Zirconium</subject><subject>Zirconium - chemistry</subject><issn>0003-2670</issn><issn>1873-4324</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LJDEQhsOyss6qP8CL9GVxLz2bykenG0-i-yEIe9k9h-p0BTP0TMakR_Dfm2ZGvQlVFAVPvRQPY-fAl8Ch-bFaosOl4CCWfC71iS2gNbJWUqjPbME5l7VoDD9mX3NelVUAV1_YsRCqlQK6Bbu9rjKN5KbwRNWaJuzjGCaqMCV8rnxM1fRA1UDTjMRNFX21fYi59DucT9mRxzHT2WGesP-_fv67-VPf__19d3N9XzsFeqol77uBSHhsWiBtOiE1Na2mAcrDg2pbiQYJhBfSd71uTI-eo2k9dkIPjTxhl_vcbYqPO8qTXYfsaBxxQ3GXbddJ4EIrKOT3D0loDGjZNXwOhT3qUsw5kbfbFNaYni1wO2u2K1s021mz5XOpcnNxiN_1axreLl69FuDbAcDscPQJNy7kd04bY4TRhbvac1S0PQVKNrtAG0dDSMW4HWL44I0X7iuZOA</recordid><startdate>20120429</startdate><enddate>20120429</enddate><creator>Salim, Malinda</creator><creator>Fowler, Gregory J.S.</creator><creator>Wright, Phillip C.</creator><creator>Vaidyanathan, Seetharaman</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20120429</creationdate><title>A selective metabolite array for the detection of phosphometabolites</title><author>Salim, Malinda ; Fowler, Gregory J.S. ; Wright, Phillip C. ; Vaidyanathan, Seetharaman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-30b9dee2fa681e579235e685ed1432d4883a7ae12f23f9b567baf0a78fa925d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acrylic acid</topic><topic>Acrylic Resins - chemistry</topic><topic>Adsorption</topic><topic>Affinity</topic><topic>Analytical chemistry</topic><topic>Arrays</topic><topic>Biological and medical sciences</topic><topic>Biomimetic Materials - analysis</topic><topic>Chemistry</topic><topic>Diverse techniques</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gallium - chemistry</topic><topic>Iron</topic><topic>Mathematical analysis</topic><topic>Metabolite profiling</topic><topic>Metabolites</topic><topic>Metabolome</topic><topic>Metabolomics</topic><topic>Metabolomics - methods</topic><topic>Metal affinity</topic><topic>Molecular and cellular biology</topic><topic>Organophosphates - analysis</topic><topic>Phosphate</topic><topic>Plasma Gases</topic><topic>Principal Component Analysis</topic><topic>Secondary ion mass spectrometry</topic><topic>Solutions</topic><topic>Spectrometric and optical methods</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><topic>Zinc</topic><topic>Zirconium</topic><topic>Zirconium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salim, Malinda</creatorcontrib><creatorcontrib>Fowler, Gregory J.S.</creatorcontrib><creatorcontrib>Wright, Phillip C.</creatorcontrib><creatorcontrib>Vaidyanathan, Seetharaman</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Analytica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salim, Malinda</au><au>Fowler, Gregory J.S.</au><au>Wright, Phillip C.</au><au>Vaidyanathan, Seetharaman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A selective metabolite array for the detection of phosphometabolites</atitle><jtitle>Analytica chimica acta</jtitle><addtitle>Anal Chim Acta</addtitle><date>2012-04-29</date><risdate>2012</risdate><volume>724</volume><spage>119</spage><epage>126</epage><pages>119-126</pages><issn>0003-2670</issn><eissn>1873-4324</eissn><coden>ACACAM</coden><abstract>[Display omitted]
► Metal affinity based selective array for the screening of phosphometabolites. ► A simple one-step plasma polymer coating and direct metal immobilisation. ► ToF-SIMS detection of phosphometabolite array. ► Ga and Zr suitable metals.
Immobilised metal ion affinity (IMA) has been traditionally used specifically for the separation of phosphorylated proteins and nucleic acids, in proteomics and genomics, respectively. This report describes the novel application of IMA in metabolomics for the development of metabolite arrays to detect phosphometabolites using a plasma polymer-modified surface. Immobilisation of gallium, zirconium, cobalt, copper, zinc, nickel, iron, and chromium to acrylic acid plasma polymer followed by subsequent exposure to metabolites (phospho- and non-phosphometabolites) was investigated. Results analysed using ToF-SIMS suggests that gallium and zirconium exhibit higher phosphometabolite affinity and specificity compared to other metals, and can be used to develop metabolite arrays for the detection of phosphometabolites.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>22483219</pmid><doi>10.1016/j.aca.2012.02.024</doi><tpages>8</tpages></addata></record> |
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| subjects | Acrylic acid Acrylic Resins - chemistry Adsorption Affinity Analytical chemistry Arrays Biological and medical sciences Biomimetic Materials - analysis Chemistry Diverse techniques Exact sciences and technology Fundamental and applied biological sciences. Psychology Gallium - chemistry Iron Mathematical analysis Metabolite profiling Metabolites Metabolome Metabolomics Metabolomics - methods Metal affinity Molecular and cellular biology Organophosphates - analysis Phosphate Plasma Gases Principal Component Analysis Secondary ion mass spectrometry Solutions Spectrometric and optical methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Zinc Zirconium Zirconium - chemistry |
| title | A selective metabolite array for the detection of phosphometabolites |
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