Resveratrol derivative, trans-3,5,4′-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation

Angiogenesis plays an important role in the development of neoplastic diseases such as cancer. Resveratrol and its derivatives exert antiangiogenic effects, but the mechanisms of their actions remain unclear. The aim of this study was to evaluate the antiangiogenic activity of resveratrol and its de...

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Veröffentlicht in:	Journal of cellular biochemistry 2010-02, Vol.109 (2), p.339-346
Hauptverfasser:	Alex, Deepa, Leong, Emilia Conceição, Zhang, Zai-Jun, Yan, Gloria Tse Ho, Cheng, Shuk-Han, Leong, Chi-Weng, Li, Zhen-Hua, Lam, Kai-Heng, Chan, Shun-Wan, Lee, Simon Ming-Yuen
Format:	Artikel
Sprache:	eng
Schlagworte:	3,5,4′‐trimethoxystilbene 4′-trimethoxystilbene angiogenesis Animals Animals, Genetically Modified Cell Cycle Cell Line, Tumor Cell Proliferation Danio rerio Down-Regulation - drug effects Embryo, Nonmammalian - cytology Embryo, Nonmammalian - physiology Endothelial Cells - cytology Endothelial Cells - drug effects Freshwater Humans HUVEC Neovascularization, Physiologic - drug effects Stilbenes - chemistry Stilbenes - pharmacology Transcription, Genetic - drug effects Umbilical Veins - cytology Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGFR2 zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism
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