Absence of Unspecific Innate Immune Cell Activation by GATA-3-Specific DNAzymes

DNAzymes of the 10-23 family represent an important class of antisense molecules with implications for therapeutic treatment of diseases. These molecules are single-stranded oligodeoxynucleotides combining the high specificity of oligonucleotide base pairing with an inherent RNA-cleaving enzymatic a...

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Veröffentlicht in:	Nucleic acid therapeutics 2012-04, Vol.22 (2), p.117-126
Hauptverfasser:	Dicke, Tanja, Pali-Schöll, Isabella, Kaufmann, Andreas, Bauer, Stefan, Renz, Harald, Garn, Holger
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic diseases Allergies Animals Antisense Asthma Base Sequence Basophils - drug effects Basophils - metabolism Catalytic Domain Cell activation Cells, Cultured CpG islands Cytokines - secretion Degranulation Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - secretion Deoxyribonucleic acid DNA DNA, Catalytic - pharmacology DNA, Single-Stranded - pharmacology Enzymatic activity Enzymes GATA3 Transcription Factor Gene therapy Genes, Reporter Immune system Immune System - cytology Immunity, Innate - drug effects Immunologic Factors - pharmacology Leukocytes (basophilic) Leukocytes (granulocytic) Leukocytes (neutrophilic) Luciferases - biosynthesis Luciferases - genetics Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - secretion Mast cells Mast Cells - drug effects Mast Cells - enzymology Medical treatment Mice Mice, Inbred BALB C Molecular biology Neutrophils - drug effects Neutrophils - metabolism NF-kappa B - genetics Oligonucleotides Original Articles Primary Cell Culture Rats Respiratory Burst - drug effects Spleen - cytology TLR9 protein Toll-Like Receptor 9 - metabolism Toll-like receptors
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