Cutting edge: the role of IFN-α receptor and MyD88 signaling in induction of IL-15 expression in vivo

IL-15 plays a multifaceted role in immune homeostasis, but the unreliability of IL-15 detection has stymied exploration of IL-15 regulation in vivo. To visualize IL-15 expression, we created a transgenic mouse expressing emerald-GFP (EmGFP) under IL-15 promoter control. EmGFP/IL-15 was prevalent in...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-03, Vol.188 (6), p.2483-2487
Hauptverfasser:	Colpitts, Sara L, Stoklasek, Thomas A, Plumlee, Courtney R, Obar, Joshua J, Guo, Caiying, Lefrançois, Leo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Separation Dendritic Cells - immunology Dendritic Cells - metabolism Flow Cytometry Interleukin-15 - biosynthesis Interleukin-15 - immunology Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Confocal Myeloid Differentiation Factor 88 - immunology Myeloid Differentiation Factor 88 - metabolism Receptor, Interferon alpha-beta - immunology Receptor, Interferon alpha-beta - metabolism Signal Transduction - immunology Vesicular Stomatitis - immunology Vesicular stomatitis virus
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