Normal or non-diagnostic neuroimaging studies prior to the detection of malignant primary brain tumors
Abstract We aimed to describe a single institution experience of neuroimaging failure to demonstrate malignant primary brain tumors. We retrospectively reviewed case histories for all newly diagnosed adult patients with malignant primary brain tumors treated at a single institution between 1 July 20...
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| Veröffentlicht in: | Journal of clinical neuroscience 2012-03, Vol.19 (3), p.411-414 |
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| creator | Thaler, Paul B Li, Jian Yi Isakov, Yakov Black, Karen S Schulder, Michael Demopoulos, Alexis |
| description | Abstract We aimed to describe a single institution experience of neuroimaging failure to demonstrate malignant primary brain tumors. We retrospectively reviewed case histories for all newly diagnosed adult patients with malignant primary brain tumors treated at a single institution between 1 July 2006 and 30 June 2008. We specifically looked at patients in whom neuroimaging was normal or non-diagnostic at initial presentation. Among 193 patients with malignant primary brain tumors, there were 102 with World Health Organization (WHO) grade IV gliomas (glioblastoma multiforme, GBM), 54 with anaplastic gliomas, 18 with low grade gliomas, and 19 with primary central nervous system lymphomas (PCNSL). Initial imaging was normal in nine patients and abnormal but non-diagnostic in an additional eight patients with primary brain cancer. Normal or non-diagnostic neuroimaging was not uncommon among patients with GBM. Dramatic, rapid tumor growth is possible. Close interval clinical and radiographic follow-up can be important especially in the management of elderly patients presenting with seizures and non-diagnostic neuroimaging studies. |
| doi_str_mv | 10.1016/j.jocn.2011.09.002 |
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We retrospectively reviewed case histories for all newly diagnosed adult patients with malignant primary brain tumors treated at a single institution between 1 July 2006 and 30 June 2008. We specifically looked at patients in whom neuroimaging was normal or non-diagnostic at initial presentation. Among 193 patients with malignant primary brain tumors, there were 102 with World Health Organization (WHO) grade IV gliomas (glioblastoma multiforme, GBM), 54 with anaplastic gliomas, 18 with low grade gliomas, and 19 with primary central nervous system lymphomas (PCNSL). Initial imaging was normal in nine patients and abnormal but non-diagnostic in an additional eight patients with primary brain cancer. Normal or non-diagnostic neuroimaging was not uncommon among patients with GBM. Dramatic, rapid tumor growth is possible. Close interval clinical and radiographic follow-up can be important especially in the management of elderly patients presenting with seizures and non-diagnostic neuroimaging studies.</description><identifier>ISSN: 0967-5868</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1016/j.jocn.2011.09.002</identifier><identifier>PMID: 22277560</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Alcoholism - complications ; Biopsy ; Brain Neoplasms - diagnosis ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - pathology ; Carotid Stenosis - complications ; Carotid Stenosis - diagnosis ; Epilepsy, Complex Partial - complications ; Epilepsy, Complex Partial - diagnosis ; Epilepsy, Tonic-Clonic - diagnosis ; Epilepsy, Tonic-Clonic - pathology ; Female ; Glioblastoma - diagnosis ; Glioblastoma - pathology ; Glioma - diagnosis ; Glioma - diagnostic imaging ; Glioma - pathology ; Humans ; Image Processing, Computer-Assisted ; Immunohistochemistry ; Lymphoma - diagnosis ; Lymphoma - diagnostic imaging ; Lymphoma - pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; MRI ; Myotonic Dystrophy - diagnosis ; Myotonic Dystrophy - pathology ; Neuroimaging ; Neurology ; Oncology ; Paresis - diagnosis ; Paresis - pathology ; Primary brain tumor ; Retrospective Studies ; Seizures - complications ; Seizures - diagnosis ; Tomography, X-Ray Computed ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Journal of clinical neuroscience, 2012-03, Vol.19 (3), p.411-414</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-46d6c8fa9982e75ccff0c62660187d824f493ecbf0b5196d1b5468d0fa485d303</citedby><cites>FETCH-LOGICAL-c442t-46d6c8fa9982e75ccff0c62660187d824f493ecbf0b5196d1b5468d0fa485d303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jocn.2011.09.