Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer's disease

Patients with Alzheimer's disease (AD) suffer from impaired memory and emotional disturbances, the pathogenesis of which is not entirely clear. In APP/PS1 transgenic mice, a model of AD in which amyloid β (Aβ) accumulates in the brain, we have examined neurons in the lateral nucleus of the amyg...

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Veröffentlicht in:	The Journal of pathology 2009-09, Vol.219 (1), p.41-51
Hauptverfasser:	Knafo, Shira, Venero, Cesar, Merino-Serrais, Paula, Fernaud-Espinosa, Isabel, Gonzalez-Soriano, Juncal, Ferrer, Isidro, Santpere, Gabriel, DeFelipe, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alzheimer Disease - pathology Alzheimer Disease - psychology Alzheimer's disease Amygdala - ultrastructure amyloid Animals APP Biological and medical sciences cognition Conditioning, Classical confocal microscopy Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases dementia dendritic spines Dendritic Spines - ultrastructure Fear Investigative techniques, diagnostic techniques (general aspects) learning Male Medical sciences Mice Mice, Transgenic Microscopy, Confocal Models, Animal morphology Neurology Neuronal Plasticity Organic mental disorders. Neuropsychology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Plaque, Amyloid - ultrastructure plaques PS1 Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry unbiased stereology
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