Refining the diagnosis of T-cell large granular lymphocytic leukemia by combining distinct patterns of antigen expression with T-cell clonality studies
T-cell large granular lymphocytic (LGL) leukemia is a complex diagnosis, requiring persistent clonal expansions of LGLs, and cytopenias. Often the diagnosis is unclear as non-clonal expansions of LGLs commonly occur in reactive conditions. To better understand T-LGL leukemia, we performed a comprehe...
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| Veröffentlicht in: | Leukemia 2011-09, Vol.25 (9), p.1439-1443 |
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| description | T-cell large granular lymphocytic (LGL) leukemia is a complex diagnosis, requiring persistent clonal expansions of LGLs, and cytopenias. Often the diagnosis is unclear as non-clonal expansions of LGLs commonly occur in reactive conditions. To better understand T-LGL leukemia, we performed a comprehensive clinicopathologic analysis of 85 patients with LGL expansions. Interestingly, distinct CD8+(dim)/CD57+ populations, seen by flow cytometry, were significantly associated with clonal T-LGL leukemia (
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| doi_str_mv | 10.1038/leu.2011.107 |
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| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_968174048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A268310570</galeid><sourcerecordid>A268310570</sourcerecordid><originalsourceid>FETCH-LOGICAL-c543t-4ad5463a6ad6085e5fc29c68e5e845c854e5b50463c9b76bd307dfca273131183</originalsourceid><addsrcrecordid>eNqFkstu1DAUhiMEoqWwY40sKmBDBjvxLcuq4iZVQkJlHTnOScbFsQfbEcyT8Lo4M1NKURHywrfP5_c55y-KpwSvCK7lGwvzqsKE5J24VxwTKnjJGCP3i2MspSh5U9Gj4lGMVxgvl_xhcVQRToTA-Lj4-RkG44wbUVoD6o0anY8mIj-gy1KDtciqMAIag3JzXiK7nTZrr7fJaJSlv8JkFOq2SPup2wfqTUzG6YQ2KiUIbhdMuWRGcAh-bALEaLxD301aX4to652yJm1RTHNvID4uHgzKRnhymE-KL-_eXp5_KC8-vf94fnZRakbrVFLVM8prxVXPsWTABl01mktgICnTklFgHcMZ0U0neNfXWPSDVpWoSU2IrE-KV_u4m-C_zRBTO5m4fEk58HNsGy6JoJj-n5RSYtlIVmfy-V_klZ9Dzm8HVU0t-QKd_guqOGWikvVO9ECNykJr3OBTUHoRbs8qLmuCmcCZWt1B5dHn7mjvcovz-a0HL_94sAZl0zp6O6fcl3gbfL0HdfAxBhjaTTCTCtuW4HaxX5s90C72yzuR8WeHpOZugv43fO23DLw4ACpqZYfsKm3iDUcZbRq5VKfcczFfuRHCTXXuFP4FYefwHg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2645728348</pqid></control><display><type>article</type><title>Refining the diagnosis of T-cell large granular lymphocytic leukemia by combining distinct patterns of antigen expression with T-cell clonality studies</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Ohgami, R S ; Ohgami, J K ; Pereira, I T ; Gitana, G ; Zehnder, J L ; Arber, D A</creator><creatorcontrib>Ohgami, R S ; Ohgami, J K ; Pereira, I T ; Gitana, G ; Zehnder, J L ; Arber, D A</creatorcontrib><description>T-cell large granular lymphocytic (LGL) leukemia is a complex diagnosis, requiring persistent clonal expansions of LGLs, and cytopenias. Often the diagnosis is unclear as non-clonal expansions of LGLs commonly occur in reactive conditions. To better understand T-LGL leukemia, we performed a comprehensive clinicopathologic analysis of 85 patients with LGL expansions. Interestingly, distinct CD8+(dim)/CD57+ populations, seen by flow cytometry, were significantly associated with clonal T-LGL leukemia (
P
<0.001) as well as neutropenia (median absolute neutrophil count (ANC) 1.45 vs 3.19 × 10
9
/l;
P
=0.0017). Furthermore, cases with distinct CD8+(dim)/CD57+ populations and monoclonal T cells had even lower ANCs (median ANC 1.41 × 10
9
/l;
P
=0.001) compared with cases without these dual criteria. Additionally, complete or partial loss of CD5 expression was independently associated with clonal T-LGL leukemia (
P
<0.001) and neutropenia (median ANC 1.41 vs 2.70 × 10
9
/l;
P
