Effect of a caspase inhibitor, zVADfmk, on the inhibition of breast cancer cells by herpes simplex virus type 1

The oncolytic effects of herpes simplex virus-1 (HSV-1) are limited, possibly because of premature death of infected cells by apoptosis, which limits the amount of progeny virus that is produced. It has been proposed that inhibition of apoptosis in infected tumor cells would allow increased viral pe...

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Veröffentlicht in:	Cancer gene therapy 2011-10, Vol.18 (10), p.685-694
Hauptverfasser:	Wood, L W, Shillitoe, E J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/82/23 692/699/67/1347 692/700/565/1331 692/700/565/1436 Amino Acid Chloromethyl Ketones - pharmacology Amino Acid Chloromethyl Ketones - therapeutic use Animals Antibodies Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - therapy Care and treatment Caspase Caspase Inhibitors Cell culture Cell death Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cercopithecus aethiops Chemotactic factors Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Female Gene Expression Gene Therapy Genetic aspects Health aspects Herpes simplex Herpes simplex virus Herpes simplex virus 1 Herpes viruses Herpesvirus 1, Human - genetics Humans Monocytes Oncolysis Oncolytic Virotherapy Oncolytic Viruses - physiology original-article Physiological aspects Polymerase chain reaction Progeny Replication Tumor cells Tumors Vero Cells Virus Replication - drug effects Viruses
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