Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery

Numerous studies have addressed the controlled pulmonary drug delivery properties of colloidal particles. However, only scant information on the potential of spray-drying for submicron particle preparation is available. By exploiting the advantages of spray-drying, the characteristics of submicron p...

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Veröffentlicht in:	Journal of controlled release 2012-03, Vol.158 (2), p.329-335
Hauptverfasser:	Beck-Broichsitter, Moritz, Schweiger, Christoph, Schmehl, Thomas, Gessler, Tobias, Seeger, Werner, Kissel, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosol aerosols Biological and medical sciences colloidal properties colloids Composite particles Controlled pulmonary drug delivery Desiccation Drug Carriers - chemistry Drug Compounding - methods drugs General pharmacology Lactic Acid - chemistry Lung lungs Medical sciences Microscopy, Confocal Microscopy, Electron, Scanning Microscopy, Electron, Transmission Nano Spray Dryer B-90 nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phosphodiesterase 5 Inhibitors - chemistry Piperazines - chemistry Polyglycolic Acid - chemistry Purines - chemistry Sildenafil Citrate spray drying Submicron particles Sulfones - chemistry
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