Catalysis by molecular iodine: A rapid synthesis of 1,8-dioxo-octahydroxanthenes and their evaluation as potential anticancer agents

A clean synthesis of 1,8-dioxo-octahydroxanthenes as potential anticancer agents, structure elaboration of one compound and crystal structure analysis of another compound is presented. Molecular iodine facilitated the reaction of 5,5-dimethyl-1,3-cyclohexanedione with aromatic aldehydes in iso-propa...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-03, Vol.22 (6), p.2186-2191
Hauptverfasser:	Mulakayala, Naveen, Murthy, P.V.N.S., Rambabu, D., Aeluri, Madhu, Adepu, Raju, Krishna, G.R., Reddy, C. Malla, Prasad, K.R.S., Chaitanya, M., Kumar, Chitta S., Basaveswara Rao, M.V., Pal, Manojit
Format:	Artikel
Sprache:	eng
Schlagworte:	1,8-Dioxo-octahydroxanthene 5,5-Dimethyl-1,3-cyclohexanedione aldehydes Aldehydes - chemistry antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Biological and medical sciences Catalysis catalytic activity Cell Line, Tumor Cell Survival - drug effects crystal structure Crystallography, X-Ray Cyclohexanes - chemistry Drug Screening Assays, Antitumor Humans Hydrogen Bonding Inhibitory Concentration 50 Iodine Iodine - chemistry Medical sciences Molecular Structure Neoplasms - drug therapy Neoplasms - pathology Pharmacology. Drug treatments Xanthenes - chemical synthesis Xanthenes - pharmacology
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