Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus
► TMT-mediated neurotoxicity is exacerbated by a type I corticosterone receptor (mineralocorticoid receptor) agonist. ► TMT-mediated neurotoxicity is ameliorated by a type I corticosterone receptor (mineralocorticoid receptor) antagonist. ► TMT neurotoxicity is exacerbated by a type II corticosteron...
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| Veröffentlicht in: | Neuroscience letters 2012-03, Vol.511 (2), p.116-119 |
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| container_title | Neuroscience letters |
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| creator | Ogita, Kiyokazu Sugiyama, Chie Acosta, Gabriela Beatriz Kuramoto, Nobuyuki Shuto, Makoto Yoneyama, Masanori Nakamura, Yukary Shiba, Tatsuo Yamaguchi, Taro |
| description | ► TMT-mediated neurotoxicity is exacerbated by a type I corticosterone receptor (mineralocorticoid receptor) agonist. ► TMT-mediated neurotoxicity is ameliorated by a type I corticosterone receptor (mineralocorticoid receptor) antagonist. ► TMT neurotoxicity is exacerbated by a type II corticosterone (glucocorticoid receptor) antagonist. ► Endogenous corticosterone functions as a multi-regulating factor in TMT-mediated neurotoxicity.
The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the murine brain. Earlier studies indicate that TMT-induced neuronal degeneration is enhanced by adrenalectomy and prevented by exogenous glucocorticoid. The aim of this study was to investigate the regulation of TMT neuroxicity by corticosterone receptors including type I (mineralocorticoid receptor, MR) and type II (glucocorticoid receptor, GR) in adult mice. The systemic injection of TMT at the dose of 2.0 or 2.8mg/kg produced a marked elevation in the level of plasma corticosterone that was both dose and time dependent. The MR agonist aldosterone had the ability to exacerbate TMT cytotoxicity in the dentate granule cell layer, whereas its antagonist spironolactone protected neurons from TMT cytotoxicity there. In contrast, the GR antagonist mifepristone exacerbated the TMT cytotoxicity. Taken together, our data suggest TMT cytotoxicity is oppositely regulated by GR and MR signals, being exacerbated by MR activation in adult mice. |
| doi_str_mv | 10.1016/j.neulet.2012.01.052 |
| format | Article |
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The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the murine brain. Earlier studies indicate that TMT-induced neuronal degeneration is enhanced by adrenalectomy and prevented by exogenous glucocorticoid. The aim of this study was to investigate the regulation of TMT neuroxicity by corticosterone receptors including type I (mineralocorticoid receptor, MR) and type II (glucocorticoid receptor, GR) in adult mice. The systemic injection of TMT at the dose of 2.0 or 2.8mg/kg produced a marked elevation in the level of plasma corticosterone that was both dose and time dependent. The MR agonist aldosterone had the ability to exacerbate TMT cytotoxicity in the dentate granule cell layer, whereas its antagonist spironolactone protected neurons from TMT cytotoxicity there. In contrast, the GR antagonist mifepristone exacerbated the TMT cytotoxicity. Taken together, our data suggest TMT cytotoxicity is oppositely regulated by GR and MR signals, being exacerbated by MR activation in adult mice.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2012.01.052</identifier><identifier>PMID: 22309794</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Aldosterone - pharmacology ; Animals ; Corticosterone - blood ; Glucocorticoid receptor hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Mice ; Mineralocorticoid receptor ; Mineralocorticoid Receptor Antagonists - pharmacology ; Receptors, Glucocorticoid - metabolism ; Receptors, Glucocorticoid - physiology ; Receptors, Mineralocorticoid - agonists ; Receptors, Mineralocorticoid - metabolism ; Receptors, Mineralocorticoid - physiology ; Spironolactone - pharmacology ; Trimethyltin ; Trimethyltin Compounds - toxicity</subject><ispartof>Neuroscience letters, 2012-03, Vol.511 (2), p.116-119</ispartof><rights>2012 Elsevier Ireland Ltd</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-f8d2f7d945f1c2217a95210d84f2862328436df40469a488479fe1a03d3785143</citedby><cites>FETCH-LOGICAL-c505t-f8d2f7d945f1c2217a95210d84f2862328436df40469a488479fe1a03d3785143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2012.01.052$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22309794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogita, Kiyokazu</creatorcontrib><creatorcontrib>Sugiyama, Chie</creatorcontrib><creatorcontrib>Acosta, Gabriela Beatriz</creatorcontrib><creatorcontrib>Kuramoto, Nobuyuki</creatorcontrib><creatorcontrib>Shuto, Makoto</creatorcontrib><creatorcontrib>Yoneyama, Masanori</creatorcontrib><creatorcontrib>Nakamura, Yukary</creatorcontrib><creatorcontrib>Shiba, Tatsuo</creatorcontrib><creatorcontrib>Yamaguchi, Taro</creatorcontrib><title>Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>► TMT-mediated neurotoxicity is exacerbated by a type I corticosterone receptor (mineralocorticoid receptor) agonist. ► TMT-mediated neurotoxicity is ameliorated by a type I corticosterone receptor (mineralocorticoid receptor) antagonist. ► TMT neurotoxicity is exacerbated by a type II corticosterone (glucocorticoid receptor) antagonist. ► Endogenous corticosterone functions as a multi-regulating factor in TMT-mediated neurotoxicity.
