The Strategies Used for Treatment of Experimental Autoimmune Neuritis (EAN): A Beneficial Effect of Glatiramer Acetate Administered Intraperitoneally
Glatiramer acetate (GA) significantly ameliorates multiple sclerosis and was initially discovered through its effects on the animal model experimental autoimmune encephalomyelitis (EAE). Guillain-Barré syndrome (GBS) is a relatively common demyelinating disease of peripheral nerves for which there i...
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| Veröffentlicht in: | Clinical reviews in allergy & immunology 2012-04, Vol.42 (2), p.181-188 |
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| creator | Aronovich, Ramona Katzav, Aviva Chapman, Joab |
| description | Glatiramer acetate (GA) significantly ameliorates multiple sclerosis and was initially discovered through its effects on the animal model experimental autoimmune encephalomyelitis (EAE). Guillain-Barré syndrome (GBS) is a relatively common demyelinating disease of peripheral nerves for which there is a parallel animal model, experimental autoimmune neuritis (EAN). We review the treatments found useful in EAN with special emphasis on the need for quick onset of action and the relevance of treatments used for EAE and multiple sclerosis. We evaluated the effect of GA administered by a novel intraperitoneal route in EAN. GA significantly ameliorated the severity of disease in rats (
F
= 6.3,
p
= 0.01 by analysis of variance (ANOVA)) and course of disease (
F
= 4.9,
p
= 0.02 by repeated-measures ANOVA with a day × treatment interaction term). Neurophysiology data supported the trend for the beneficial effect of GA. Myelin-induced immune cell proliferation was significantly modulated by GA (
p
|
| doi_str_mv | 10.1007/s12016-010-8246-7 |
| format | Article |
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F
= 6.3,
p
= 0.01 by analysis of variance (ANOVA)) and course of disease (
F
= 4.9,
p
= 0.02 by repeated-measures ANOVA with a day × treatment interaction term). Neurophysiology data supported the trend for the beneficial effect of GA. Myelin-induced immune cell proliferation was significantly modulated by GA (
p
< 0.025). This report describes a novel route of administration of GA and a rapid beneficial effect of GA in EAN. GA may be useful in human diseases, such as GBS, where the intravenous route may offer a rapid onset of drug action.</description><identifier>ISSN: 1080-0549</identifier><identifier>EISSN: 1559-0267</identifier><identifier>DOI: 10.1007/s12016-010-8246-7</identifier><identifier>PMID: 21234710</identifier><language>eng</language><publisher>New York: Humana Press Inc</publisher><subject>Allergology ; Analysis ; Animal models ; Animals ; Autoantigens - immunology ; Autoimmune diseases ; Cell proliferation ; Cell Proliferation - drug effects ; Cells, Cultured ; copolymer 1 ; Data processing ; Demyelinating diseases ; Disease Progression ; Drug therapy ; Experimental allergic encephalomyelitis ; Experimental allergic neuritis ; Female ; Glatiramer Acetate ; Guillain-Barre syndrome ; Guillain-Barre Syndrome - drug therapy ; Guillain-Barre Syndrome - immunology ; Humans ; Immunology ; Immunomodulation ; Immunosuppressive agents ; Injections, Intraperitoneal ; Internal Medicine ; Intravenous administration ; Lymphocytes - drug effects ; Medicine ; Medicine & Public Health ; Multiple sclerosis ; Myelin Sheath - immunology ; Neuritis, Autoimmune, Experimental - drug therapy ; Neuritis, Autoimmune, Experimental - immunology ; Neurophysiology ; Peptides - administration & dosage ; Peptides - adverse effects ; Peripheral nerves ; Rats ; Rats, Inbred Lew</subject><ispartof>Clinical reviews in allergy & immunology, 2012-04, Vol.42 (2), p.181-188</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>COPYRIGHT 2012 Springer</rights><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-f768c7cd669b84582bad7c71f04d0dbab9c2cf7e4ee710ffde7cd1f5f426dc5e3</citedby><cites>FETCH-LOGICAL-c500t-f768c7cd669b84582bad7c71f04d0dbab9c2cf7e4ee710ffde7cd1f5f426dc5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12016-010-8246-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12016-010-8246-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21234710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aronovich, Ramona</creatorcontrib><creatorcontrib>Katzav, Aviva</creatorcontrib><creatorcontrib>Chapman, Joab</creatorcontrib><title>The Strategies Used for Treatment of Experimental Autoimmune Neuritis (EAN): A