Molecular analysis of relapses or reinfections of Clostridium difficile-associated diarrhea

Recurrence is a major complication of Clostridium difficile-associated diarrhea and occurs in 15 to 20% of patients after discontinuation of therapy. Strains from 53 patients with Clostridium difficile recurrences were fingerprinted by PCR ribotyping. Reinfection with a different strain occurred in...

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Veröffentlicht in:	The New microbiologica 2011-10, Vol.34 (4), p.399-402
Hauptverfasser:	Sisto, Francesca, Scaltrito, Maria Maddalena, Zago, Miriam, Bonomi, Arianna, Coccè, Valentina, Frugoni, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Clostridium Clostridium difficile Clostridium difficile - genetics Clostridium difficile - isolation & purification Diarrhea - diagnosis Diarrhea - microbiology DNA Fingerprinting - methods Enterocolitis, Pseudomembranous - diagnosis Enterocolitis, Pseudomembranous - microbiology Humans Polymerase Chain Reaction - methods Random Amplified Polymorphic DNA Technique - methods Recurrence
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creator	Sisto, Francesca Scaltrito, Maria Maddalena Zago, Miriam Bonomi, Arianna Coccè, Valentina Frugoni, Sergio
description	Recurrence is a major complication of Clostridium difficile-associated diarrhea and occurs in 15 to 20% of patients after discontinuation of therapy. Strains from 53 patients with Clostridium difficile recurrences were fingerprinted by PCR ribotyping. Reinfection with a different strain occurred in 15 out of 53 patients (28,3%), while 38 patients relapsed. These data suggest the need to perform molecular typing for implementation of infection control procedures and for a more appropriate therapeutic strategy.
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subjects	Clostridium Clostridium difficile Clostridium difficile - genetics Clostridium difficile - isolation & purification Diarrhea - diagnosis Diarrhea - microbiology DNA Fingerprinting - methods Enterocolitis, Pseudomembranous - diagnosis Enterocolitis, Pseudomembranous - microbiology Humans Polymerase Chain Reaction - methods Random Amplified Polymorphic DNA Technique - methods Recurrence
title	Molecular analysis of relapses or reinfections of Clostridium difficile-associated diarrhea
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