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22277560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thaler, Paul B</creatorcontrib><creatorcontrib>Li, Jian Yi</creatorcontrib><creatorcontrib>Isakov, Yakov</creatorcontrib><creatorcontrib>Black, Karen S</creatorcontrib><creatorcontrib>Schulder, Michael</creatorcontrib><creatorcontrib>Demopoulos, Alexis</creatorcontrib><title>Normal or non-diagnostic neuroimaging studies prior to the detection of malignant primary brain tumors</title><title>Journal of clinical neuroscience</title><addtitle>J Clin Neurosci</addtitle><description>Abstract We aimed to describe a single institution experience of neuroimaging failure to demonstrate malignant primary brain tumors. We retrospectively reviewed case histories for all newly diagnosed adult patients with malignant primary brain tumors treated at a single institution between 1 July 2006 and 30 June 2008. We specifically looked at patients in whom neuroimaging was normal or non-diagnostic at initial presentation. Among 193 patients with malignant primary brain tumors, there were 102 with World Health Organization (WHO) grade IV gliomas (glioblastoma multiforme, GBM), 54 with anaplastic gliomas, 18 with low grade gliomas, and 19 with primary central nervous system lymphomas (PCNSL). Initial imaging was normal in nine patients and abnormal but non-diagnostic in an additional eight patients with primary brain cancer. Normal or non-diagnostic neuroimaging was not uncommon among patients with GBM. Dramatic, rapid tumor growth is possible. Close interval clinical and radiographic follow-up can be important especially in the management of elderly patients presenting with seizures and non-diagnostic neuroimaging studies.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcoholism - complications</subject><subject>Biopsy</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - pathology</subject><subject>Carotid Stenosis - complications</subject><subject>Carotid Stenosis - diagnosis</subject><subject>Epilepsy, Complex Partial - complications</subject><subject>Epilepsy, Complex Partial - diagnosis</subject><subject>Epilepsy, Tonic-Clonic - diagnosis</subject><subject>Epilepsy, Tonic-Clonic - pathology</subject><subject>Female</subject><subject>Glioblastoma - diagnosis</subject><subject>Glioblastoma - pathology</subject><subject>Glioma - diagnosis</subject><subject>Glioma - diagnostic imaging</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Immunohistochemistry</subject><subject>Lymphoma - diagnosis</subject><subject>Lymphoma - diagnostic imaging</subject><subject>Lymphoma - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Myotonic Dystrophy - diagnosis</subject><subject>Myotonic Dystrophy - pathology</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Paresis - diagnosis</subject><subject>Paresis - pathology</subject><subject>Primary brain tumor</subject><subject>Retrospective Studies</subject><subject>Seizures - complications</subject><subject>Seizures - diagnosis</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>0967-5868</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk-L1TAUxYMoznP0C7iQ7Fy13qRtmoIIMvgPBl2o4C6kyc0ztU3GJB2Yb2_Le7pwoau7-Z0D95xDyFMGNQMmXkz1FE2oOTBWw1AD8HvkwLqGV1x0zX1ygEH0VSeFvCCPcp4AYGgbeEguOOd93wk4EPcxpkXPNCYaYqis18cQc_GGBlxT9Is--nCkuazWY6Y3yW9kibR8R2qxoCk-Bhod3Uz8MehQdmbR6Y6OSftAy7rElB-TB07PGZ-c7yX5-vbNl6v31fWndx-uXl9Xpm15qVphhZFOD4Pk2HfGOAdGcCGAyd5K3rp2aNCMDsaODcKysWuFtOB0KzvbQHNJnp98b1L8uWIuavHZ4DzrgHHNahCS9UIK_n-Ss5ZLaMRG8hNpUsw5oVPnDxUDtRehJrUXofYiFAxqK2ITPTvbr-OC9o_kd_Ib8PIE4BbHrceksvEYDFqftlSVjf7f_q_-kpvZB2_0_APvME9xTWELWjGVuQL1eZ_CvgTGADrGvjW_AIfGr78</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Thaler, Paul B</creator><creator>Li, Jian Yi</creator><creator>Isakov, Yakov</creator><creator>Black, Karen S</creator><creator>Schulder, Michael</creator><creator>Demopoulos, Alexis</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20120301</creationdate><title>Normal or non-diagnostic neuroimaging studies prior to the detection of malignant primary brain tumors</title><author>Thaler, Paul B ; Li, Jian Yi ; Isakov, Yakov ; Black, Karen S ; Schulder, Michael ; Demopoulos, Alexis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-46d6c8fa9982e75ccff0c62660187d824f493ecbf0b5196d1b5468d0fa485d303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcoholism - complications</topic><topic>Biopsy</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Brain Neoplasms - pathology</topic><topic>Carotid Stenosis - complications</topic><topic>Carotid Stenosis - diagnosis</topic><topic>Epilepsy, Complex Partial - complications</topic><topic>Epilepsy, Complex Partial - diagnosis</topic><topic>Epilepsy, Tonic-Clonic - diagnosis</topic><topic>Epilepsy, Tonic-Clonic - pathology</topic><topic>Female</topic><topic>Glioblastoma - diagnosis</topic><topic>Glioblastoma - pathology</topic><topic>Glioma - diagnosis</topic><topic>Glioma - diagnostic imaging</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Immunohistochemistry</topic><topic>Lymphoma - diagnosis</topic><topic>Lymphoma - diagnostic imaging</topic><topic>Lymphoma - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Myotonic Dystrophy - diagnosis</topic><topic>Myotonic Dystrophy - pathology</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Oncology</topic><topic>Paresis - diagnosis</topic><topic>Paresis - pathology</topic><topic>Primary brain tumor</topic><topic>Retrospective Studies</topic><topic>Seizures - complications</topic><topic>Seizures - diagnosis</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thaler, Paul B</creatorcontrib><creatorcontrib>Li, Jian Yi</creatorcontrib><creatorcontrib>Isakov, Yakov</creatorcontrib><creatorcontrib>Black, Karen S</creatorcontrib><creatorcontrib>Schulder, Michael</creatorcontrib><creatorcontrib>Demopoulos, Alexis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thaler, Paul B</au><au>Li, Jian Yi</au><au>Isakov, Yakov</au><au>Black, Karen S</au><au>Schulder, Michael</au><au>Demopoulos, Alexis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal or non-diagnostic neuroimaging studies prior to the detection of malignant primary brain tumors</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>19</volume><issue>3</issue><spage>411</spage><epage>414</epage><pages>411-414</pages><issn>0967-5868</issn><eissn>1532-2653</eissn><abstract>Abstract We aimed to describe a single institution experience of neuroimaging failure to demonstrate malignant primary brain tumors. We retrospectively reviewed case histories for all newly diagnosed adult patients with malignant primary brain tumors treated at a single institution between 1 July 2006 and 30 June 2008. We specifically looked at patients in whom neuroimaging was normal or non-diagnostic at initial presentation. Among 193 patients with malignant primary brain tumors, there were 102 with World Health Organization (WHO) grade IV gliomas (glioblastoma multiforme, GBM), 54 with anaplastic gliomas, 18 with low grade gliomas, and 19 with primary central nervous system lymphomas (PCNSL). Initial imaging was normal in nine patients and abnormal but non-diagnostic in an additional eight patients with primary brain cancer. Normal or non-diagnostic neuroimaging was not uncommon among patients with GBM. Dramatic, rapid tumor growth is possible. Close interval clinical and radiographic follow-up can be important especially in the management of elderly patients presenting with seizures and non-diagnostic neuroimaging studies.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>22277560</pmid><doi>10.1016/j.jocn.2011.09.002</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Alcoholism - complications Biopsy Brain Neoplasms - diagnosis Brain Neoplasms - diagnostic imaging Brain Neoplasms - pathology Carotid Stenosis - complications Carotid Stenosis - diagnosis Epilepsy, Complex Partial - complications Epilepsy, Complex Partial - diagnosis Epilepsy, Tonic-Clonic - diagnosis Epilepsy, Tonic-Clonic - pathology Female Glioblastoma - diagnosis Glioblastoma - pathology Glioma - diagnosis Glioma - diagnostic imaging Glioma - pathology Humans Image Processing, Computer-Assisted Immunohistochemistry Lymphoma - diagnosis Lymphoma - diagnostic imaging Lymphoma - pathology Magnetic Resonance Imaging Male Middle Aged MRI Myotonic Dystrophy - diagnosis Myotonic Dystrophy - pathology Neuroimaging Neurology Oncology Paresis - diagnosis Paresis - pathology Primary brain tumor Retrospective Studies Seizures - complications Seizures - diagnosis Tomography, X-Ray Computed Tumor Suppressor Protein p53 - metabolism |
| title | Normal or non-diagnostic neuroimaging studies prior to the detection of malignant primary brain tumors |
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