Beneficial Effect of Glatiramer Acetate Administered Intraperitoneally</title><title>Clinical reviews in allergy & immunology</title><addtitle>Clinic Rev Allerg Immunol</addtitle><addtitle>Clin Rev Allergy Immunol</addtitle><description>Glatiramer acetate (GA) significantly ameliorates multiple sclerosis and was initially discovered through its effects on the animal model experimental autoimmune encephalomyelitis (EAE). Guillain-Barré syndrome (GBS) is a relatively common demyelinating disease of peripheral nerves for which there is a parallel animal model, experimental autoimmune neuritis (EAN). We review the treatments found useful in EAN with special emphasis on the need for quick onset of action and the relevance of treatments used for EAE and multiple sclerosis. We evaluated the effect of GA administered by a novel intraperitoneal route in EAN. GA significantly ameliorated the severity of disease in rats (
F
= 6.3,
p
= 0.01 by analysis of variance (ANOVA)) and course of disease (
F
= 4.9,
p
= 0.02 by repeated-measures ANOVA with a day × treatment interaction term). Neurophysiology data supported the trend for the beneficial effect of GA. Myelin-induced immune cell proliferation was significantly modulated by GA (
p
< 0.025). This report describes a novel route of administration of GA and a rapid beneficial effect of GA in EAN. GA may be useful in human diseases, such as GBS, where the intravenous route may offer a rapid onset of drug action.</description><subject>Allergology</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Autoantigens - immunology</subject><subject>Autoimmune diseases</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>copolymer 1</subject><subject>Data processing</subject><subject>Demyelinating diseases</subject><subject>Disease Progression</subject><subject>Drug therapy</subject><subject>Experimental allergic encephalomyelitis</subject><subject>Experimental allergic neuritis</subject><subject>Female</subject><subject>Glatiramer Acetate</subject><subject>Guillain-Barre syndrome</subject><subject>Guillain-Barre Syndrome - drug therapy</subject><subject>Guillain-Barre Syndrome - immunology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Immunomodulation</subject><subject>Immunosuppressive agents</subject><subject>Injections, Intraperitoneal</subject><subject>Internal Medicine</subject><subject>Intravenous administration</subject><subject>Lymphocytes - drug effects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple sclerosis</subject><subject>Myelin Sheath - immunology</subject><subject>Neuritis, Autoimmune, Experimental - drug therapy</subject><subject>Neuritis, Autoimmune, Experimental - immunology</subject><subject>Neurophysiology</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - adverse effects</subject><subject>Peripheral nerves</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><issn>1080-0549</issn><issn>1559-0267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kstu1DAUhiMEohd4ADbIAqnAIuXY48QJu1ANpVJVFkzXlsc5nnGV2IPtSPRBeF8cplyKQF749v3nYv9F8YzCKQUQbyNlQOsSKJQN43UpHhSHtKraElgtHuY1NFBCxduD4ijGGwAGzaJ9XBwwyhZcUDgsvq22SD6noBJuLEZyHbEnxgeyCqjSiC4Rb8jy6w6DnXdqIN2UvB3HySG5winYZCN5veyu3rwjHXmPDo3VNnNLY1D_kJ8PKtmgRgyk05hyLtL1o3U2Jgw534XLBcwZkneohuH2SfHIqCHi07v5uLj-sFydfSwvP51fnHWXpa4AUmlE3Wih-7pu1w2vGrZWvdCCGuA99Gu1bjXTRiBHzM0a02OGqakMZ3WvK1wcF6_2cXfBf5kwJjnaqHEYlEM_RdnWDc2BW8jki7_IGz8Fl4uTLRMNZ7yaoZd7aKMGlNYZn_vSc0jZLWrOF40AnqnTf1B59Dha7ef3y-f3BCd_CLb5hdI2-mFK1rt4H6R7UAcfY0Ajd_nXVLiVFOTsGLl3jMyOkbNjpMia53eNTesR-1-KnxbJANsDMV-5DYbfnf8_6nfXfcti</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Aronovich, Ramona</creator><creator>Katzav, Aviva</creator><creator>Chapman, Joab</creator><general>Humana Press Inc</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20120401</creationdate><title>The Strategies Used for Treatment of Experimental Autoimmune Neuritis (EAN): A Beneficial Effect of Glatiramer Acetate Administered Intraperitoneally</title><author>Aronovich, Ramona ; Katzav, Aviva ; Chapman, Joab</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-f768c7cd669b84582bad7c71f04d0dbab9c2cf7e4ee710ffde7cd1f5f426dc5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Allergology</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Autoantigens - immunology</topic><topic>Autoimmune diseases</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>copolymer 1</topic><topic>Data processing</topic><topic>Demyelinating diseases</topic><topic>Disease Progression</topic><topic>Drug