Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose
In several countries, including the Netherlands, the use of GHB seems to be rising. GHB is regarded by recreational users as an innocent drug without any side effects. Recently, the number of patients in treatment due to GHB addiction sharply increased. In addition, various studies report incidents...
Gespeichert in:
| Veröffentlicht in: | Neuroscience and biobehavioral reviews 2012-04, Vol.36 (4), p.1217-1227 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1227 |
|---|---|
| container_issue | 4 |
| container_start_page | 1217 |
| container_title | Neuroscience and biobehavioral reviews |
| container_volume | 36 |
| creator | AMSTERDAM, Jan G. C. Van BRUNT, Tibor M MCMASTER, Minni T. B NIESINK, Raymond J. M |
| description | In several countries, including the Netherlands, the use of GHB seems to be rising. GHB is regarded by recreational users as an innocent drug without any side effects. Recently, the number of patients in treatment due to GHB addiction sharply increased. In addition, various studies report incidents following risky GHB use or GHB overdosing. Other sedative drugs, like ketamine and alcohol have been shown to result in unintended neurotoxic harm at the level of memory and cognitive function. As outlined in the present review, GHB and ketamine have a common mode of action, which suggests that GHB may also lead to similar neurotoxicity as ketamine. GHB overdosing, as well as binge drinking (and high ketamine doses), induce profound coma which is probably neurotoxic for the brain especially in the maturing brain of young adults. It is therefore advocated to investigate possible long-term neurotoxic effects in recreational GHB users e.g. by studying the residual effects on cognition and memory. |
| doi_str_mv | 10.1016/j.neubiorev.2012.02.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_968165523</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>968165523</sourcerecordid><originalsourceid>FETCH-LOGICAL-c374t-1b8c93851b065beefe64b399f3fb5b91eeca76f3ce90d1ffc38f070e92cbf4b23</originalsourceid><addsrcrecordid>eNpFkNtKxDAQhoMouh5eQXMj6kXXHNqmudTFEwh6oXdCSNKJZuk2mrRin8v38Jns4qowMDffzD_zIXRAyZQSWp7Opy30xocI71NGKJuSsQhbQxNaCZ6JglXraEJoLjNR8nwLbac0JyNBeLGJthjjORNCTtDTfUjJmwZwE9rnrIO4wOAc2C7h4PDXZ_Yy1DF8DKbvhugt1tbX-Pjq-vwE1z3gLuDxkhi68OGt7was2xqHd4h1SLCLNpxuEuyt-g56vLx4mF1nt3dXN7Oz28xykXcZNZWVvCqoIWVhAByUueFSOu5MYSQFsFqUjluQpKbOWV45IghIZo3LDeM76Ohn72sMbz2kTi18stA0uoXQJyXLipZFwfhIih_SxvHvCE69Rr_QcVCUqKVZNVd_ZtXSrCJjkWXG_iqjNwuo_-Z-VY7A4QrQyerGRd1an_65QjBR5hX_BkgChzQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>968165523</pqid></control><display><type>article</type><title>Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>AMSTERDAM, Jan G. C. Van ; BRUNT, Tibor M ; MCMASTER, Minni T. B ; NIESINK, Raymond J. M</creator><creatorcontrib>AMSTERDAM, Jan G. C. Van ; BRUNT, Tibor M ; MCMASTER, Minni T. B ; NIESINK, Raymond J. M</creatorcontrib><description>In several countries, including the Netherlands, the use of GHB seems to be rising. GHB is regarded by recreational users as an innocent drug without any side effects. Recently, the number of patients in treatment due to GHB addiction sharply increased. In addition, various studies report incidents following risky GHB use or GHB overdosing. Other sedative drugs, like ketamine and alcohol have been shown to result in unintended neurotoxic harm at the level of memory and cognitive function. As outlined in the present review, GHB and ketamine have a common mode of action, which suggests that GHB may also lead to similar neurotoxicity as ketamine. GHB overdosing, as well as binge drinking (and high ketamine doses), induce profound coma which is probably neurotoxic for the brain especially in the maturing brain of young adults. It is therefore advocated to investigate possible long-term neurotoxic effects in recreational GHB users e.g. by studying the residual effects on cognition and memory.</description><identifier>ISSN: 0149-7634</identifier><identifier>EISSN: 1873-7528</identifier><identifier>DOI: 10.1016/j.neubiorev.2012.02.002</identifier><identifier>PMID: 22342779</identifier><language>eng</language><publisher>Kidlington: Elsevier</publisher><subject>Alcoholism - physiopathology ; Alcoholism - psychology ; Anesthetics - toxicity ; Anesthetics, Dissociative - adverse effects ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Central Nervous System Depressants - adverse effects ; Cognition Disorders - chemically induced ; Cognition Disorders - psychology ; Coma - chemically induced ; Coma - physiopathology ; Drug Overdose ; Ethanol - adverse effects ; Fundamental and applied biological sciences. Psychology ; Glutamic Acid - physiology ; Humans ; Ketamine - adverse effects ; Neurotoxicity Syndromes - physiopathology ; Oxidative Stress - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Sodium Oxybate - adverse effects ; Sodium Oxybate - poisoning ; Sodium Oxybate - toxicity ; Street Drugs ; Substance Withdrawal Syndrome - physiopathology ; Substance Withdrawal Syndrome - psychology ; Substance-Related Disorders - physiopathology ; Substance-Related Disorders - psychology ; Succinate-Semialdehyde Dehydrogenase - deficiency</subject><ispartof>Neuroscience and biobehavioral reviews, 2012-04, Vol.36 (4), p.1217-1227</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-1b8c93851b065beefe64b399f3fb5b91eeca76f3ce90d1ffc38f070e92cbf4b23</citedby><cites>FETCH-LOGICAL-c374t-1b8c93851b065beefe64b399f3fb5b91eeca76f3ce90d1ffc38f070e92cbf4b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25727648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22342779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AMSTERDAM, Jan G. C. Van</creatorcontrib><creatorcontrib>BRUNT, Tibor M</creatorcontrib><creatorcontrib>MCMASTER, Minni T. B</creatorcontrib><creatorcontrib>NIESINK, Raymond J. M</creatorcontrib><title>Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose</title><title>Neuroscience and biobehavioral reviews</title><addtitle>Neurosci Biobehav Rev</addtitle><description>In several countries, including the Netherlands, the use of GHB seems to be rising. GHB is regarded by recreational users as an innocent drug without any side effects. Recently, the number of patients in treatment due to GHB addiction sharply increased. In addition, various studies report incidents following risky GHB use or GHB overdosing. Other sedative drugs, like ketamine and alcohol have been shown to result in unintended neurotoxic harm at the level of memory and cognitive function. As outlined in the present review, GHB and ketamine have a common mode of action, which suggests that GHB may also lead to similar neurotoxicity as ketamine. GHB overdosing, as well as binge drinking (and high ketamine doses), induce profound coma which is probably neurotoxic for the brain especially in the maturing brain of young adults. It is therefore advocated to investigate possible long-term neurotoxic effects in recreational GHB users e.g. by studying the residual effects on cognition and memory.</description><subject>Alcoholism - physiopathology</subject><subject>Alcoholism - psychology</subject><subject>Anesthetics - toxicity</subject><subject>Anesthetics, Dissociative - adverse effects</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Depressants - adverse effects</subject><subject>Cognition Disorders - chemically induced</subject><subject>Cognition Disorders - psychology</subject><subject>Coma - chemically induced</subject><subject>Coma - physiopathology</subject><subject>Drug Overdose</subject><subject>Ethanol - adverse effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutamic Acid - physiology</subject><subject>Humans</subject><subject>Ketamine - adverse effects</subject><subject>Neurotoxicity Syndromes - physiopathology</subject><subject>Oxidative Stress - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Sodium Oxybate - adverse effects</subject><subject>Sodium Oxybate - poisoning</subject><subject>Sodium Oxybate - toxicity</subject><subject>Street Drugs</subject><subject>Substance Withdrawal Syndrome - physiopathology</subject><subject>Substance Withdrawal Syndrome - psychology</subject><subject>Substance-Related Disorders - physiopathology</subject><subject>Substance-Related Disorders - psychology</subject><subject>Succinate-Semialdehyde Dehydrogenase - deficiency</subject><issn>0149-7634</issn><issn>1873-7528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNtKxDAQhoMouh5eQXMj6kXXHNqmudTFEwh6oXdCSNKJZuk2mrRin8v38Jns4qowMDffzD_zIXRAyZQSWp7Opy30xocI71NGKJuSsQhbQxNaCZ6JglXraEJoLjNR8nwLbac0JyNBeLGJthjjORNCTtDTfUjJmwZwE9rnrIO4wOAc2C7h4PDXZ_Yy1DF8DKbvhugt1tbX-Pjq-vwE1z3gLuDxkhi68OGt7was2xqHd4h1SLCLNpxuEuyt-g56vLx4mF1nt3dXN7Oz28xykXcZNZWVvCqoIWVhAByUueFSOu5MYSQFsFqUjluQpKbOWV45IghIZo3LDeM76Ohn72sMbz2kTi18stA0uoXQJyXLipZFwfhIih_SxvHvCE69Rr_QcVCUqKVZNVd_ZtXSrCJjkWXG_iqjNwuo_-Z-VY7A4QrQyerGRd1an_65QjBR5hX_BkgChzQ</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>AMSTERDAM, Jan G. C. Van</creator><creator>BRUNT, Tibor M</creator><creator>MCMASTER, Minni T. B</creator><creator>NIESINK, Raymond J. M</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20120401</creationdate><title>Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose</title><author>AMSTERDAM, Jan G. C. Van ; BRUNT, Tibor M ; MCMASTER, Minni T. B ; NIESINK, Raymond J. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-1b8c93851b065beefe64b399f3fb5b91eeca76f3ce90d1ffc38f070e92cbf4b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alcoholism - physiopathology</topic><topic>Alcoholism - psychology</topic><topic>Anesthetics - toxicity</topic><topic>Anesthetics, Dissociative - adverse effects</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Depressants - adverse effects</topic><topic>Cognition Disorders - chemically induced</topic><topic>Cognition Disorders - psychology</topic><topic>Coma - chemically induced</topic><topic>Coma - physiopathology</topic><topic>Drug Overdose</topic><topic>Ethanol - adverse effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutamic Acid - physiology</topic><topic>Humans</topic><topic>Ketamine - adverse effects</topic><topic>Neurotoxicity Syndromes - physiopathology</topic><topic>Oxidative Stress - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Sodium Oxybate - adverse effects</topic><topic>Sodium Oxybate - poisoning</topic><topic>Sodium Oxybate - toxicity</topic><topic>Street Drugs</topic><topic>Substance Withdrawal Syndrome - physiopathology</topic><topic>Substance Withdrawal Syndrome - psychology</topic><topic>Substance-Related Disorders - physiopathology</topic><topic>Substance-Related Disorders - psychology</topic><topic>Succinate-Semialdehyde Dehydrogenase - deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AMSTERDAM, Jan G. C. Van</creatorcontrib><creatorcontrib>BRUNT, Tibor M</creatorcontrib><creatorcontrib>MCMASTER, Minni T. B</creatorcontrib><creatorcontrib>NIESINK, Raymond J. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience and biobehavioral reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AMSTERDAM, Jan G. C. Van</au><au>BRUNT, Tibor M</au><au>MCMASTER, Minni T. B</au><au>NIESINK, Raymond J. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose</atitle><jtitle>Neuroscience and biobehavioral reviews</jtitle><addtitle>Neurosci Biobehav Rev</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>36</volume><issue>4</issue><spage>1217</spage><epage>1227</epage><pages>1217-1227</pages><issn>0149-7634</issn><eissn>1873-7528</eissn><abstract>In several countries, including the Netherlands, the use of GHB seems to be rising. GHB is regarded by recreational users as an innocent drug without any side effects. Recently, the number of patients in treatment due to GHB addiction sharply increased. In addition, various studies report incidents following risky GHB use or GHB overdosing. Other sedative drugs, like ketamine and alcohol have been shown to result in unintended neurotoxic harm at the level of memory and cognitive function. As outlined in the present review, GHB and ketamine have a common mode of action, which suggests that GHB may also lead to similar neurotoxicity as ketamine. GHB overdosing, as well as binge drinking (and high ketamine doses), induce profound coma which is probably neurotoxic for the brain especially in the maturing brain of young adults. It is therefore advocated to investigate possible long-term neurotoxic effects in recreational GHB users e.g. by studying the residual effects on cognition and memory.</abstract><cop>Kidlington</cop><pub>Elsevier</pub><pmid>22342779</pmid><doi>10.1016/j.neubiorev.2012.02.002</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-7634 |
| ispartof | Neuroscience and biobehavioral reviews, 2012-04, Vol.36 (4), p.1217-1227 |
| issn | 0149-7634 1873-7528 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_968165523 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Alcoholism - physiopathology Alcoholism - psychology Anesthetics - toxicity Anesthetics, Dissociative - adverse effects Animals Behavioral psychophysiology Biological and medical sciences Central Nervous System Depressants - adverse effects Cognition Disorders - chemically induced Cognition Disorders - psychology Coma - chemically induced Coma - physiopathology Drug Overdose Ethanol - adverse effects Fundamental and applied biological sciences. Psychology Glutamic Acid - physiology Humans Ketamine - adverse effects Neurotoxicity Syndromes - physiopathology Oxidative Stress - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Sodium Oxybate - adverse effects Sodium Oxybate - poisoning Sodium Oxybate - toxicity Street Drugs Substance Withdrawal Syndrome - physiopathology Substance Withdrawal Syndrome - psychology Substance-Related Disorders - physiopathology Substance-Related Disorders - psychology Succinate-Semialdehyde Dehydrogenase - deficiency |
| title | Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T09%3A28%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Possible%20long-term%20effects%20of%20%CE%B3-hydroxybutyric%20acid%20(GHB)%20due%20to%20neurotoxicity%20and%20overdose&rft.jtitle=Neuroscience%20and%20biobehavioral%20reviews&rft.au=AMSTERDAM,%20Jan%20G.%20C.%20Van&rft.date=2012-04-01&rft.volume=36&rft.issue=4&rft.spage=1217&rft.epage=1227&rft.pages=1217-1227&rft.issn=0149-7634&rft.eissn=1873-7528&rft_id=info:doi/10.1016/j.neubiorev.2012.02.002&rft_dat=%3Cproquest_cross%3E968165523%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=968165523&rft_id=info:pmid/22342779&rfr_iscdi=true |