Synthesis, antimicrobial and anticancer activities of a novel series of diphenyl 1-(pyridin-3-yl)ethylphosphonates

A novel series of diphenyl 1-(arylamino)-1-(pyridin-3-yl)ethylphosphonates 1–5 was obtained in high yields from reactions of 3-acetyl pyridine with aromatic amines and triphenylphosphite in the presence of lithium perchlorate as a catalyst. The structures of the synthesized compounds were confirmed...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-04, Vol.20 (7), p.2252-2258
Hauptverfasser:	Abdel-Megeed, Mohamed F., Badr, Badr E., Azaam, Mohamed M., El-Hiti, Gamal A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology anti-infective properties Anticancer anticarcinogenic activity Antimicrobial Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology aromatic amines Bacillus subtilis Biological and medical sciences biphenyl catalysts Cell Line, Tumor Cell Proliferation - drug effects chemistry cytotoxicity Diphenyl 1-(pyridin-3-yl)ethylphosphonates Escherichia coli fungi Fungi - drug effects Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-positive bacteria Gram-Positive Bacteria - drug effects Hep G2 Cells Humans Lethal dose lithium liver Medical sciences Microbial Sensitivity Tests nuclear magnetic resonance spectroscopy Organophosphonates - chemistry Organophosphonates - pharmacology Pharmacology. Drug treatments Phosphorous Acids - chemistry Phosphorous Acids - pharmacology pyridines Pyridines - chemistry Saccharomyces cerevisiae spectral analysis Staphylococcus aureus α-Aminophosphonate
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