Hepatocyte Growth Factor-Transfected Skeletal Myoblasts to Limit the Development of Postinfarction Heart Failure

Stem cells transplanted to an injured heart affect the host myocardium indirectly. The cytokine hepatocyte growth factor (HGF) may play a key role in this paracrine activity. We hypothesized that HGF‐overexpressing stem cells would restore cardiac function after myocardial infarction (MI). Because t...

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Veröffentlicht in:	Artificial organs 2012-03, Vol.36 (3), p.238-246
Hauptverfasser:	Poppe, Annika, Golsong, Peter, Blumenthal, Britta, von Wattenwyl, Robert, Blanke, Philipp, Beyersdorf, Friedhelm, Schlensak, Christian, Siepe, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animals Cells, Cultured Cytokine Heart Failure - etiology Heart Failure - pathology Heart Failure - therapy Hemodynamics Hepatocyte Growth Factor - genetics Hepatocyte-growth factor Humans Male Myoblasts, Skeletal - metabolism Myoblasts, Skeletal - transplantation Myocardial Infarction - complications Myocardium - pathology Paracrine action Rats Rats, Inbred Lew Stem cell transplantation Tissue Engineering - methods Tissue Scaffolds - chemistry Transfection Up-Regulation
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