Selective effect of INGAP-PP upon mouse embryonic stem cell differentiation toward islet cells

We evaluated the effect of islet neogenesis-associated protein pentadecapeptide (INGAP-PP) upon islet β- and non-β cell differentiation from mouse embryonic stem (mES) cells. ES-D3 cell lines were cultured following Lumelsky's protocol with or without INGAP-PP (5 µg/ml) at different stages. Gen...

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Veröffentlicht in:	Regulatory peptides 2009-02, Vol.153 (1), p.43-48
Hauptverfasser:	Francini, Flavio, Del Zotto, Héctor, Massa, María L., Gagliardino, Juan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers - metabolism Cell Differentiation - drug effects Cell Differentiation - physiology Cells, Cultured Differentiation Embryonic stem cells Embryonic Stem Cells - drug effects Embryonic Stem Cells - physiology Fundamental and applied biological sciences. Psychology Humans INGAP-PP Insulin-producing cells Islets of Langerhans - cytology Islets of Langerhans - physiology Mice Pancreatitis-Associated Proteins Peptides - genetics Peptides - metabolism Peptides - pharmacology Proteins - genetics Proteins - metabolism Proteins - pharmacology Vertebrates: endocrinology
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