VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells

VEGF-, phosphoinositide 3-kinase (PI3K)- and protein kinase C (PKC)-regulated signaling in cardiac and vascular differentiation was investigated in mouse ES cells and in ES cell-derived Flk-1⁺ cardiovascular progenitor cells. Inhibition of PI3K by wortmannin and LY294002, disruption of PI3K catalyti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cell science 2011-06, Vol.124 (Pt 11), p.1819-1830
Hauptverfasser:	Bekhite, Mohamed M, Finkensieper, Andreas, Binas, Stephanie, Müller, Jörg, Wetzker, Reinhard, Figulla, Hans-Reiner, Sauer, Heinrich, Wartenberg, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalytic Domain Cell Differentiation Cell Line Chromones - pharmacology Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors Class Ia Phosphatidylinositol 3-Kinase - genetics Class Ia Phosphatidylinositol 3-Kinase - metabolism Embryoid Bodies - cytology Embryoid Bodies - drug effects Enzyme Activation Mice Morpholines - pharmacology Muscle Development Myocardium - cytology Myocardium - metabolism Neovascularization, Physiologic Protein Kinase C - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA Interference Signal Transduction Vascular Endothelial Growth Factor A - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!