Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112

► Rev-erbα links the steroid biosynthesis as well as the cellular clock in ovaries. ► The agonist of Rev-erbα, GSK4112, suppresses Bmal1 mRNA expression. ► GSK4112 enhances StAR expression, but not Lhr expression. ► GSK4112 also induces the Per2-dLuc oscillation phase advance shift. The Rev-erbα gen...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-04, Vol.420 (2), p.374-379
Hauptverfasser:	Chen, Huatao, Chu, Guiyan, Zhao, Lijia, Yamauchi, Nobuhiko, Shigeyoshi, Yasufumi, Hashimoto, Seiichi, Hattori, Masa-aki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARNTL Transcription Factors - antagonists & inhibitors ARNTL Transcription Factors - biosynthesis Circadian rhythm Circadian Rhythm - genetics Female Gene Expression Regulation Glycine - analogs & derivatives Glycine - pharmacology Granulosa cell Granulosa Cells - metabolism Granulosa Cells - physiology GSK4112 Nuclear Receptor Subfamily 1, Group D, Member 1 - agonists Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism Period Circadian Proteins - genetics Period Circadian Proteins - metabolism Phosphoproteins - genetics Promoter Regions, Genetic Rats Rev-erbα StAR Thiophenes - pharmacology
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