Estimation of Acute Toxicity by Fitting a Dose-Time-Response Surface
In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. The results of the test are traditionally summarized by a dose‐response curve, and the time course of effect is...
Gespeichert in:
| Veröffentlicht in: | Risk analysis 1995-04, Vol.15 (2), p.247-252 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 252 |
|---|---|
| container_issue | 2 |
| container_start_page | 247 |
| container_title | Risk analysis |
| container_volume | 15 |
| creator | Sun, Kai Krause, Gary F. Mayer, Foster L. Ellersieck, Mark R. Basu, Asit P. |
| description | In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. The results of the test are traditionally summarized by a dose‐response curve, and the time course of effect is usually ignored for lack of a suitable model. A model which integrates the combined effects of dose and exposure duration on response is derived from the biological mechanisms of aquatic toxicity, and a statistically efficient approach for estimating acute toxicity by fitting the proposed model is developed in this paper. The proposed procedure has been computerized as software and a typical data set is used to illustrate the theory and procedure. The new statistical technique is also tested by a data base of a variety of chemical and fish species. |
| doi_str_mv | 10.1111/j.1539-6924.1995.tb00318.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_968173919</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1660052833</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5047-bc77b6590b67d00d39c7971a7877fdf2809e0382834b7017b401169e1fa2d43c3</originalsourceid><addsrcrecordid>eNqVkVFr2zAUhUXpaLO0P6Fg9tD1xe6VZOlaeymhabNC2SBNGexF2LI8lCVxZsk0-fdTSMhjoXrRw_nuudI5hHyhkNF4bucZFVylUrE8o0qJLFQAnBbZ5oQMjtIpGQBDluacs3Py2fs5AAUQeEbOUChkEgZk_OCDW5bBtaukbZKR6YNNZu3GGRe2SbVNHl0IbvUnKZNx6206c0ubTq1ftytvk5e-a0pjL8inplx4e3m4h-T18WF2_z19_jl5uh89p0ZAjmllECspFFQSa4CaK4MKaYkFYlM3rABlgRes4HmFQLHKgVKpLG1KVufc8CH5uvddd-2_3vqgl84bu1iUK9v2XitZUOSKqkjevEtSKWMScROP6PX7KJdCRtcIftuDpmu972yj112MrttqCnrXi57rXfh6F77e9aIPvehNHL46bOmrpa2Po4cion6319_cwm4_4KynTy8jlmN0SPcOzge7OTqU3V8dn49C__ox0VMlx-q3EPFX_wEoO6nE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13656739</pqid></control><display><type>article</type><title>Estimation of Acute Toxicity by Fitting a Dose-Time-Response Surface</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Sun, Kai ; Krause, Gary F. ; Mayer, Foster L. ; Ellersieck, Mark R. ; Basu, Asit P.</creator><creatorcontrib>Sun, Kai ; Krause, Gary F. ; Mayer, Foster L. ; Ellersieck, Mark R. ; Basu, Asit P.</creatorcontrib><description>In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. The results of the test are traditionally summarized by a dose‐response curve, and the time course of effect is usually ignored for lack of a suitable model. A model which integrates the combined effects of dose and exposure duration on response is derived from the biological mechanisms of aquatic toxicity, and a statistically efficient approach for estimating acute toxicity by fitting the proposed model is developed in this paper. The proposed procedure has been computerized as software and a typical data set is used to illustrate the theory and procedure. The new statistical technique is also tested by a data base of a variety of chemical and fish species.