Downregulation of the dopamine D2-like receptor in corpus allatum affects juvenile hormone synthesis in Drosophila melanogaster females
In Drosophila, juvenile hormone (JH) is synthesized de novo in the specialized endocrine gland, corpusallatum (CA). Dopamine (DA) controls JH levels by either stimulating or inhibiting its synthesis and degradation depending on the developmental stage. The present study focuses on the role of D2-lik...
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| Veröffentlicht in: | Journal of insect physiology 2012-03, Vol.58 (3), p.348-355 |
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| creator | Gruntenko, N.Е Laukhina, O.V Bogomolova, E.V Karpova, E.K Menshanov, P.N Romanova, I.V Rauschenbach, I.Yu |
| description | In Drosophila, juvenile hormone (JH) is synthesized de novo in the specialized endocrine gland, corpusallatum (CA). Dopamine (DA) controls JH levels by either stimulating or inhibiting its synthesis and degradation depending on the developmental stage. The present study focuses on the role of D2-like receptors in the regulation of JH synthesis by dopamine. We show that D2-like receptors (DD2R) are expressed in CA cells of Drosophila melanogaster females. In addition, the level of JH production was analyzed in D. melanogaster females with decreased DD2R expression in CA (vs. corresponding control flies) by assessing multiple indices of JH synthesis (JH-hydrolyzing activity and stress reactivity of the system of JH metabolism, activity and stress reactivity of the alkaline phosphatase, activity and stress reactivity of the tyrosine decarboxylase). The differential value obtained for each index suggests increased JH production in female flies that downregulate DD2R. Based on these findings, we postulate that the DA inhibiting effect on the JH synthesis in D. melanogaster is mediated at least in part via D2-like receptors. |
| doi_str_mv | 10.1016/j.jinsphys.2011.12.006 |
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Dopamine (DA) controls JH levels by either stimulating or inhibiting its synthesis and degradation depending on the developmental stage. The present study focuses on the role of D2-like receptors in the regulation of JH synthesis by dopamine. We show that D2-like receptors (DD2R) are expressed in CA cells of Drosophila melanogaster females. In addition, the level of JH production was analyzed in D. melanogaster females with decreased DD2R expression in CA (vs. corresponding control flies) by assessing multiple indices of JH synthesis (JH-hydrolyzing activity and stress reactivity of the system of JH metabolism, activity and stress reactivity of the alkaline phosphatase, activity and stress reactivity of the tyrosine decarboxylase). The differential value obtained for each index suggests increased JH production in female flies that downregulate DD2R. Based on these findings, we postulate that the DA inhibiting effect on the JH synthesis in D. melanogaster is mediated at least in part via D2-like receptors.</description><identifier>ISSN: 0022-1910</identifier><identifier>EISSN: 1879-1611</identifier><identifier>DOI: 10.1016/j.jinsphys.2011.12.006</identifier><identifier>PMID: 22206888</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>alkaline phosphatase ; Alkaline Phosphatase - metabolism ; Animals ; Animals, Genetically Modified ; corpora allata ; Corpora Allata - metabolism ; dopamine ; Dopamine - metabolism ; Dopamine D2-like receptor ; Down-Regulation ; Drosophila ; Drosophila melanogaster ; Drosophila melanogaster - metabolism ; Drosophila Proteins - metabolism ; Female ; females ; Heat stress ; Heat-Shock Response ; Juvenile hormone ; juvenile hormones ; Juvenile Hormones - biosynthesis ; metabolism ; receptors ; Receptors, Dopamine D2 - metabolism ; tyrosine ; Tyrosine Decarboxylase - metabolism</subject><ispartof>Journal of insect physiology, 2012-03, Vol.58 (3), p.348-355</ispartof><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-27931f0c4b7f3e45ba25877a9846f2558e8b7414bbcdf483d39972b2f43776073</citedby><cites>FETCH-LOGICAL-c481t-27931f0c4b7f3e45ba25877a9846f2558e8b7414bbcdf483d39972b2f43776073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jinsphys.2011.12.