p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies

The p53 tumor suppressor protein has a key role in the induction of apoptosis of chronic lymphocytic leukemia (CLL) cells. Abnormalities within the p53 pathway identify a subset of patients with a poor prognosis. This review describes recent advances in understanding the mechanisms that regulate p53...

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Veröffentlicht in:	Leukemia 2011-09, Vol.25 (9), p.1400-1407
Hauptverfasser:	Wickremasinghe, R G, Prentice, A G, Steele, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/1244 631/80/82/23 631/80/86 692/699/67/1990/283/1895 Abnormalities Animals Anticancer properties Antineoplastic Agents - therapeutic use Apoptosis Biological and medical sciences Cancer Cancer Research Care and treatment Cell cycle Cellular signal transduction Chemical compounds Chronic lymphocytic leukemia Critical Care Medicine Cytotoxic agents Cytotoxicity Development and progression DNA damage DNA methylation Genes Genetic aspects Hematologic and hematopoietic diseases Hematology Humans Intensive Internal Medicine Kinases Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Localization Lymphatic leukemia Medical sciences Medicine Medicine & Public Health Negative feedback Oncology p53 Protein Pharmacology Phosphorylation Physiological aspects Proteins Receptors, Notch - genetics Receptors, Notch - metabolism review RNA polymerase Signal transduction Signal Transduction - drug effects Signaling Transcription activation Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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