therapy</topic><topic>Experimental allergic encephalomyelitis</topic><topic>Experimental allergic neuritis</topic><topic>Female</topic><topic>Glatiramer Acetate</topic><topic>Guillain-Barre syndrome</topic><topic>Guillain-Barre Syndrome - drug therapy</topic><topic>Guillain-Barre Syndrome - immunology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Immunomodulation</topic><topic>Immunosuppressive agents</topic><topic>Injections, Intraperitoneal</topic><topic>Internal Medicine</topic><topic>Intravenous administration</topic><topic>Lymphocytes - drug effects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple sclerosis</topic><topic>Myelin Sheath - immunology</topic><topic>Neuritis, Autoimmune, Experimental - drug therapy</topic><topic>Neuritis, Autoimmune, Experimental - immunology</topic><topic>Neurophysiology</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - adverse effects</topic><topic>Peripheral nerves</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aronovich, Ramona</creatorcontrib><creatorcontrib>Katzav, Aviva</creatorcontrib><creatorcontrib>Chapman, Joab</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Clinical reviews in allergy & immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aronovich, Ramona</au><au>Katzav, Aviva</au><au>Chapman, Joab</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Strategies Used for Treatment of Experimental Autoimmune Neuritis (EAN): A Beneficial Effect of Glatiramer Acetate Administered Intraperitoneally</atitle><jtitle>Clinical reviews in allergy & immunology</jtitle><stitle>Clinic Rev Allerg Immunol</stitle><addtitle>Clin Rev Allergy Immunol</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>42</volume><issue>2</issue><spage>181</spage><epage>188</epage><pages>181-188</pages><issn>1080-0549</issn><eissn>1559-0267</eissn><abstract>Glatiramer acetate (GA) significantly ameliorates multiple sclerosis and was initially discovered through its effects on the animal model experimental autoimmune encephalomyelitis (EAE). Guillain-Barré syndrome (GBS) is a relatively common demyelinating disease of peripheral nerves for which there is a parallel animal model, experimental autoimmune neuritis (EAN). We review the treatments found useful in EAN with special emphasis on the need for quick onset of action and the relevance of treatments used for EAE and multiple sclerosis. We evaluated the effect of GA administered by a novel intraperitoneal route in EAN. GA significantly ameliorated the severity of disease in rats (
F
= 6.3,
p
= 0.01 by analysis of variance (ANOVA)) and course of disease (
F
= 4.9,
p
= 0.02 by repeated-measures ANOVA with a day × treatment interaction term). Neurophysiology data supported the trend for the beneficial effect of GA. Myelin-induced immune cell proliferation was significantly modulated by GA (
p
< 0.025). This report describes a novel route of administration of GA and a rapid beneficial effect of GA in EAN. GA may be useful in human diseases, such as GBS, where the intravenous route may offer a rapid onset of drug action.</abstract><cop>New York</cop><pub>Humana Press Inc</pub><pmid>21234710</pmid><doi>10.1007/s12016-010-8246-7</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinical reviews in allergy & immunology, 2012-04, Vol.42 (2), p.181-188 |
| issn | 1080-0549 1559-0267 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Allergology Analysis Animal models Animals Autoantigens - immunology Autoimmune diseases Cell proliferation Cell Proliferation - drug effects Cells, Cultured copolymer 1 Data processing Demyelinating diseases Disease Progression Drug therapy Experimental allergic encephalomyelitis Experimental allergic neuritis Female Glatiramer Acetate Guillain-Barre syndrome Guillain-Barre Syndrome - drug therapy Guillain-Barre Syndrome - immunology Humans Immunology Immunomodulation Immunosuppressive agents Injections, Intraperitoneal Internal Medicine Intravenous administration Lymphocytes - drug effects Medicine Medicine & Public Health Multiple sclerosis Myelin Sheath - immunology Neuritis, Autoimmune, Experimental - drug therapy Neuritis, Autoimmune, Experimental - immunology Neurophysiology Peptides - administration & dosage Peptides - adverse effects Peripheral nerves Rats Rats, Inbred Lew |
| title | The Strategies Used for Treatment of Experimental Autoimmune Neuritis (EAN): A Beneficial Effect of Glatiramer Acetate Administered Intraperitoneally |
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