Molecular and serum markers in hepatocellular carcinoma: Predictive tools for prognosis and recurrence
Abstract With increased understanding of cancer biology, a multitude of pathological, genetic, and molecular events that drive hepatocarcinogenesis, including angiogenesis, invasion, and metastasis, has been identified. Lately, they are being aggressively evaluated due to challenges involved in esta...
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| Veröffentlicht in: | Critical reviews in oncology/hematology 2012-05, Vol.82 (2), p.116-140 |
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| creator | Singhal, Ashish Jayaraman, Muralidharan Dhanasekaran, Danny N Kohli, Vivek |
| description | Abstract With increased understanding of cancer biology, a multitude of pathological, genetic, and molecular events that drive hepatocarcinogenesis, including angiogenesis, invasion, and metastasis, has been identified. Lately, they are being aggressively evaluated due to challenges involved in establishing early diagnosis, optimizing therapy for cancer inducing hepatotrophic viruses, minimizing the emergence of new tumors, and preventing recurrence after surgical resection or liver transplantation. This comprehensive review examines and critiques the evidence from published manuscripts reporting various tissue and serum biomarkers involved in hepatocellular carcinoma. These markers not only help in prediction of prognosis or recurrence, but may also assist in deciding appropriate modality of therapy and represent novel targets for potential therapeutic agents. |
| doi_str_mv | 10.1016/j.critrevonc.2011.05.005 |
| format | Article |
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Lately, they are being aggressively evaluated due to challenges involved in establishing early diagnosis, optimizing therapy for cancer inducing hepatotrophic viruses, minimizing the emergence of new tumors, and preventing recurrence after surgical resection or liver transplantation. This comprehensive review examines and critiques the evidence from published manuscripts reporting various tissue and serum biomarkers involved in hepatocellular carcinoma. These markers not only help in prediction of prognosis or recurrence, but may also assist in deciding appropriate modality of therapy and represent novel targets for potential therapeutic agents.</description><identifier>ISSN: 1040-8428</identifier><identifier>EISSN: 1879-0461</identifier><identifier>DOI: 10.1016/j.critrevonc.2011.05.005</identifier><identifier>PMID: 21680198</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Antigens, Neoplasm - metabolism ; Biological and medical sciences ; Biomarkers ; Biomarkers, Tumor - blood ; Cancer ; Carcinoma ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - genetics ; Cell Adhesion ; Extracellular Matrix - metabolism ; Gastroenterology. Liver. Pancreas. Abdomen ; Genetic ; HCC ; Hematologic and hematopoietic diseases ; Hematology, Oncology and Palliative Medicine ; Hepatocellular ; Humans ; Intercellular Signaling Peptides and Proteins - metabolism ; Liver ; Liver Neoplasms - blood ; Liver Neoplasms - genetics ; Liver Neoplasms - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Markers ; Medical sciences ; miRNA ; Molecular ; Neovascularization, Pathologic ; Prognosis ; Recurrence ; Serum ; Survival ; Tissue ; Tumors</subject><ispartof>Critical reviews in oncology/hematology, 2012-05, Vol.82 (2), p.116-140</ispartof><rights>2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011. Published by Elsevier Ireland Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-56af6af17e96858df6406edc3191c26a7b67faa77cdc78ef92d3a316bac5b78c3</citedby><cites>FETCH-LOGICAL-c524t-56af6af17e96858df6406edc3191c26a7b67faa77cdc78ef92d3a316bac5b78c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1040842811001375$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25795519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21680198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singhal, Ashish</creatorcontrib><creatorcontrib>Jayaraman, Muralidharan</creatorcontrib><creatorcontrib>Dhanasekaran, Danny N</creatorcontrib><creatorcontrib>Kohli, Vivek</creatorcontrib><title>Molecular and serum markers in hepatocellular carcinoma: Predictive tools for prognosis and recurrence</title><title>Critical reviews in oncology/hematology</title><addtitle>Crit Rev Oncol Hematol</addtitle><description>Abstract With increased understanding of cancer biology, a multitude of pathological, genetic, and molecular events that drive hepatocarcinogenesis, including angiogenesis, invasion, and metastasis, has been identified. Lately, they are being aggressively evaluated due to challenges involved in establishing early diagnosis, optimizing therapy for cancer inducing hepatotrophic viruses, minimizing the emergence of new tumors, and preventing recurrence after surgical resection or liver transplantation. This comprehensive review examines and critiques the evidence from published manuscripts reporting various tissue and serum biomarkers involved in hepatocellular carcinoma. These markers not only help in prediction of prognosis or recurrence, but may also assist in deciding appropriate modality of therapy and represent novel targets for potential therapeutic agents.