The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the murine brain. Earlier studies indicate that TMT-induced neuronal degeneration is enhanced by adrenalectomy and prevented by exogenous glucocorticoid. The aim of this study was to investigate the regulation of TMT neuroxicity by corticosterone receptors including type I (mineralocorticoid receptor, MR) and type II (glucocorticoid receptor, GR) in adult mice. The systemic injection of TMT at the dose of 2.0 or 2.8mg/kg produced a marked elevation in the level of plasma corticosterone that was both dose and time dependent. The MR agonist aldosterone had the ability to exacerbate TMT cytotoxicity in the dentate granule cell layer, whereas its antagonist spironolactone protected neurons from TMT cytotoxicity there. In contrast, the GR antagonist mifepristone exacerbated the TMT cytotoxicity. Taken together, our data suggest TMT cytotoxicity is oppositely regulated by GR and MR signals, being exacerbated by MR activation in adult mice.</description><subject>Aldosterone - pharmacology</subject><subject>Animals</subject><subject>Corticosterone - blood</subject><subject>Glucocorticoid receptor hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Mice</subject><subject>Mineralocorticoid receptor</subject><subject>Mineralocorticoid Receptor Antagonists - pharmacology</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>Receptors, Glucocorticoid - physiology</subject><subject>Receptors, Mineralocorticoid - agonists</subject><subject>Receptors, Mineralocorticoid - metabolism</subject><subject>Receptors, Mineralocorticoid - physiology</subject><subject>Spironolactone - pharmacology</subject><subject>Trimethyltin</subject><subject>Trimethyltin Compounds - toxicity</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO1DAQRS0EYpqBP0DIO1YJ5UfieIOERjxGGmk2sLaCXZ52K7GD7SD6B_hu0vTACg0rL-pUXeseQl4yaBmw_s2hjbhOWFsOjLfAWuj4I7Jjg-KN0oo_JjsQIBuhJVyQZ6UcAKBjnXxKLjgXoJWWO_LzdllSCfGO5jRhocnTu2m1yaZcg03B0YwWl5oyHaOjc4iYx-lf4xBpzWHGuj9ONcQmRLdadNQea6rpR7ChHn9De6RzWgvSfdiy7Tgva3lOnvhxKvji_r0kXz68_3z1qbm5_Xh99e6msR10tfGD4145LTvPLOdMjbrjDNwgPR96LvggRe-8BNnrUQ6DVNojG0E4oYaOSXFJXp_vLjl9W7FUM4dicZrGiNufjO4HpoQG9X-SC90Jxk835Zm0OZWS0Ztl62HMR8PAnFSZgzmrMidVBpjZVG1rr-4D1q8zur9Lf9xswNszgFsh3wNmU2zAuHUattKrcSk8nPALFM-pog</recordid><startdate>20120309</startdate><enddate>20120309</enddate><creator>Ogita, Kiyokazu</creator><creator>Sugiyama, Chie</creator><creator>Acosta, Gabriela Beatriz</creator><creator>Kuramoto, Nobuyuki</creator><creator>Shuto, Makoto</creator><creator>Yoneyama, Masanori</creator><creator>Nakamura, Yukary</creator><creator>Shiba, Tatsuo</creator><creator>Yamaguchi, Taro</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20120309</creationdate><title>Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus</title><author>Ogita, Kiyokazu ; Sugiyama, Chie ; Acosta, Gabriela Beatriz ; Kuramoto, Nobuyuki ; Shuto, Makoto ; Yoneyama, Masanori ; Nakamura, Yukary ; Shiba, Tatsuo ; Yamaguchi, Taro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-f8d2f7d945f1c2217a95210d84f2862328436df40469a488479fe1a03d3785143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aldosterone - pharmacology</topic><topic>Animals</topic><topic>Corticosterone - blood</topic><topic>Glucocorticoid receptor hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Mice</topic><topic>Mineralocorticoid receptor</topic><topic>Mineralocorticoid Receptor Antagonists - pharmacology</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>Receptors, Glucocorticoid - physiology</topic><topic>Receptors, Mineralocorticoid - agonists</topic><topic>Receptors, Mineralocorticoid - metabolism</topic><topic>Receptors, Mineralocorticoid - physiology</topic><topic>Spironolactone - pharmacology</topic><topic>Trimethyltin</topic><topic>Trimethyltin Compounds - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogita, Kiyokazu</creatorcontrib><creatorcontrib>Sugiyama, Chie</creatorcontrib><creatorcontrib>Acosta, Gabriela Beatriz</creatorcontrib><creatorcontrib>Kuramoto, Nobuyuki</creatorcontrib><creatorcontrib>Shuto, Makoto</creatorcontrib><creatorcontrib>Yoneyama, Masanori</creatorcontrib><creatorcontrib>Nakamura, Yukary</creatorcontrib><creatorcontrib>Shiba, Tatsuo</creatorcontrib><creatorcontrib>Yamaguchi, Taro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogita, Kiyokazu</au><au>Sugiyama, Chie</au><au>Acosta, Gabriela Beatriz</au><au>Kuramoto, Nobuyuki</au><au>Shuto, Makoto</au><au>Yoneyama, Masanori</au><au>Nakamura, Yukary</au><au>Shiba, Tatsuo</au><au>Yamaguchi, Taro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2012-03-09</date><risdate>2012</risdate><volume>511</volume><issue>2</issue><spage>116</spage><epage>119</epage><pages>116-119</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>► TMT-mediated neurotoxicity is exacerbated by a type I corticosterone receptor (mineralocorticoid receptor) agonist. ► TMT-mediated neurotoxicity is ameliorated by a type I corticosterone receptor (mineralocorticoid receptor) antagonist. ► TMT neurotoxicity is exacerbated by a type II corticosterone (glucocorticoid receptor) antagonist. ► Endogenous corticosterone functions as a multi-regulating factor in TMT-mediated neurotoxicity.
The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the murine brain. Earlier studies indicate that TMT-induced neuronal degeneration is enhanced by adrenalectomy and prevented by exogenous glucocorticoid. The aim of this study was to investigate the regulation of TMT neuroxicity by corticosterone receptors including type I (mineralocorticoid receptor, MR) and type II (glucocorticoid receptor, GR) in adult mice. The systemic injection of TMT at the dose of 2.0 or 2.8mg/kg produced a marked elevation in the level of plasma corticosterone that was both dose and time dependent. The MR agonist aldosterone had the ability to exacerbate TMT cytotoxicity in the dentate granule cell layer, whereas its antagonist spironolactone protected neurons from TMT cytotoxicity there. In contrast, the GR antagonist mifepristone exacerbated the TMT cytotoxicity. Taken together, our data suggest TMT cytotoxicity is oppositely regulated by GR and MR signals, being exacerbated by MR activation in adult mice.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22309794</pmid><doi>10.1016/j.neulet.2012.01.052</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuroscience letters, 2012-03, Vol.511 (2), p.116-119 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aldosterone - pharmacology Animals Corticosterone - blood Glucocorticoid receptor hippocampus Hippocampus - drug effects Hippocampus - metabolism Mice Mineralocorticoid receptor Mineralocorticoid Receptor Antagonists - pharmacology Receptors, Glucocorticoid - metabolism Receptors, Glucocorticoid - physiology Receptors, Mineralocorticoid - agonists Receptors, Mineralocorticoid - metabolism Receptors, Mineralocorticoid - physiology Spironolactone - pharmacology Trimethyltin Trimethyltin Compounds - toxicity |
| title | Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus |
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