</description><identifier>ISSN: 0272-4332</identifier><identifier>EISSN: 1539-6924</identifier><identifier>DOI: 10.1111/j.1539-6924.1995.tb00318.x</identifier><identifier>PMID: 7597260</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acute toxicity ; Algorithms ; Animals ; Computer programs ; dose time-response surface ; Dose-Response Relationship, Drug ; Environmental Exposure - adverse effects ; Fish ; Fishes ; Fittings ; Likelihood Functions ; Models, Chemical ; Organisms ; quantitative assessment ; Risk analysis ; Sodium Selenite - toxicity ; Software ; Time Factors ; Toxicity ; Toxicology ; Water Pollutants - toxicity</subject><ispartof>Risk analysis, 1995-04, Vol.15 (2), p.247-252</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5047-bc77b6590b67d00d39c7971a7877fdf2809e0382834b7017b401169e1fa2d43c3</citedby><cites>FETCH-LOGICAL-c5047-bc77b6590b67d00d39c7971a7877fdf2809e0382834b7017b401169e1fa2d43c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1539-6924.1995.tb00318.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1539-6924.1995.tb00318.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7597260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Kai</creatorcontrib><creatorcontrib>Krause, Gary F.</creatorcontrib><creatorcontrib>Mayer, Foster L.</creatorcontrib><creatorcontrib>Ellersieck, Mark R.</creatorcontrib><creatorcontrib>Basu, Asit P.</creatorcontrib><title>Estimation of Acute Toxicity by Fitting a Dose-Time-Response Surface</title><title>Risk analysis</title><addtitle>Risk Anal</addtitle><description>In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. The results of the test are traditionally summarized by a dose‐response curve, and the time course of effect is usually ignored for lack of a suitable model. A model which integrates the combined effects of dose and exposure duration on response is derived from the biological mechanisms of aquatic toxicity, and a statistically efficient approach for estimating acute toxicity by fitting the proposed model is developed in this paper. The proposed procedure has been computerized as software and a typical data set is used to illustrate the theory and procedure. The new statistical technique is also tested by a data base of a variety of chemical and fish species.</description><subject>Acute toxicity</subject><subject>Algorithms</subject><subject>Animals</subject><subject>Computer programs</subject><subject>dose time-response surface</subject><subject>Dose-Response Relationship, Drug</subject><subject>Environmental Exposure - adverse effects</subject><subject>Fish</subject><subject>Fishes</subject><subject>Fittings</subject><subject>Likelihood Functions</subject><subject>Models, Chemical</subject><subject>Organisms</subject><subject>quantitative assessment</subject><subject>Risk analysis</subject><subject>Sodium Selenite - toxicity</subject><subject>Software</subject><subject>Time Factors</subject><subject>Toxicity</subject><subject>Toxicology</subject><subject>Water Pollutants - toxicity</subject><issn>0272-4332</issn><issn>1539-6924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkVFr2zAUhUXpaLO0P6Fg9tD1xe6VZOlaeymhabNC2SBNGexF2LI8lCVxZsk0-fdTSMhjoXrRw_nuudI5hHyhkNF4bucZFVylUrE8o0qJLFQAnBbZ5oQMjtIpGQBDluacs3Py2fs5AAUQeEbOUChkEgZk_OCDW5bBtaukbZKR6YNNZu3GGRe2SbVNHl0IbvUnKZNx6206c0ubTq1ftytvk5e-a0pjL8inplx4e3m4h-T18WF2_z19_jl5uh89p0ZAjmllECspFFQSa4CaK4MKaYkFYlM3rABlgRes4HmFQLHKgVKpLG1KVufc8CH5uvddd-2_3vqgl84bu1iUK9v2XitZUOSKqkjevEtSKWMScROP6PX7KJdCRtcIftuDpmu972yj112MrttqCnrXi57rXfh6F77e9aIPvehNHL46bOmrpa2Po4cion6319_cwm4_4KynTy8jlmN0SPcOzge7OTqU3V8dn49C__ox0VMlx-q3EPFX_wEoO6nE</recordid><startdate>199504</startdate><enddate>199504</enddate><creator>Sun, Kai</creator><creator>Krause, Gary F.</creator><creator>Mayer, Foster L.</creator><creator>Ellersieck, Mark R.