Association of Toll-like receptor 10 and susceptibility to Crohn's disease independent of NOD2

Impaired innate inflammatory response has a key role in the Crohn's disease (CD) pathogenesis. The aim of this study was to investigate the possible role of the TLR10–TLR1–TLR6 gene cluster in CD susceptibility. A total of 508 CD patients (284, cohort 1 and 224, cohort 2) and 576 controls were...

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Veröffentlicht in:	Genes and immunity 2011-12, Vol.12 (8), p.635-642
Hauptverfasser:	Abad, C, González-Escribano, M F, Diaz-Gallo, L M, Lucena-Soto, J M, Márquez, J L, Leo, E, Crivell, C, Gómez-García, M, Martín, J, Núñez-Roldán, A, García-Lozano, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/727/2000 631/250/249/2510/257/1402 692/420/2780/262/2106/2108 Adolescent Adult Alleles Bacteria Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Child Confidence intervals Crohn Disease - genetics Crohn's disease Dendritic cells Entropy Female Gene Expression Gene Frequency Genes Genetic aspects Genetic Predisposition to Disease Genotyping Gram-positive bacteria Haplotypes Human Genetics Humans Immunoglobulins Immunology Inflammation Inflammatory bowel diseases Male Messenger RNA Middle Aged Models, Genetic mRNA Mutation NOD2 protein Nod2 Signaling Adaptor Protein - genetics Oligomerization original-article Pathogenesis Pathogens Pattern recognition Phenotype Physiological aspects Polymorphism, Single Nucleotide Single-nucleotide polymorphism Susceptibility TLR1 protein Toll-Like Receptor 1 - genetics Toll-Like Receptor 10 - genetics Toll-Like Receptor 6 - genetics Toll-like receptors Young Adult
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