Proteasome inhibitors for cancer therapy

Potent, selective and cell-permeable proteasome inhibitors 6 and 7 displayed activity against various rodent and human tumor cell lines (in vitro). Proteasome, a large multicatalytic proteinase complex that plays an important role in processing of proteins, has been shown to possess multiple catalyt...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-04, Vol.20 (7), p.2362-2368
Hauptverfasser:	Iqbal, Mohamed, Messina McLaughlin, Patricia A., Dunn, Derek, Mallya, Satish, Husten, Jean, Ator, Mark A., Chatterjee, Sankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Boronic Acids - chemistry Boronic Acids - pharmacology Boronic Acids - therapeutic use Cancer catalytic activity Cell Line, Tumor Cell Proliferation - drug effects Drug Screening Assays, Antitumor drugs Humans Liver - enzymology Medical sciences Mice Neoplasms - drug therapy Nitro Compounds - chemistry Nitro Compounds - pharmacology Nitro Compounds - therapeutic use Peptidomimetic Pharmacology. Drug treatments Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Proteasome proteasome endopeptidase complex Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors proteinases proteins rodents therapeutics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!