=0.002). This study describes specific immunophenotypic parameters to better define clonal cases of T-LGL leukemia associated with significant neutropenia.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/leu.2011.107</identifier><identifier>PMID: 21617700</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/67/1990/283/1895 ; 692/700/139 ; Adult ; Aged ; Aged, 80 and over ; Antigens ; Autoimmune diseases ; Biological and medical sciences ; Bone marrow ; Cancer Research ; CD5 antigen ; CD57 antigen ; CD8 antigen ; Clone Cells ; Critical Care Medicine ; Cytopenia ; Development and progression ; Diagnosis ; Female ; Flow Cytometry ; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - genetics ; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - immunology ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Immune System - immunology ; Immunophenotyping ; Inflammation - diagnosis ; Inflammation - immunology ; Inflammation - metabolism ; Intensive ; Internal Medicine ; Leukemia ; Leukemia, Large Granular Lymphocytic - diagnosis ; Leukemia, Large Granular Lymphocytic - immunology ; Leukemia, Large Granular Lymphocytic - metabolism ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocytes (neutrophilic) ; Lymphatic leukemia ; Lymphocytes ; Lymphocytes T ; Lymphocytic leukemia ; Male ; Medical diagnosis ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Neutropenia ; Neutropenia - diagnosis ; Neutropenia - immunology ; Neutropenia - metabolism ; Neutrophils ; Oncology ; original-article ; Other diseases. Hematologic involvement in other diseases ; Physiological aspects ; Populations ; Receptors, Antigen, T-Cell, alpha-beta - genetics ; Receptors, Antigen, T-Cell, alpha-beta - metabolism ; T cells ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Transplants & implants ; Young Adult</subject><ispartof>Leukemia, 2011-09, Vol.25 (9), p.1439-1443</ispartof><rights>Macmillan Publishers Limited 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Macmillan Publishers Limited 2011.</rights><rights>Copyright Nature Publishing Group Sep 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-4ad5463a6ad6085e5fc29c68e5e845c854e5b50463c9b76bd307dfca273131183</citedby><cites>FETCH-LOGICAL-c543t-4ad5463a6ad6085e5fc29c68e5e845c854e5b50463c9b76bd307dfca273131183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2011.107$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2011.107$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24549983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21617700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohgami, R S</creatorcontrib><creatorcontrib>Ohgami, J K</creatorcontrib><creatorcontrib>Pereira, I T</creatorcontrib><creatorcontrib>Gitana, G</creatorcontrib><creatorcontrib>Zehnder, J L</creatorcontrib><creatorcontrib>Arber, D A</creatorcontrib><title>Refining the diagnosis of T-cell large granular lymphocytic leukemia by combining distinct patterns of antigen expression with T-cell clonality studies</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>T-cell large granular lymphocytic (LGL) leukemia is a complex diagnosis, requiring persistent clonal expansions of LGLs, and cytopenias. Often the diagnosis is unclear as non-clonal expansions of LGLs commonly occur in reactive conditions. To better understand T-LGL leukemia, we performed a comprehensive clinicopathologic analysis of 85 patients with LGL expansions. Interestingly, distinct CD8+(dim)/CD57+ populations, seen by flow cytometry, were significantly associated with clonal T-LGL leukemia (
P
<0.001) as well as neutropenia (median absolute neutrophil count (ANC) 1.45 vs 3.19 × 10
9
/l;
P
=0.0017). Furthermore, cases with distinct CD8+(dim)/CD57+ populations and monoclonal T cells had even lower ANCs (median ANC 1.41 × 10
9
/l;
P
=0.001) compared with cases without these dual criteria. Additionally, complete or partial loss of CD5 expression was independently associated with clonal T-LGL leukemia (
P
<0.001) and neutropenia (median ANC 1.41 vs 2.70 × 10
9
/l;
P