</creator><creator>Basu, Asit P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope><scope>7ST</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>SOI</scope></search><sort><creationdate>199504</creationdate><title>Estimation of Acute Toxicity by Fitting a Dose-Time-Response Surface</title><author>Sun, Kai ; Krause, Gary F. ; Mayer, Foster L. ; Ellersieck, Mark R. ; Basu, Asit P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5047-bc77b6590b67d00d39c7971a7877fdf2809e0382834b7017b401169e1fa2d43c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Acute toxicity</topic><topic>Algorithms</topic><topic>Animals</topic><topic>Computer programs</topic><topic>dose time-response surface</topic><topic>Dose-Response Relationship, Drug</topic><topic>Environmental Exposure - adverse effects</topic><topic>Fish</topic><topic>Fishes</topic><topic>Fittings</topic><topic>Likelihood Functions</topic><topic>Models, Chemical</topic><topic>Organisms</topic><topic>quantitative assessment</topic><topic>Risk analysis</topic><topic>Sodium Selenite - toxicity</topic><topic>Software</topic><topic>Time Factors</topic><topic>Toxicity</topic><topic>Toxicology</topic><topic>Water Pollutants - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Kai</creatorcontrib><creatorcontrib>Krause, Gary F.</creatorcontrib><creatorcontrib>Mayer, Foster L.</creatorcontrib><creatorcontrib>Ellersieck, Mark R.</creatorcontrib><creatorcontrib>Basu, Asit P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Environment Abstracts</collection><jtitle>Risk analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Kai</au><au>Krause, Gary F.</au><au>Mayer, Foster L.</au><au>Ellersieck, Mark R.</au><au>Basu, Asit P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of Acute Toxicity by Fitting a Dose-Time-Response Surface</atitle><jtitle>Risk analysis</jtitle><addtitle>Risk Anal</addtitle><date>1995-04</date><risdate>1995</risdate><volume>15</volume><issue>2</issue><spage>247</spage><epage>252</epage><pages>247-252</pages><issn>0272-4332</issn><eissn>1539-6924</eissn><abstract>In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. The results of the test are traditionally summarized by a dose‐response curve, and the time course of effect is usually ignored for lack of a suitable model. A model which integrates the combined effects of dose and exposure duration on response is derived from the biological mechanisms of aquatic toxicity, and a statistically efficient approach for estimating acute toxicity by fitting the proposed model is developed in this paper. The proposed procedure has been computerized as software and a typical data set is used to illustrate the theory and procedure. The new statistical technique is also tested by a data base of a variety of chemical and fish species.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7597260</pmid><doi>10.1111/j.1539-6924.1995.tb00318.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0272-4332 |
| ispartof | Risk analysis, 1995-04, Vol.15 (2), p.247-252 |
| issn | 0272-4332 1539-6924 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_968173919 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Acute toxicity Algorithms Animals Computer programs dose time-response surface Dose-Response Relationship, Drug Environmental Exposure - adverse effects Fish Fishes Fittings Likelihood Functions Models, Chemical Organisms quantitative assessment Risk analysis Sodium Selenite - toxicity Software Time Factors Toxicity Toxicology Water Pollutants - toxicity |
| title | Estimation of Acute Toxicity by Fitting a Dose-Time-Response Surface |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T19%3A27%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Estimation%20of%20Acute%20Toxicity%20by%20Fitting%20a%20Dose-Time-Response%20Surface&rft.jtitle=Risk%20analysis&rft.au=Sun,%20Kai&rft.date=1995-04&rft.volume=15&rft.issue=2&rft.spage=247&rft.epage=252&rft.pages=247-252&rft.issn=0272-4332&rft.eissn=1539-6924&rft_id=info:doi/10.1111/j.1539-6924.1995.tb00318.x&rft_dat=%3Cproquest_cross%3E1660052833%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13656739&rft_id=info:pmid/7597260&rfr_iscdi=true |