</description><subject>Antigens, Neoplasm - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Cell Adhesion</subject><subject>Extracellular Matrix - metabolism</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genetic</subject><subject>HCC</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hepatocellular</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Liver</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Markers</subject><subject>Medical sciences</subject><subject>miRNA</subject><subject>Molecular</subject><subject>Neovascularization, Pathologic</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Serum</subject><subject>Survival</subject><subject>Tissue</subject><subject>Tumors</subject><issn>1040-8428</issn><issn>1879-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2LFDEQhhtR3HX1L0gu4qnbSnfny4Ogi1-woqCeQ6a6WjPbk4xJ98D-e9M7owuehEByeOqtykNVFePQcODyxbbB5OdEhxiwaYHzBkQDIO5V51wrU0Mv-f3yhh5q3bf6rHqU8xYA-l6qh9VZy6UGbvR5NX6KE-EyucRcGFimtOzYzqVrSpn5wH7S3s0RaZpuGXQJfYg795J9STR4nP2B2BzjlNkYE9un-CPE7PNtWirJKVFAelw9GN2U6cnpvqi-v3v77fJDffX5_cfL11c1irafayHdWA5XZKQWehhlD5IG7Ljh2EqnNlKNzimFAypNo2mHznVcbhyKjdLYXVTPj7llkF8L5dnufF6nd4Hikq0xXRHIDRRSH0lMMedEo90nXz5-YznYVbLd2jvJdpVsQdgiuZQ-PTVZNjsa_hb-sVqAZyfAZXTTmFxAn-84oYwQ3BTuzZGjouTgKdmMftU1-KJutkP0_zPNq39CcPLBl77XdEN5G5cUinLLbW4t2K_rUqw7wTkA75TofgP6R7dj</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Singhal, Ashish</creator><creator>Jayaraman, Muralidharan</creator><creator>Dhanasekaran, Danny N</creator><creator>Kohli, Vivek</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Molecular and serum markers in hepatocellular carcinoma: Predictive tools for prognosis and recurrence</title><author>Singhal, Ashish ; Jayaraman, Muralidharan ; Dhanasekaran, Danny N ; Kohli, Vivek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-56af6af17e96858df6406edc3191c26a7b67faa77cdc78ef92d3a316bac5b78c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antigens, Neoplasm - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Cancer</topic><topic>Carcinoma</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Cell Adhesion</topic><topic>Extracellular Matrix - metabolism</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genetic</topic><topic>HCC</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hepatocellular</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Liver</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Markers</topic><topic>Medical sciences</topic><topic>miRNA</topic><topic>Molecular</topic><topic>Neovascularization, Pathologic</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Serum</topic><topic>Survival</topic><topic>Tissue</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singhal, Ashish</creatorcontrib><creatorcontrib>Jayaraman, Muralidharan</creatorcontrib><creatorcontrib>Dhanasekaran, Danny N</creatorcontrib><creatorcontrib>Kohli, Vivek</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical reviews in oncology/hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singhal, Ashish</au><au>Jayaraman, Muralidharan</au><au>Dhanasekaran, Danny N</au><au>Kohli, Vivek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular and serum markers in hepatocellular carcinoma: Predictive tools for prognosis and recurrence</atitle><jtitle>Critical reviews in oncology/hematology</jtitle><addtitle>Crit Rev Oncol Hematol</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>82</volume><issue>2</issue><spage>116</spage><epage>140</epage><pages>116-140</pages><issn>1040-8428</issn><eissn>1879-0461</eissn><abstract>Abstract With increased understanding of cancer biology, a multitude of pathological, genetic, and molecular events that drive hepatocarcinogenesis, including angiogenesis, invasion, and metastasis, has been identified. 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| subjects | Antigens, Neoplasm - metabolism Biological and medical sciences Biomarkers Biomarkers, Tumor - blood Cancer Carcinoma Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - genetics Cell Adhesion Extracellular Matrix - metabolism Gastroenterology. Liver. Pancreas. Abdomen Genetic HCC Hematologic and hematopoietic diseases Hematology, Oncology and Palliative Medicine Hepatocellular Humans Intercellular Signaling Peptides and Proteins - metabolism Liver Liver Neoplasms - blood Liver Neoplasms - genetics Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Markers Medical sciences miRNA Molecular Neovascularization, Pathologic Prognosis Recurrence Serum Survival Tissue Tumors |
| title | Molecular and serum markers in hepatocellular carcinoma: Predictive tools for prognosis and recurrence |
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