=0.002). This study describes specific immunophenotypic parameters to better define clonal cases of T-LGL leukemia associated with significant neutropenia.</description><subject>692/699/67/1990/283/1895</subject><subject>692/700/139</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens</subject><subject>Autoimmune diseases</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Cancer Research</subject><subject>CD5 antigen</subject><subject>CD57 antigen</subject><subject>CD8 antigen</subject><subject>Clone Cells</subject><subject>Critical Care Medicine</subject><subject>Cytopenia</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - genetics</subject><subject>Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - immunology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immune System - immunology</subject><subject>Immunophenotyping</subject><subject>Inflammation - diagnosis</subject><subject>Inflammation - immunology</subject><subject>Inflammation - metabolism</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Leukemia, Large Granular Lymphocytic - diagnosis</subject><subject>Leukemia, Large Granular Lymphocytic - immunology</subject><subject>Leukemia, Large Granular Lymphocytic - metabolism</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphatic leukemia</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Lymphocytic leukemia</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neutropenia</subject><subject>Neutropenia - diagnosis</subject><subject>Neutropenia - immunology</subject><subject>Neutropenia - metabolism</subject><subject>Neutrophils</subject><subject>Oncology</subject><subject>original-article</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Physiological aspects</subject><subject>Populations</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - genetics</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - metabolism</subject><subject>T cells</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Transplants & implants</subject><subject>Young Adult</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkstu1DAUhiMEoqWwY40sKmBDBjvxLcuq4iZVQkJlHTnOScbFsQfbEcyT8Lo4M1NKURHywrfP5_c55y-KpwSvCK7lGwvzqsKE5J24VxwTKnjJGCP3i2MspSh5U9Gj4lGMVxgvl_xhcVQRToTA-Lj4-RkG44wbUVoD6o0anY8mIj-gy1KDtciqMAIag3JzXiK7nTZrr7fJaJSlv8JkFOq2SPup2wfqTUzG6YQ2KiUIbhdMuWRGcAh-bALEaLxD301aX4to652yJm1RTHNvID4uHgzKRnhymE-KL-_eXp5_KC8-vf94fnZRakbrVFLVM8prxVXPsWTABl01mktgICnTklFgHcMZ0U0neNfXWPSDVpWoSU2IrE-KV_u4m-C_zRBTO5m4fEk58HNsGy6JoJj-n5RSYtlIVmfy-V_klZ9Dzm8HVU0t-QKd_guqOGWikvVO9ECNykJr3OBTUHoRbs8qLmuCmcCZWt1B5dHn7mjvcovz-a0HL_94sAZl0zp6O6fcl3gbfL0HdfAxBhjaTTCTCtuW4HaxX5s90C72yzuR8WeHpOZugv43fO23DLw4ACpqZYfsKm3iDUcZbRq5VKfcczFfuRHCTXXuFP4FYefwHg</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Ohgami, R S</creator><creator>Ohgami, J K</creator><creator>Pereira, I T</creator><creator>Gitana, G</creator><creator>Zehnder, J L</creator><creator>Arber, D A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Refining the diagnosis of T-cell large granular lymphocytic leukemia by combining distinct patterns of antigen expression with T-cell clonality studies</title><author>Ohgami, R S ; Ohgami, J K ; Pereira, I T ; Gitana, G ; Zehnder, J L ; Arber, D A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-4ad5463a6ad6085e5fc29c68e5e845c854e5b50463c9b76bd307dfca273131183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>692/699/67/1990/283/1895</topic><topic>692/700/139</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens</topic><topic>Autoimmune diseases</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Cancer Research</topic><topic>CD5 antigen</topic><topic>CD57 antigen</topic><topic>CD8 antigen</topic><topic>Clone Cells</topic><topic>Critical Care Medicine</topic><topic>Cytopenia</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - genetics</topic><topic>Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - immunology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immune System - immunology</topic><topic>Immunophenotyping</topic><topic>Inflammation - diagnosis</topic><topic>Inflammation - immunology</topic><topic>Inflammation - metabolism</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Leukemia, Large Granular Lymphocytic - diagnosis</topic><topic>Leukemia, Large Granular Lymphocytic - immunology</topic><topic>Leukemia, Large Granular Lymphocytic - metabolism</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphatic leukemia</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Lymphocytic leukemia</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neutropenia</topic><topic>Neutropenia - diagnosis</topic><topic>Neutropenia - immunology</topic><topic>Neutropenia - metabolism</topic><topic>Neutrophils</topic><topic>Oncology</topic><topic>original-article</topic><topic>Other diseases. Hematologic