Ibuprofen worsens Streptococcus pyogenes soft tissue infections in mice
Background Group A streptococcus (GAS) is a common cause of soft tissue infection. Nonsteroidal anti-inflammatory drugs have been reported to worsen GAS soft tissue infections. Methods A mouse model of GAS soft tissue infection was developed. The extent of cutaneous lesions, tissue damage, release o...
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| Veröffentlicht in: | Journal of microbiology, immunology and infection immunology and infection, 2011-12, Vol.44 (6), p.418-423 |
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| creator | Weng, Tzu-Chieh Chen, Chi-Chung Toh, Han-Siong Tang, Hung-Jen |
| description | Background Group A streptococcus (GAS) is a common cause of soft tissue infection. Nonsteroidal anti-inflammatory drugs have been reported to worsen GAS soft tissue infections. Methods A mouse model of GAS soft tissue infection was developed. The extent of cutaneous lesions, tissue damage, release of inflammatory cytokines, and survival rates were compared between mice with and without ibuprofen administration after GAS soft tissue infection. Results All twelve mice without ibuprofen administration survived for at least 10 days. In contrast, mortality rate of 14 mice with ibuprofen therapy was 72.5%. Ibuprofen-treated mice exhibited more evident macrophage infiltration and tissue damage in the GAS-infected soft tissues. In GAS-infected mice, tissue levels of interleukin 6 and tumor necrosis factor alpha were significantly higher in ibuprofen-treated mice than those in the control group. Conclusions The results supported the concept that ibuprofen use in GAS soft tissue infections might induce the development of severe necrotizing infections and increase mortality rate. |
| doi_str_mv | 10.1016/j.jmii.2011.04.012 |
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Nonsteroidal anti-inflammatory drugs have been reported to worsen GAS soft tissue infections. Methods A mouse model of GAS soft tissue infection was developed. The extent of cutaneous lesions, tissue damage, release of inflammatory cytokines, and survival rates were compared between mice with and without ibuprofen administration after GAS soft tissue infection. Results All twelve mice without ibuprofen administration survived for at least 10 days. In contrast, mortality rate of 14 mice with ibuprofen therapy was 72.5%. Ibuprofen-treated mice exhibited more evident macrophage infiltration and tissue damage in the GAS-infected soft tissues. In GAS-infected mice, tissue levels of interleukin 6 and tumor necrosis factor alpha were significantly higher in ibuprofen-treated mice than those in the control group. Conclusions The results supported the concept that ibuprofen use in GAS soft tissue infections might induce the development of severe necrotizing infections and increase mortality rate.</description><identifier>ISSN: 1684-1182</identifier><identifier>EISSN: 1995-9133</identifier><identifier>DOI: 10.1016/j.jmii.2011.04.012</identifier><identifier>PMID: 21697021</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animal model ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - toxicity ; Disease Models, Animal ; Fasciitis, Necrotizing - chemically induced ; Fasciitis, Necrotizing - microbiology ; Female ; Histocytochemistry ; Ibuprofen - toxicity ; Infectious Disease ; Interleukin-6 - blood ; Interleukin-6 - metabolism ; Medical Education ; Mice ; Mice, Inbred BALB C ; Nonsteroidal anti-inflammatory drugs ; Soft tissue infection ; Soft Tissue Infections - drug therapy ; Soft Tissue Infections - metabolism ; Soft Tissue Infections - microbiology ; Soft Tissue Infections - pathology ; Streptococcal infection ; Streptococcal Infections - drug therapy ; Streptococcal Infections - metabolism ; Streptococcal Infections - microbiology ; Streptococcal Infections - pathology ; Streptococcus pyogenes ; Streptococcus pyogenes - drug effects ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Journal of microbiology, immunology and infection, 2011-12, Vol.44 (6), p.418-423</ispartof><rights>2011</rights><rights>Copyright © 2011. