Intensified chemotherapy inspired by a pediatric regimen combined with allogeneic transplantation in adult patients with acute lymphoblastic leukemia up to the age of 40

Event-free survival (EFS) at 5 years in pediatric acute lymphoblastic leukemia (ALL) is >80%. Outcome in adult ALL is still unsatisfactory, which is due to less cumulative dosing of chemotherapy and less strict adherence to timing of successive cycles. In the present phase II trial, we evaluated...

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Veröffentlicht in:	Leukemia 2011-11, Vol.25 (11), p.1697-1703
Hauptverfasser:	Rijneveld, A W, van der Holt, B, Daenen, S M G J, Biemond, B J, de Weerdt, O, Muus, P, Maertens, J, Mattijssen, V, Demuynck, H, Legdeur, M C J C, Wijermans, P W, Wittebol, S, Spoelstra, F M, Dekker, A W, Ossenkoppele, G J, Willemze, R, Cornelissen, J J
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/67/1059/99 692/699/67/1990/283/2125 692/700/565/545/576/1955 Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent Adult Adults Age Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Asparaginase Biological and medical sciences Bone marrow Bone Marrow Transplantation Cancer Cancer Research Care and treatment Chemotherapy Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Critical Care Medicine Demographic aspects Dosage Drug dosages Feasibility Feasibility Studies Female Hematologic and hematopoietic diseases Hematology Humans Intensive Internal Medicine Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Male Medical sciences Medicine Medicine & Public Health Methotrexate Middle Aged Morphology Oncology original-article Patient outcomes Patients Pediatrics Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery Remission Remission (Medicine) Remission Induction Risk Risk groups Side effects Stem cell transplantation Stem cells Steroid hormones Survival Transplantation Young Adult
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