Thiolated chitosan nanoparticles for the nasal administration of leuprolide: Bioavailability and pharmacokinetic characterization

Improved nasal transport of leuprolide based on thiolated chitosan–thioglycolic acid (chitosan–TGA) nanoparticles (NPs). The purpose of this study was to develop thiolated nanoparticles to enhance the bioavailability for the nasal application of leuprolide. Thiolated chitosan–thioglycolic acid (chit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of pharmaceutics 2012-05, Vol.428 (1-2), p.164-170
Hauptverfasser:	Shahnaz, Gul, Vetter, Anja, Barthelmes, Jan, Rahmat, Deni, Laffleur, Flavia, Iqbal, Javed, Perera, Glen, Schlocker, Wolfgang, Dünnhaput, Sarah, Augustijns, Patrick, Bernkop-Schnürch, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	additives Administration, Intranasal Animals Bioavailability Biological Availability Cells, Cultured Chemistry, Pharmaceutical - methods chitosan Chitosan - administration & dosage Chitosan - chemistry Delayed-Action Preparations Drug Carriers - administration & dosage Drug Carriers - chemistry drug delivery systems Drug Delivery Systems - methods gelation Half-Life Humans intranasal administration Leuprolide Leuprolide - administration & dosage Leuprolide - chemistry Leuprolide - pharmacokinetics Male nanoparticles Nanoparticles (NPs) Nanoparticles - administration & dosage Nanoparticles - chemistry Nasal delivery nasal mucosa Nasal Mucosa - metabolism Particle Size pharmacokinetics Rats Rats, Sprague-Dawley Sulfhydryl Compounds - chemistry Swine Thioglycolates - chemistry Thiolated polymer tripolyphosphates zeta potential
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!