Molecular characterisation of KIR2DS2005, a fusion gene associated with a shortened KIR haplotype

KIR2DS2 is an activating homologue of KIR2DL2, an inhibitory killer-cell immunoglobulin-like receptor (KIR) that surveys expression of major histocompatibility complex-C allotypes bearing a C1 epitope. We have studied here its allele KIR2DS2*005 , which shows a hybrid structure—it is identical to ot...

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Veröffentlicht in:	Genes and immunity 2011-10, Vol.12 (7), p.544-551
Hauptverfasser:	Ordóñez, D, Gómez-Lozano, N, Rosales, L, Vilches, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/726/649 631/208/728 631/337/149 Alleles Allotypes Base Sequence Biomedical and Life Sciences Biomedicine Cancer Research Epitopes European Continental Ancestry Group - genetics Evolution Female Fusion protein Gene Expression Gene Expression Regulation Gene Fusion Gene Order Genes Genetic aspects Haplotypes Human Genetics Humans Immunoglobulins Immunology Introns Killer cell immunoglobulin-like receptors Lymphocytes Lymphocytes T Major histocompatibility complex Molecular Sequence Data Monoclonal antibodies Mutation original-article Physiological aspects Polymerase chain reaction Polymorphism Population studies Potassium channels (inwardly-rectifying) Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, KIR - genetics Receptors, KIR - metabolism Recombination Sequence Alignment Surveys
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