involvement in other diseases</topic><topic>Physiological aspects</topic><topic>Populations</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - genetics</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - metabolism</topic><topic>T cells</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>Transplants & implants</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohgami, R S</creatorcontrib><creatorcontrib>Ohgami, J K</creatorcontrib><creatorcontrib>Pereira, I T</creatorcontrib><creatorcontrib>Gitana, G</creatorcontrib><creatorcontrib>Zehnder, J L</creatorcontrib><creatorcontrib>Arber, D A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohgami, R S</au><au>Ohgami, J K</au><au>Pereira, I T</au><au>Gitana, G</au><au>Zehnder, J L</au><au>Arber, D A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Refining the diagnosis of T-cell large granular lymphocytic leukemia by combining distinct patterns of antigen expression with T-cell clonality studies</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>25</volume><issue>9</issue><spage>1439</spage><epage>1443</epage><pages>1439-1443</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>T-cell large granular lymphocytic (LGL) leukemia is a complex diagnosis, requiring persistent clonal expansions of LGLs, and cytopenias. Often the diagnosis is unclear as non-clonal expansions of LGLs commonly occur in reactive conditions. To better understand T-LGL leukemia, we performed a comprehensive clinicopathologic analysis of 85 patients with LGL expansions. Interestingly, distinct CD8+(dim)/CD57+ populations, seen by flow cytometry, were significantly associated with clonal T-LGL leukemia (
P
<0.001) as well as neutropenia (median absolute neutrophil count (ANC) 1.45 vs 3.19 × 10
9
/l;
P
=0.0017). Furthermore, cases with distinct CD8+(dim)/CD57+ populations and monoclonal T cells had even lower ANCs (median ANC 1.41 × 10
9
/l;
P
=0.001) compared with cases without these dual criteria. Additionally, complete or partial loss of CD5 expression was independently associated with clonal T-LGL leukemia (
P
<0.001) and neutropenia (median ANC 1.41 vs 2.70 × 10
9
/l;
P
=0.002). This study describes specific immunophenotypic parameters to better define clonal cases of T-LGL leukemia associated with significant neutropenia.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21617700</pmid><doi>10.1038/leu.2011.107</doi><tpages>5</tpages></addata></record> |
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| ispartof | Leukemia, 2011-09, Vol.25 (9), p.1439-1443 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 692/699/67/1990/283/1895 692/700/139 Adult Aged Aged, 80 and over Antigens Autoimmune diseases Biological and medical sciences Bone marrow Cancer Research CD5 antigen CD57 antigen CD8 antigen Clone Cells Critical Care Medicine Cytopenia Development and progression Diagnosis Female Flow Cytometry Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - genetics Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - immunology Hematologic and hematopoietic diseases Hematology Humans Immune System - immunology Immunophenotyping Inflammation - diagnosis Inflammation - immunology Inflammation - metabolism Intensive Internal Medicine Leukemia Leukemia, Large Granular Lymphocytic - diagnosis Leukemia, Large Granular Lymphocytic - immunology Leukemia, Large Granular Lymphocytic - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes (neutrophilic) Lymphatic leukemia Lymphocytes Lymphocytes T Lymphocytic leukemia Male Medical diagnosis Medical sciences Medicine Medicine & Public Health Middle Aged Neutropenia Neutropenia - diagnosis Neutropenia - immunology Neutropenia - metabolism Neutrophils Oncology original-article Other diseases. Hematologic involvement in other diseases Physiological aspects Populations Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - metabolism T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism Transplants & implants Young Adult |
| title | Refining the diagnosis of T-cell large granular lymphocytic leukemia by combining distinct patterns of antigen expression with T-cell clonality studies |
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