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22206888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruntenko, N.Е</creatorcontrib><creatorcontrib>Laukhina, O.V</creatorcontrib><creatorcontrib>Bogomolova, E.V</creatorcontrib><creatorcontrib>Karpova, E.K</creatorcontrib><creatorcontrib>Menshanov, P.N</creatorcontrib><creatorcontrib>Romanova, I.V</creatorcontrib><creatorcontrib>Rauschenbach, I.Yu</creatorcontrib><title>Downregulation of the dopamine D2-like receptor in corpus allatum affects juvenile hormone synthesis in Drosophila melanogaster females</title><title>Journal of insect physiology</title><addtitle>J Insect Physiol</addtitle><description>In Drosophila, juvenile hormone (JH) is synthesized de novo in the specialized endocrine gland, corpusallatum (CA). Dopamine (DA) controls JH levels by either stimulating or inhibiting its synthesis and degradation depending on the developmental stage. The present study focuses on the role of D2-like receptors in the regulation of JH synthesis by dopamine. We show that D2-like receptors (DD2R) are expressed in CA cells of Drosophila melanogaster females. In addition, the level of JH production was analyzed in D. melanogaster females with decreased DD2R expression in CA (vs. corresponding control flies) by assessing multiple indices of JH synthesis (JH-hydrolyzing activity and stress reactivity of the system of JH metabolism, activity and stress reactivity of the alkaline phosphatase, activity and stress reactivity of the tyrosine decarboxylase). The differential value obtained for each index suggests increased JH production in female flies that downregulate DD2R. Based on these findings, we postulate that the DA inhibiting effect on the JH synthesis in D. melanogaster is mediated at least in part via D2-like receptors.</description><subject>alkaline phosphatase</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>corpora allata</subject><subject>Corpora Allata - metabolism</subject><subject>dopamine</subject><subject>Dopamine - metabolism</subject><subject>Dopamine D2-like receptor</subject><subject>Down-Regulation</subject><subject>Drosophila</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - metabolism</subject><subject>Female</subject><subject>females</subject><subject>Heat stress</subject><subject>Heat-Shock Response</subject><subject>Juvenile hormone</subject><subject>juvenile hormones</subject><subject>Juvenile Hormones - biosynthesis</subject><subject>metabolism</subject><subject>receptors</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>tyrosine</subject><subject>Tyrosine Decarboxylase - metabolism</subject><issn>0022-1910</issn><issn>1879-1611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURS0EotPCLxTvWCXYjhM7O1AHKFIlFm3XluM8zzgkdrCTovmC_jYeTcuyrLw5977ndxC6pKSkhDafhnJwPs37QyoZobSkrCSkeYU2VIq2oA2lr9GGEMYK2lJyhs5TGgghdSPrt-iMMUYaKeUGPW7DHx9ht456ccHjYPGyB9yHWU_OA96yYnS_AEcwMC8hYuexCXFeE9ZjzqwT1taCWRIe1gfwbgS8D3EKOZsOPncll46hbQwpzHs3ajzBqH3Y6bRAxBYmPUJ6h95YPSZ4__ReoPtvX--uroubn99_XH25KQyXdCmYaCtqieGdsBXwutOslkLoVvLGsrqWIDvBKe8601suq75qW8E6ZnklRENEdYE-nnrnGH6vkBY1uWQgf8VDWJNqcz8hvG4z2ZxIkzdPEayao5t0PChK1NGBGtSzA3V0oChT2UEOXj6NWLsJ-n-x56Nn4MMJsDoovYsuqfvb3MCzIM7aun6RYFzQI_H5REA-1oODqJJx4A30LqtaVB_c__b8CydCsHw</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Gruntenko, N.Е</creator><creator>Laukhina, O.V</creator><creator>Bogomolova, E.V</creator><creator>Karpova, E.K</creator><creator>Menshanov, P.N</creator><creator>Romanova, I.V</creator><creator>Rauschenbach, I.Yu</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Downregulation of the dopamine D2-like receptor in corpus allatum affects juvenile hormone synthesis in Drosophila melanogaster females</title><author>Gruntenko, N.Е ; Laukhina, O.V ; Bogomolova, E.V ; Karpova, E.K ; Menshanov, P.N ; Romanova, I.V ; Rauschenbach, I.Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-27931f0c4b7f3e45ba25877a9846f2558e8b7414bbcdf483d39972b2f43776073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>alkaline phosphatase</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>corpora allata</topic><topic>Corpora Allata - metabolism</topic><topic>dopamine</topic><topic>Dopamine - metabolism</topic><topic>Dopamine D2-like receptor</topic><topic>Down-Regulation</topic><topic>Drosophila</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - metabolism</topic><topic>Drosophila Proteins - metabolism</topic><topic>Female</topic><topic>females</topic><topic>Heat stress</topic><topic>Heat-Shock Response</topic><topic>Juvenile hormone</topic><topic>juvenile hormones</topic><topic>Juvenile Hormones - biosynthesis</topic><topic>metabolism</topic><topic>receptors</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>tyrosine</topic><topic>Tyrosine Decarboxylase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gruntenko, N.Е</creatorcontrib><creatorcontrib>Laukhina, O.V</creatorcontrib><creatorcontrib>Bogomolova, E.V</creatorcontrib><creatorcontrib>Karpova, E.K</creatorcontrib><creatorcontrib>Menshanov, P.N</creatorcontrib><creatorcontrib>Romanova, I.V</creatorcontrib><creatorcontrib>Rauschenbach, I.Yu</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of insect physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gruntenko, N.Е</au><au>Laukhina, O.V</au><au>Bogomolova, E.V</au><au>Karpova, E.K</au><au>Menshanov, P.N</au><au>Romanova, I.V</au><au>Rauschenbach, I.Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Downregulation of the dopamine D2-like receptor in corpus allatum affects juvenile hormone synthesis in Drosophila melanogaster females</atitle><jtitle>Journal of insect physiology</jtitle><addtitle>J Insect Physiol</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>58</volume><issue>3</issue><spage>348</spage><epage>355</epage><pages>348-355</pages><issn>0022-1910</issn><eissn>1879-1611</eissn><abstract>In Drosophila, juvenile hormone (JH) is synthesized de novo in the specialized endocrine gland, corpusallatum (CA). Dopamine (DA) controls JH levels by either stimulating or inhibiting its synthesis and degradation depending on the developmental stage. The present study focuses on the role of D2-like receptors in the regulation of JH synthesis by dopamine. We show that D2-like receptors (DD2R) are expressed in CA cells of Drosophila melanogaster females. In addition, the level of JH production was analyzed in D. melanogaster females with decreased DD2R expression in CA (vs. corresponding control flies) by assessing multiple indices of JH synthesis (JH-hydrolyzing activity and stress reactivity of the system of JH metabolism, activity and stress reactivity of the alkaline phosphatase, activity and stress reactivity of the tyrosine decarboxylase). The differential value obtained for each index suggests increased JH production in female flies that downregulate DD2R. Based on these findings, we postulate that the DA inhibiting effect on the JH synthesis in D. melanogaster is mediated at least in part via D2-like receptors.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>22206888</pmid><doi>10.1016/j.jinsphys.2011.12.006</doi><tpages>8</tpages></addata></record> |
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| subjects | alkaline phosphatase Alkaline Phosphatase - metabolism Animals Animals, Genetically Modified corpora allata Corpora Allata - metabolism dopamine Dopamine - metabolism Dopamine D2-like receptor Down-Regulation Drosophila Drosophila melanogaster Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Female females Heat stress Heat-Shock Response Juvenile hormone juvenile hormones Juvenile Hormones - biosynthesis metabolism receptors Receptors, Dopamine D2 - metabolism tyrosine Tyrosine Decarboxylase - metabolism |
| title | Downregulation of the dopamine D2-like receptor in corpus allatum affects juvenile hormone synthesis in Drosophila melanogaster females |
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