CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer
Colorectal cancer (CRC) incidence increases with age, and early onset of the disease is an indication of genetic predisposition, estimated to cause up to 30% of all cases. To identify genes associated with early-onset CRC, we investigated gene expression levels within a series of young patients with...
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| Veröffentlicht in: | Genes and immunity 2011-12, Vol.12 (8), p.653-662 |
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| creator | Ågesen, T H Berg, M Clancy, T Thiis-Evensen, E Cekaite, L Lind, G E Nesland, J M Bakka, A Mala, T Hauss, H J Fetveit, T Vatn, M H Hovig, E Nesbakken, A Lothe, R A Skotheim, R I |
| description | Colorectal cancer (CRC) incidence increases with age, and early onset of the disease is an indication of genetic predisposition, estimated to cause up to 30% of all cases. To identify genes associated with early-onset CRC, we investigated gene expression levels within a series of young patients with CRCs who are not known to carry any hereditary syndromes (
n
=24; mean 43 years at diagnosis), and compared this with a series of CRCs from patients diagnosed at an older age (
n
=17; mean 79 years). Two individual genes were found to be differentially expressed between the two groups, with statistical significance;
CLC
was higher and
IFNAR1
was less expressed in early-onset CRCs. Furthermore, genes located at chromosome band 19q13 were found to be enriched significantly among the genes with higher expression in the early-onset samples, including
CLC
. An elevated immune content within the early-onset group was observed from the differentially expressed genes. By application of outlier statistics,
H3F3A
was identified as a top candidate gene for a subset of the early-onset CRCs. In conclusion,
CLC
and
IFNAR1
were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. |
| doi_str_mv | 10.1038/gene.2011.43 |
| format | Article |
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n
=24; mean 43 years at diagnosis), and compared this with a series of CRCs from patients diagnosed at an older age (
n
=17; mean 79 years). Two individual genes were found to be differentially expressed between the two groups, with statistical significance;
CLC
was higher and
IFNAR1
was less expressed in early-onset CRCs. Furthermore, genes located at chromosome band 19q13 were found to be enriched significantly among the genes with higher expression in the early-onset samples, including
CLC
. An elevated immune content within the early-onset group was observed from the differentially expressed genes. By application of outlier statistics,
H3F3A
was identified as a top candidate gene for a subset of the early-onset CRCs. In conclusion,
CLC
and
IFNAR1
were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC.</description><identifier>ISSN: 1466-4879</identifier><identifier>EISSN: 1476-5470</identifier><identifier>DOI: 10.1038/gene.2011.43</identifier><identifier>PMID: 21716316</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/199 ; 631/208/727/2000 ; 692/699/67/1504/1885 ; Adult ; Age ; Age of Onset ; Aged ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cluster Analysis ; Colorectal cancer ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - immunology ; Disease prevention ; Gastrointestinal surgery ; Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genetic aspects ; Geriatrics ; Glycoproteins - genetics ; Glycoproteins - metabolism ; Health risk assessment ; Hospitals ; Human Genetics ; Humans ; Immunity ; Immunology ; Informatics ; Interferon ; Lysophospholipase - genetics ; Lysophospholipase - metabolism ; Medical research ; Middle Aged ; Neoplasm Staging ; original-article ; Physiological aspects ; Polymerase chain reaction ; Receptor, Interferon alpha-beta - genetics ; Receptor, Interferon alpha-beta - metabolism ; Statistics ; Tumors</subject><ispartof>Genes and immunity, 2011-12, Vol.12 (8), p.653-662</ispartof><rights>The Author(s) 2011</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-9cee82fb2f8b4111a9f49d1f6a3330e73663bf30d5ffcc4ddf5ef7b9e414f2d43</citedby><cites>FETCH-LOGICAL-c526t-9cee82fb2f8b4111a9f49d1f6a3330e73663bf30d5ffcc4ddf5ef7b9e414f2d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/gene.2011.43$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/gene.2011.43$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21716316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ågesen, T