Guanine-Rich RNAs and DNAs That Bind Heme Robustly Catalyze Oxygen Transfer Reactions

Diverse guanine-rich RNAs and DNAs that fold to form guanine quadruplexes are known to form tight complexes with Fe(III) heme. We show here that a wide variety of such complexes robustly catalyze two-electron oxidations, transferring oxygen from hydrogen peroxide to thioanisole, indole, and styrene...

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Veröffentlicht in:	Journal of the American Chemical Society 2011-02, Vol.133 (6), p.1877-1884
Hauptverfasser:	Poon, Lester C.-H., Methot, Stephen P., Morabi-Pazooki, William, Pio, Frédéric, Bennet, Andrew J., Sen, Dipankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde - analogs & derivatives Acetaldehyde - chemistry Catalysis DNA - chemistry G-Quadruplexes Heme - chemistry Hydrogen Peroxide - chemistry Indoles - chemistry Models, Molecular Oxygen - chemistry RNA - chemistry Styrene - chemistry Sulfides - chemistry
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