The oncolytic adenovirus Ad Delta enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models

Pancreatic adenocarcinomas are aggressive and frequently develop resistance to all current therapies. Replication-selective adenoviruses can overcome resistance to chemotherapeutics through their sensitizing effects on drug-induced cell killing. We previously found that adenovirus deleted in the ant...

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Veröffentlicht in:	Gene therapy 2011-12, Vol.18 (12), p.1157-1165
Hauptverfasser:	Cherubini, G, Kallin, C, Mozetic, A, Hammaren-Busch, K, Mueller, H, Lemoine, N R, Hallden, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenovirus Cisplatin Cytotoxicity Epithelial cells gemcitabine Gene therapy Irinotecan Oncolysis Pancreatic cancer Replication Toxicity Tumors Xenografts
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