H</creatorcontrib><creatorcontrib>Berg, M</creatorcontrib><creatorcontrib>Clancy, T</creatorcontrib><creatorcontrib>Thiis-Evensen, E</creatorcontrib><creatorcontrib>Cekaite, L</creatorcontrib><creatorcontrib>Lind, G E</creatorcontrib><creatorcontrib>Nesland, J M</creatorcontrib><creatorcontrib>Bakka, A</creatorcontrib><creatorcontrib>Mala, T</creatorcontrib><creatorcontrib>Hauss, H J</creatorcontrib><creatorcontrib>Fetveit, T</creatorcontrib><creatorcontrib>Vatn, M H</creatorcontrib><creatorcontrib>Hovig, E</creatorcontrib><creatorcontrib>Nesbakken, A</creatorcontrib><creatorcontrib>Lothe, R A</creatorcontrib><creatorcontrib>Skotheim, R I</creatorcontrib><title>CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer</title><title>Genes and immunity</title><addtitle>Genes Immun</addtitle><addtitle>Genes Immun</addtitle><description>Colorectal cancer (CRC) incidence increases with age, and early onset of the disease is an indication of genetic predisposition, estimated to cause up to 30% of all cases. To identify genes associated with early-onset CRC, we investigated gene expression levels within a series of young patients with CRCs who are not known to carry any hereditary syndromes (
n
=24; mean 43 years at diagnosis), and compared this with a series of CRCs from patients diagnosed at an older age (
n
=17; mean 79 years). Two individual genes were found to be differentially expressed between the two groups, with statistical significance;
CLC
was higher and
IFNAR1
was less expressed in early-onset CRCs. Furthermore, genes located at chromosome band 19q13 were found to be enriched significantly among the genes with higher expression in the early-onset samples, including
CLC
. An elevated immune content within the early-onset group was observed from the differentially expressed genes. By application of outlier statistics,
H3F3A
was identified as a top candidate gene for a subset of the early-onset CRCs. In conclusion,
CLC
and
IFNAR1
were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC.</description><subject>631/208/199</subject><subject>631/208/727/2000</subject><subject>692/699/67/1504/1885</subject><subject>Adult</subject><subject>Age</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cluster Analysis</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - immunology</subject><subject>Disease prevention</subject><subject>Gastrointestinal surgery</subject><subject>Gene Expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic aspects</subject><subject>Geriatrics</subject><subject>Glycoproteins - genetics</subject><subject>Glycoproteins - metabolism</subject><subject>Health risk assessment</subject><subject>Hospitals</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunology</subject><subject>Informatics</subject><subject>Interferon</subject><subject>Lysophospholipase - genetics</subject><subject>Lysophospholipase - metabolism</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Polymerase chain reaction</subject><subject>Receptor, Interferon alpha-beta - genetics</subject><subject>Receptor, Interferon alpha-beta - metabolism</subject><subject>Statistics</subject><subject>Tumors</subject><issn>1466-4879</issn><issn>1476-5470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0sGL1DAUBvAiiruu3jxL0IMIdkyaNGmPw-DqwKCw6jmk6UvJkqZjkuLO2X_cdGdVRhYkh4b0933w4BXFc4JXBNPm3QAeVhUmZMXog-KcMMHLmgn8cLlzXrJGtGfFkxivMSac8PZxcVYRQTgl_Lz4udltkPI92l5-Wl8RpAKg3hoDAXyyyrkDgpt9gBihv3UKDW7qlEN2HGdv0wFFPeWQjTkXk_U6oQ7SDwCPQAV3KG9jTiUoJx8hIT25HNApd2jlNYSnxSOjXIRnd9-L4tvl-6-bj-Xu84ftZr0rdV3xVLYaoKlMV5mmY4QQ1RrW9sRwRSnFICjntDMU97UxWrO-NzUY0bXACDNVz-hF8frYuw_T9xlikqONGpxTHqY5ypY3RFCM8f8lbjCp6kZk-fIfeT3NwecxMhK4Frhd6l4d0aAcSOvNlILSS6VcV4Ix3Iq6ymp1j8qnh9HqyYOx-f0k8OYkkE2CmzSoOUa5_XJ1at8erQ5TjAGM3Ac7qnCQBMtlj-SyR3LZI8lo5i_uxpq7Efo_-PfiZFAeQcy__ADh79z3Fv4C2BbQtw</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Ågesen, T H</creator><creator>Berg, M</creator><creator>Clancy, T</creator><creator>Thiis-Evensen, E</creator><creator>Cekaite, L</creator><creator>Lind, G E</creator><creator>Nesland, J M</creator><creator>Bakka, A</creator><creator>Mala, T</creator><creator>Hauss, H J</creator><creator>Fetveit, T</creator><creator>Vatn, M H</creator><creator>Hovig, E</creator><creator>Nesbakken, A</creator><creator>Lothe, R A</creator><creator>Skotheim, R I</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer</title><author>Ågesen, T H ; Berg, M ; Clancy, T ; Thiis-Evensen, E ; Cekaite, L ; Lind, G E ; Nesland, J M ; Bakka, A ; Mala, T ; Hauss, H J ; Fetveit, T ; Vatn, M H ; Hovig, E ; Nesbakken, A ; Lothe, R A ; Skotheim, R I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-9cee82fb2f8b4111a9f49d1f6a3330e73663bf30d5ffcc4ddf5ef7b9e414f2d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/208/199</topic><topic>631/208/727/2000</topic><topic>692/699/67/1504/1885</topic><topic>Adult</topic><topic>Age</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cluster Analysis</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - 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metabolism</topic><topic>Statistics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ågesen, T H</creatorcontrib><creatorcontrib>Berg, M</creatorcontrib><creatorcontrib>Clancy, T</creatorcontrib><creatorcontrib>Thiis-Evensen, E</creatorcontrib><creatorcontrib>Cekaite, L</creatorcontrib><creatorcontrib>Lind, G E</creatorcontrib><creatorcontrib>Nesland, J M</creatorcontrib><creatorcontrib>Bakka, A</creatorcontrib><creatorcontrib>Mala, T</creatorcontrib><creatorcontrib>Hauss, H J</creatorcontrib><creatorcontrib>Fetveit, T</creatorcontrib><creatorcontrib>Vatn, M H</creatorcontrib><creatorcontrib>Hovig, E</creatorcontrib><creatorcontrib>Nesbakken, A</creatorcontrib><creatorcontrib>Lothe, R A</creatorcontrib><creatorcontrib>Skotheim, R I</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genes and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ågesen, T H</au><au>Berg, M</au><au>Clancy, T</au><au>Thiis-Evensen, E</au><au>Cekaite, L</au><au>Lind, G E</au><au>Nesland, J M</au><au>Bakka, A</au><au>Mala, T</au><au>Hauss, H J</au><au>Fetveit, T</au><au>Vatn, M H</au><au>Hovig, E</au><au>Nesbakken, A</au><au>Lothe, R A</au><au>Skotheim, R I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer</atitle><jtitle>Genes and immunity</jtitle><stitle>Genes Immun</stitle><addtitle>Genes Immun</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>12</volume><issue>8</issue><spage>653</spage><epage>662</epage><pages>653-662</pages><issn>1466-4879</issn><eissn>1476-5470</eissn><abstract>Colorectal cancer (CRC) incidence increases with age, and early onset of the disease is an indication of genetic predisposition, estimated to cause up to 30% of all cases. To identify genes associated with early-onset CRC, we investigated gene expression levels within a series of young patients with CRCs who are not known to carry any hereditary syndromes (
n
=24; mean 43 years at diagnosis), and compared this with a series of CRCs from patients diagnosed at an older age (
n
=17; mean 79 years). Two individual genes were found to be differentially expressed between the two groups, with statistical significance;
CLC
was higher and
IFNAR1
was less expressed in early-onset CRCs. Furthermore, genes located at chromosome band 19q13 were found to be enriched significantly among the genes with higher expression in the early-onset samples, including
CLC
. An elevated immune content within the early-onset group was observed from the differentially expressed genes. By application of outlier statistics,
H3F3A
was identified as a top candidate gene for a subset of the early-onset CRCs. In conclusion,
CLC
and
IFNAR1
were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21716316</pmid><doi>10.1038/gene.2011.43</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1466-4879 |
| ispartof | Genes and immunity, 2011-12, Vol.12 (8), p.653-662 |
| issn | 1466-4879 1476-5470 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_968173000 |
| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 631/208/199 631/208/727/2000 692/699/67/1504/1885 Adult Age Age of Onset Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research Cluster Analysis Colorectal cancer Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Disease prevention Gastrointestinal surgery Gene Expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic aspects Geriatrics Glycoproteins - genetics Glycoproteins - metabolism Health risk assessment Hospitals Human Genetics Humans Immunity Immunology Informatics Interferon Lysophospholipase - genetics Lysophospholipase - metabolism Medical research Middle Aged Neoplasm Staging original-article Physiological aspects Polymerase chain reaction Receptor, Interferon alpha-beta - genetics Receptor, Interferon alpha-beta - metabolism Statistics Tumors |
| title | CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer |
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