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-6243333b9e5e7f7085adde0aad28684c460493b13b3326e865d650d53a8123233</citedby><cites>FETCH-LOGICAL-c442t-6243333b9e5e7f7085adde0aad28684c460493b13b3326e865d650d53a8123233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jmii.2011.04.012$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21697021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weng, Tzu-Chieh</creatorcontrib><creatorcontrib>Chen, Chi-Chung</creatorcontrib><creatorcontrib>Toh, Han-Siong</creatorcontrib><creatorcontrib>Tang, Hung-Jen</creatorcontrib><title>Ibuprofen worsens Streptococcus pyogenes soft tissue infections in mice</title><title>Journal of microbiology, immunology and infection</title><addtitle>J Microbiol Immunol Infect</addtitle><description>Background Group A streptococcus (GAS) is a common cause of soft tissue infection. Nonsteroidal anti-inflammatory drugs have been reported to worsen GAS soft tissue infections. Methods A mouse model of GAS soft tissue infection was developed. The extent of cutaneous lesions, tissue damage, release of inflammatory cytokines, and survival rates were compared between mice with and without ibuprofen administration after GAS soft tissue infection. Results All twelve mice without ibuprofen administration survived for at least 10 days. In contrast, mortality rate of 14 mice with ibuprofen therapy was 72.5%. Ibuprofen-treated mice exhibited more evident macrophage infiltration and tissue damage in the GAS-infected soft tissues. In GAS-infected mice, tissue levels of interleukin 6 and tumor necrosis factor alpha were significantly higher in ibuprofen-treated mice than those in the control group. Conclusions The results supported the concept that ibuprofen use in GAS soft tissue infections might induce the development of severe necrotizing infections and increase mortality rate.</description><subject>Animal model</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - toxicity</subject><subject>Disease Models, Animal</subject><subject>Fasciitis, Necrotizing - chemically induced</subject><subject>Fasciitis, Necrotizing - microbiology</subject><subject>Female</subject><subject>Histocytochemistry</subject><subject>Ibuprofen - toxicity</subject><subject>Infectious Disease</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - metabolism</subject><subject>Medical Education</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Soft tissue infection</subject><subject>Soft Tissue Infections - drug therapy</subject><subject>Soft Tissue Infections - metabolism</subject><subject>Soft Tissue Infections - microbiology</subject><subject>Soft Tissue Infections - pathology</subject><subject>Streptococcal infection</subject><subject>Streptococcal Infections - drug therapy</subject><subject>Streptococcal Infections - metabolism</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcal Infections - pathology</subject><subject>Streptococcus pyogenes</subject><subject>Streptococcus pyogenes - drug effects</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>1684-1182</issn><issn>1995-9133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1TAQRS0EakvpD7BA2bFKmLEdv0RCSKiCtlKlLgprK3EmyCGJH56k1ft7HL3CggX1xl6cezU-I8RbhAIBzYehGCbvCwmIBegCUL4QZ1jXZV6jUi_T21Q6R6zkqXjNPABoJUtzIk4lmnoHEs_E1U277mPoac4eQ2SaObtfIu2X4IJzK2f7Q_hBM3HGoV-yxTOvlPm5J7f4kGg_Z5N39Ea86puR6eLpPhffv375dnmd395d3Vx-vs2d1nLJjdQqnbamknb9Dqqy6TqCpulklYZ12oCuVYuqVUoaqkzZmRK6UjUVSiWVOhfvj71p6F8r8WInz47GsZkprGxrU6VfK43Pk1DtVK1KmUh5JF0MzJF6u49-auLBItjNtB3sZtpupi1om0yn0Lun-rWdqPsb-aM2AR-PACUdD56iZedpdtT5mOTZLvj_93_6J-5GP3vXjD_pQDyENc5JtEXL0oK933a9rRoRIG1fqt9xz6L3</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Weng, Tzu-Chieh</creator><creator>Chen, Chi-Chung</creator><creator>Toh, Han-Siong</creator><creator>Tang, Hung-Jen</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20111201</creationdate><title>Ibuprofen worsens Streptococcus pyogenes soft tissue infections in mice</title><author>Weng, Tzu-Chieh ; Chen, Chi-Chung ; Toh, Han-Siong ; Tang, Hung-Jen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-6243333b9e5e7f7085adde0aad28684c460493b13b3326e865d650d53a8123233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animal