Structure–activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification

The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respirat...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-03, Vol.22 (6), p.2338-2342
Hauptverfasser:	Sun, Xicheng, Qiu, Jian, Strong, Sarah A., Green, Louis S., Wasley, Jan W.F., Blonder, Joan P., Colagiovanni, Dorothy B., Stout, Adam M., Mutka, Sarah C., Richards, Jane P., Rosenthal, Gary J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease alcohol dehydrogenase Aldehyde Oxidoreductases - antagonists & inhibitors Aldehyde Oxidoreductases - metabolism Animals Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - chemical synthesis Anti-Asthmatic Agents - therapeutic use Asthma Asthma - chemically induced Asthma - drug therapy Asthma - enzymology Benzamides - administration & dosage Benzamides - chemical synthesis Benzamides - therapeutic use Biological and medical sciences Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - therapeutic use gastrointestinal system GSNO GSNOR GSNOR inhibitor Humans Male Medical sciences metabolism Mice N6022 Nitric oxide Nitrosothiols Ovalbumin pathogenesis Pharmacology. Drug treatments Pyrroles - administration & dosage Pyrroles - chemical synthesis Pyrroles - therapeutic use S-Nitrosoglutathione - metabolism S-Nitrosothiols - metabolism Structure-Activity Relationship structure-activity relationships
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