Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer

Three series of natural product asperphenamate derivatives with improved aqueous solubility were designed and synthesized. The in vitro anticancer activities of all derivatives were investigated. IM23b displayed most potent growth inhibitory activity against MCF-7 cells. The mechanism of cell death...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-03, Vol.22 (6), p.2216-2220
Hauptverfasser:	Yuan, Lei, Li, Yanchun, Zou, Chunyang, Wang, Chao, Gao, Jian, Miao, Caixia, Ma, Enlong, Sun, Tiemin
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology apoptosis Aqueous solubility Asperphenamate Autophagy Autophagy - drug effects Biological and medical sciences breast neoplasms cell cycle Cell Line, Tumor Cell Survival - drug effects cisplatin Cisplatin - pharmacology Drug Design Drug Screening Assays, Antitumor Female Humans Inducer Medical sciences Pharmacology. Drug treatments Phenylalanine - analogs & derivatives Phenylalanine - chemical synthesis Phenylalanine - pharmacology Solubility Structure-Activity Relationship Structure–activity relationships
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