model</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - toxicity</topic><topic>Disease Models, Animal</topic><topic>Fasciitis, Necrotizing - chemically induced</topic><topic>Fasciitis, Necrotizing - microbiology</topic><topic>Female</topic><topic>Histocytochemistry</topic><topic>Ibuprofen - toxicity</topic><topic>Infectious Disease</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - metabolism</topic><topic>Medical Education</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Soft tissue infection</topic><topic>Soft Tissue Infections - drug therapy</topic><topic>Soft Tissue Infections - metabolism</topic><topic>Soft Tissue Infections - microbiology</topic><topic>Soft Tissue Infections - pathology</topic><topic>Streptococcal infection</topic><topic>Streptococcal Infections - drug therapy</topic><topic>Streptococcal Infections - metabolism</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcal Infections - pathology</topic><topic>Streptococcus pyogenes</topic><topic>Streptococcus pyogenes - drug effects</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weng, Tzu-Chieh</creatorcontrib><creatorcontrib>Chen, Chi-Chung</creatorcontrib><creatorcontrib>Toh, Han-Siong</creatorcontrib><creatorcontrib>Tang, Hung-Jen</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of microbiology, immunology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weng, Tzu-Chieh</au><au>Chen, Chi-Chung</au><au>Toh, Han-Siong</au><au>Tang, Hung-Jen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ibuprofen worsens Streptococcus pyogenes soft tissue infections in mice</atitle><jtitle>Journal of microbiology, immunology and infection</jtitle><addtitle>J Microbiol Immunol Infect</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>44</volume><issue>6</issue><spage>418</spage><epage>423</epage><pages>418-423</pages><issn>1684-1182</issn><eissn>1995-9133</eissn><abstract>Background Group A streptococcus (GAS) is a common cause of soft tissue infection. Nonsteroidal anti-inflammatory drugs have been reported to worsen GAS soft tissue infections. Methods A mouse model of GAS soft tissue infection was developed. The extent of cutaneous lesions, tissue damage, release of inflammatory cytokines, and survival rates were compared between mice with and without ibuprofen administration after GAS soft tissue infection. Results All twelve mice without ibuprofen administration survived for at least 10 days. In contrast, mortality rate of 14 mice with ibuprofen therapy was 72.5%. Ibuprofen-treated mice exhibited more evident macrophage infiltration and tissue damage in the GAS-infected soft tissues. In GAS-infected mice, tissue levels of interleukin 6 and tumor necrosis factor alpha were significantly higher in ibuprofen-treated mice than those in the control group. Conclusions The results supported the concept that ibuprofen use in GAS soft tissue infections might induce the development of severe necrotizing infections and increase mortality rate.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>21697021</pmid><doi>10.1016/j.jmii.2011.04.012</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal model Animals Anti-Inflammatory Agents, Non-Steroidal - toxicity Disease Models, Animal Fasciitis, Necrotizing - chemically induced Fasciitis, Necrotizing - microbiology Female Histocytochemistry Ibuprofen - toxicity Infectious Disease Interleukin-6 - blood Interleukin-6 - metabolism Medical Education Mice Mice, Inbred BALB C Nonsteroidal anti-inflammatory drugs Soft tissue infection Soft Tissue Infections - drug therapy Soft Tissue Infections - metabolism Soft Tissue Infections - microbiology Soft Tissue Infections - pathology Streptococcal infection Streptococcal Infections - drug therapy Streptococcal Infections - metabolism Streptococcal Infections - microbiology Streptococcal Infections - pathology Streptococcus pyogenes Streptococcus pyogenes - drug effects Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - metabolism |
| title | Ibuprofen worsens Streptococcus pyogenes soft tissue infections in mice |
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